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Influence of repeated administration of proline analogue to weanling rats

Research Project

Project/Area Number 60570359
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionTokyo Metropolitan Institute of Gerontology

Principal Investigator

KIDA Kozui  Researcher, Department of Experimental Pathology, Tokyo Metropolitan Institute of Gerontology., その他, 研究員 (90142645)

Co-Investigator(Kenkyū-buntansha) 太田 隆  東京都老人総合研究所, 基礎病理部, 研究員
松井 玲子  東京都老人総合研究所, 基礎病理部, 研究員
MATSUI Reiko  
OOTA Takashi  
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1985: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsLung development / Proline analogue / Elastin / Collagen / Mechanical stretch
Research Abstract

Together with observations by Emery (1970) and our previous experiments (Kida et al 1980, 1981), collagen and elastin play a key role in postnatal alveolar formation in this experimental protocol, weanling rats were treated with proline analogues which including cis-4-hydroxyproline and semicarbazide, respectively, and their morphology and pressure-curve measurements were compared with these of control animals. The lungs of cis-4-hydroxyproline treated animals did not reveal any remarkable changes in the lung function and morphology, respectively, except for the larger body weight than the control animals. Semicarbazide treated rats showed marked deformity of chest wall and showed surpression of normal alveolar formation. From these observation, chest wall movements was considered an additional role in the postnatal alveolar growth, Therefore, a rat model of chest wall restriction was made and their excised lungs was studied in term of lung function and morphology. These rats lung showed remarkable decreased of number of alveoli in the lung but each alveolar sizxe did not change in significant range.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 松井玲子,木田厚瑞,太田隆: 第26回日本胸部疾患学会. (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Reiko Matsui, Kozui Kida & Takashi Oota;: "Lung development in restrictive chest wall movements in weanling rats" 26th Anunal Meeting of Japan Thoracic Disease,. (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kozui Kida, Reiko Matsui & Takashi Oota;: "Postnatal alveolar formation was disordered by restriction of chest wall movements on weanling rats."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kozui Kida & Reiko Matsui;: "Effects of repeated administration of proline analogues on lung development in premature rats."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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