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Regional property of myocardial shortening and relaxation

Research Project

Project/Area Number 60570414
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKinki University

Principal Investigator

KATORI Ryo  Kinki University School of Medicine, 医学部, 教授 (40088521)

Co-Investigator(Kenkyū-buntansha) MORII Shigeo  Kinki University School of Medicine, 医学部, 助手 (10182213)
SAKEMOTO Isamu  Kinki University School of Medicine, 医学部, 助手 (80178623)
ODA Akio  Kinki University School of Medicine, 医学部, 講師 (20169303)
OSATO Shuichiro  Kinki University School of Medicine, 医学部, 講師 (70152105)
KANAMASA Ken  Kinki University School of Medicine, 医学部, 講師 (00122036)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsmyocardial shortening / asynergic contraction / myocardial infarction / myocardial ischemia / coronary artery / 心カテーテル
Research Abstract

We studied the regional unevenness of myocardial shortening and myocardial relaxation and the following results were obtained.
1. Asynergic myocardial contraction of ventricular premature beats. Asynergic myocardial contraction of ventricular premature beat evoked by epicardial electrical stimulation was assessed with small ultrasonic crystals implanted in the subendocardium of 15 open chest anesthetized dogs. The basic mechanism of asynergic contraction of ventricular premature beat was earlier shortening and earlier lengthening compared to LV pressure elevation at stimulation site, and the variations of the pattern of asynergic contraction were influenced by stimulation site and coupling time.
2. The changes in myocardial wall thickness in coronary reperfusion. The wall thickness was increased to 111.0% of the control immediately after reperfusion. This increase was transient and returned the control value at 6 hours. After that, it was again increased gradually up to the fourth day. Coronary reperfusion after 3 hour occlusion was effective to preserve myocardial function.
3.The effect of diltiazem on regional myocardial systolic function during reperfusion after brief coronary occlusion. The experiment was designed to examine the effect of diltiazem on the regional myocardial contraction during reperfusion after brief coronary occlusion in dogs. It was concluded that diltiazem can protect the ischemic myocardium during coronary occlusion and reperfusion from afterload reduction and the direct effect on metabolism in the ischemic myocardium.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 香取瞭: 日本医事新報. 3222. 26-32 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ken Kanamasa: Act Med Kinki Univ. 10. 235-244 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kinji Ishikawa: Tohoku J exp Med. 149. 107-117 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ryo Katori: "Coronary thrombolysis by intravenous large dose of urokinase in myocardial infarction" Nihon Iji-Shinpo. 3222. 26-32 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ken Kanamasa: "Impirment of regional left ventricular diastolic filling in myocardial infarction" Acta Med Kinki Univ. 10. 235-244 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kinji Ishikawa: "The beneficial effects of 40% and 100% <O_2> inhalations on acutelyinduced myocardial ischemia in dogs" Tohoku J exp Med. 149. 107-117 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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