| Project/Area Number |
60570409
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokai University School of Medicine |
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Principal Investigator |
YAMASHITA Yasuo Tokai Univ. Sch. of Med., Associate Professor, 医学部, 助教授 (30112783)
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| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Tsutomu Tokai Univ. Sch. of Med., 医学部, 助手 (50056321)
SUZUKI Keiko The Center for Adult Diseases, ベクトル心電図室長
戸山 靖一 大阪府立成人病センター, 研究所第一部長
TOYAMA Seiichi The Center for Adult Diseases
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Bidomain model / Anisotropy of heart muscle / Transmembrane potential / 心電図逆方向問題 |
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| Research Abstract |
We developed an equivalent electric source for anisotropic cardiac muscle based on the bidomain (bisyncytia) model and then discussed a method of reconstructing (macroscopic) transmembrane potentials over the heart surface.
First, we gave the extracelluar potential in a bounded inhomogeneous volume conductor in the form of an integral equation. It is possible to calculate the field potential from the transmembrane potential distribution in the heart, with a knowledge of geometrical property of muscle fibers as well as anisotropic conductivity of the heart muscle. Second, we discussed the method of estimating the (in situ) transmembrane potentials from the body surface map using the above equation. It is predicted that, if ratios of intracellular to extracellular conductivity along all directions are equal, the field potentials can be determined only using surface integral of the transmembrane potentials over the heart surface since the volume integral arising from the tissue anisotropy of cardiac muscle vanishes. Therefore, in that case, the in situ transmembrane potential distribution on the heart surface can be calculated uniquely from potential maps measured on the body surface.
We are developing a procedure of calculating the in situ transmembrane potentials from the body surface maps. It is expected that the in situ transmembrane potentials will be most effective in diagnosing of infarcted area and size since it is directly related to electric activity of heart muscle cells.
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