| Project/Area Number |
60570342
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
SHIMURA Sanae Assistant of Professor, First Department of Internal Medicine, Tohoku, 医学部, 助手 (20154312)
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| Co-Investigator(Kenkyū-buntansha) |
OKAYAMA Hiroshi Assistant of Professor, First Department of Internal Medicine, School of Medicin, 医学部, 助手 (10160730)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Airway mucus secretion / Submucosal gland / Mucus squeezing / Secretory cell secreton / Substance P / Autonomic innervation / <Na^+> - <K^+> ATPase |
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| Research Abstract |
Using newly developed an in vitro model "isolated submucosal gland", we have obtained the following results.
1. Airway mucus secretion consists of mucus squeezing by myoepithelial cell contraction and secretory cell secretion. The former action is related to the short-time response (a few minutes) and the lather to the long-term responses.
2. The extra-and/or "intracellular <Ca^(2+)> plays an important role in mucus secretion.
3. Mucus squeezing is mediated mainly by cholinergic nerves, whereas secretory cell secretion is mediated by cholinergic, adrenergic and noncholinergic-, nonadrenergic nerves.
4. Chemical mediators (Serotonin et al) augment the seretory responses to nerve stimulations.
5. Substance P induces mucus secretion through both mucus squeezing and cell secretion, which are mediated by a peripheral cholinergic action.
6. No definite species and site defferences are observed in the secretory responces are observed in the secretory responses.
7. The secretory inhibitory action of epithelium is found in the secretory responses to choninergic, adrenergic, cycle AMP and substance P. This inhibitory factor is not a cycloxygenase nor a lipogeygenase product of arachidonic acid.
8. Secretory cell membranes have <Na^+> - <K^+> ATP ase activity which plays the major role in chloride and/or fluid secretion through submucosal gland.
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