The Study of Total Body Potassium in Hypertensive patients

Research Project

Project/Area Number	60570400
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Circulatory organs internal medicine
Research Institution	The Third Department of Internal Medicine, Nagasaki University School of Medicine
Principal Investigator	DOI Yutaka (1986-1987) The 3rd Dept. of Int. Med. Nagasaki Univ. School of med. Associate, 医学部, 助手 (40128195) 鈴木伸 (1985) 長崎大学, 医学部, 助手
Co-Investigator(Kenkyū-buntansha)	SETO Shinzi The 3rd Dept. of Int. Med. Nagasaki Univ. School of Med. Associate, 医学部, 助手 (00136657)
Project Period (FY)	1985 – 1987
Project Status	Completed (Fiscal Year 1987)
Budget Amount *help	¥1,600,000 (Direct Cost: ¥1,600,000) Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000) Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000) Fiscal Year 1985: ¥700,000 (Direct Cost: ¥700,000)
Keywords	Hypertension / Serum potassium / Total body potassium Diuretics / 利尿剤 / 1カリウム補給 / 全身K量 / 血漿レニン活性 / 血漿アルドステロン濃度 / サイアザイド剤 / スピロノラクトン剤 / Na / KATPase
Research Abstract	The abnormality of potussium balance in essential hypertensive patients was studied by the measurement of total body potassium and serum potassium. The value of total body potassium in essential hypertension was lower than normal patients. The frequency of ventricular premature beats in hypertensive patients during thiazide treatment was high in low value of total body potassium. No significant decrease of serum potassium level was abserned during 60 months long term theropy. Although the levels of total body potassium did not change significantly during 24 months long term therapy, significant decrease of TBK was observed with thiazide therapy for more than 24 months as compared to that in the control group. The effect of potassium chloride potassium gluconate and spironolactone on the TBK and serum K during thiazide treatment was studied. Only spironolactone (75 mg/day) increased total body potassium and serium potassium during thiazide treatment.