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STUDIES OF CELLUAR IMMUNITY IN PATIENTSWITH NEPHROTIC SYNDROME

Research Project

Project/Area Number 60570450
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionNIHON UNIVERSITY

Principal Investigator

YUMIO KIKKAWA  DIVISION OF PEDIATRICS, DEPARTMENT OF MEDICINE, NIHON UNIVERSITY, 医学部・小児科, 講師 (20059463)

Co-Investigator(Kenkyū-buntansha) 稲毛 善四郎  日本大学, 医学部・小児科, 助手
三村 明朗  日本大学, 医学部・小児科, 助手
AKIRO KIMURA  DIVISION OF PEDIATRICS, DEPARTMENT OF MEDICINE, NIHON UNIVERSITY
ZENSHIRO INAGE  DIVISION OF PEDIATRICS, DEPARTMENT OF MEDICINE, NIHON UNIVERSITY
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥700,000 (Direct Cost: ¥700,000)
KeywordsHistamine H_2 receptor / HR^+ lymphocyte / procoagulang activity / Anti-idiotypic antibody / 4プレッサーT細胞 / イディオタイプー抗イディオタイプ・ネットワーク / N-glycolylGM_3 / Hanganatziu-Deicher抗体 / 特発性ネフローゼ症候群 / リンホカイン / ヒスタミン【H_2】【R^+】T細胞 / 遅延型過敏反応 / マクロファジーの白血球プロコアグラント活性 / シメチジン / サプレッサーT細胞 / イディオタイプ
Research Abstract

THE HISTAMINE-INDUCED INHIBITION OF E-ROSETTE FORMATION WAS EXAMINED USING LYMPHOCYTES FROM PATIENTS WITH NEPHROTIC SYNDROME. THE NUMBER OF HISTAMINE H2 RECEPTOR-BEARING T LYMPHOCYTES (HR^+ LYMPHOCYTES) IN NEPHROTIC SYNDROME PATIENTS AT INITIAL ONSET WAS MARKEDLY REDUCED, BUT WAS GENERALLY NORMALIZED BY STROID THERAPY. RECENTLY THE INVOLVEMENT OF HR+LYMPHOCYTES IN THE INHIBITION OF VARIOUS IMMUNE RESPONSES HAS BEEN SUGGESTED.
THE ALLO-SUPPRESSOR EFFECT OF NORMAL LYMPHOCYTES ON THE PRODUCTION OF LEUKOCYTE PROCOAGULANT ACTIVITY BY MONONUCLEAR LEUKOCYTES OF THE PATIENT IN RESPONSE TO PPD HAS BEEN STUDIED. THE PRODUCTION OF LEUKOCYTE PROCOAGULANT ACTIVITY WAS CONSISTENTLY ABOLISHED WHEN NORMAL T LYMPHOCYTES WERE MIXED WITH PATIENT'S LYMPHOCYTES. HOWEVER, PRETRAMENT OF THE NORMAL T LYMPHOCYTES WITH CIMETIDINE LED TO A DEMONSTRABLE LOSS IN THEIR ALLO-SUPPRESSOR PROPERTIES. THE RESULTS SUGGEST THE POSSIBILITY THAT THERE MAY BE AN ABNORMALITY IN THE HISTAMINE H2 RECEPTORS ON PATIENT'S SUPPRESSOR T LYMPHOCYTES.
A CIRCULATING FACTOR DESIGNATED LYMPHOCYTOTOXIN IN NEPHROTIC SYNDROME HAS BEEN INDICATED. HOW LYMPHOCYTOTOXINS ARE PRODUCED IN NTO FULLY UNDERSTOOD, BUT ANTI-IDIOTYPIC ANTIBODIES TO ANTIVIRAL OR BACTRRIAL ANTIBODIES ARE SUGGESTED TO STIMULATE CLONES TO PRODUCE AUTOANTIBODIES. OUR STUIDIES SUGGEST THE POSSIBILLITY THAT PATIENTS INITIALLY RESPOND TO THE GLYCOLIPIDS EXPRESSED ON LYMPHOLD CELLS, RESULTING IN PRODUCTION OF ANTI-GLYCOLIPID ANTIBODIES AS THE PRODUCT RELATED TO IDIOTPIC-ANTIIDIOTYPIC NEWROWK.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 吉川弓夫: 新小児医学大系. 12. 229-256 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 吉川弓夫: 小児内科. 17. 949-955 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 吉川弓夫: 小児科臨床. 39. 861-867 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M.Matsuura: Endocrinol.Japan.34. 587-593 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 三村明朗: 発表予定.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 吉川弓夫: 発表予定.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 稲毛善四郎: "5th Histamine Receptor Symposium" Excerpta Medica, 208 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y. KIKKAWA, ET AL.: "RENAL DESEASES AND IMMUNITY" SHONI NAIKA. 17. 949-955 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y. KIKKAWA: "MECHANISM OF IMMUNOSUPRESSIVE THERAPY IN PATIENTS WITH NEPHORTIC SYNDROME" THE JAPANESE JOURNAL OF NEPHROLOGY. 27. 928-933 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y. KIKKAWA: "RENAL DISEASES OF CHILDREN AND IMMUNITY" SHIN SHONIIGAKU TAIKEI. 12. 229-256 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y. KIKKAWA ET AL.: "LUPUS NEPHRITIS" JAPANED SE JOURNAL OF PEDIATRICS. 39. 861-867 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M. MATSUURA, ET AL.: "THYROID ANTIGEN-ANTIBODY NEPHRITIS: POSSIBLE INVOLBEMENT OF FUCOSYL-GMI AS THE ANTIGEN" ENDOCRINOL JAPON. 34. 587-593 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Z. INAGE ET AL.: EXCERPTA MEDICA. 5TH HISTAMINE RECEPTOR SYMPOSIUM (HISTAMINE H_2R^+-T CELLS IN ENPHROTIC SYNDROME), 29-37 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 吉川弓夫: 小児科臨糸. 39. 861-867 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 吉川弓夫: 腎と透析. 19. 1018-1020 (1985)

    • Related Report
      1986 Annual Research Report
  • [Publications] 吉川弓夫,栖原優: 日本腎臓学会誌. 28. 991-992 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 吉川弓夫,栖原優: Medical Postgraduates. 23. 621-627 (1985)

    • Related Report
      1986 Annual Research Report
  • [Publications] 吉川弓夫,三村明郎: 医学のあゆみ.

    • Related Report
      1986 Annual Research Report
  • [Publications] 稲毛善四郎 他: "5th Histamine Recptor Symposium" Excerpta Medica, 208 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 大野丞二: "厚生省特医疾患進行性腎障害調査研究班昭和60年度研究業積" 厚生省, 646 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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