| Project/Area Number |
60570450
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | NIHON UNIVERSITY |
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Principal Investigator |
YUMIO KIKKAWA DIVISION OF PEDIATRICS, DEPARTMENT OF MEDICINE, NIHON UNIVERSITY, 医学部・小児科, 講師 (20059463)
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| Co-Investigator(Kenkyū-buntansha) |
稲毛 善四郎 日本大学, 医学部・小児科, 助手
三村 明朗 日本大学, 医学部・小児科, 助手
AKIRO KIMURA DIVISION OF PEDIATRICS, DEPARTMENT OF MEDICINE, NIHON UNIVERSITY
ZENSHIRO INAGE DIVISION OF PEDIATRICS, DEPARTMENT OF MEDICINE, NIHON UNIVERSITY
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| Project Period (FY) |
1985 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1987: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Histamine H_2 receptor / HR^+ lymphocyte / procoagulang activity / Anti-idiotypic antibody / 4プレッサーT細胞 / イディオタイプー抗イディオタイプ・ネットワーク / N-glycolylGM_3 / Hanganatziu-Deicher抗体 / 特発性ネフローゼ症候群 / リンホカイン / ヒスタミン【H_2】【R^+】T細胞 / 遅延型過敏反応 / マクロファジーの白血球プロコアグラント活性 / シメチジン / サプレッサーT細胞 / イディオタイプ |
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| Research Abstract |
THE HISTAMINE-INDUCED INHIBITION OF E-ROSETTE FORMATION WAS EXAMINED USING LYMPHOCYTES FROM PATIENTS WITH NEPHROTIC SYNDROME. THE NUMBER OF HISTAMINE H2 RECEPTOR-BEARING T LYMPHOCYTES (HR^+ LYMPHOCYTES) IN NEPHROTIC SYNDROME PATIENTS AT INITIAL ONSET WAS MARKEDLY REDUCED, BUT WAS GENERALLY NORMALIZED BY STROID THERAPY. RECENTLY THE INVOLVEMENT OF HR+LYMPHOCYTES IN THE INHIBITION OF VARIOUS IMMUNE RESPONSES HAS BEEN SUGGESTED.
THE ALLO-SUPPRESSOR EFFECT OF NORMAL LYMPHOCYTES ON THE PRODUCTION OF LEUKOCYTE PROCOAGULANT ACTIVITY BY MONONUCLEAR LEUKOCYTES OF THE PATIENT IN RESPONSE TO PPD HAS BEEN STUDIED. THE PRODUCTION OF LEUKOCYTE PROCOAGULANT ACTIVITY WAS CONSISTENTLY ABOLISHED WHEN NORMAL T LYMPHOCYTES WERE MIXED WITH PATIENT'S LYMPHOCYTES. HOWEVER, PRETRAMENT OF THE NORMAL T LYMPHOCYTES WITH CIMETIDINE LED TO A DEMONSTRABLE LOSS IN THEIR ALLO-SUPPRESSOR PROPERTIES. THE RESULTS SUGGEST THE POSSIBILITY THAT THERE MAY BE AN ABNORMALITY IN THE HISTAMINE H2 RECEPTORS ON PATIENT'S SUPPRESSOR T LYMPHOCYTES.
A CIRCULATING FACTOR DESIGNATED LYMPHOCYTOTOXIN IN NEPHROTIC SYNDROME HAS BEEN INDICATED. HOW LYMPHOCYTOTOXINS ARE PRODUCED IN NTO FULLY UNDERSTOOD, BUT ANTI-IDIOTYPIC ANTIBODIES TO ANTIVIRAL OR BACTRRIAL ANTIBODIES ARE SUGGESTED TO STIMULATE CLONES TO PRODUCE AUTOANTIBODIES. OUR STUIDIES SUGGEST THE POSSIBILLITY THAT PATIENTS INITIALLY RESPOND TO THE GLYCOLIPIDS EXPRESSED ON LYMPHOLD CELLS, RESULTING IN PRODUCTION OF ANTI-GLYCOLIPID ANTIBODIES AS THE PRODUCT RELATED TO IDIOTPIC-ANTIIDIOTYPIC NEWROWK.
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