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Evaluation of chemotherapeutic effect upon 203 GL glioma in mice as studied by p-31-NMR spectroscopy.

Research Project

Project/Area Number 60570474
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionUniversity of Tokyo

Principal Investigator

NISHIKAWA Junichi  University of Tokyo, 医学部(分), 助教授 (00010322)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Keiichi  University of Tokyo, 医学部, 助手 (80188896)
ITOH Masamitsu  University of Tokyo, 医学部, 助手 (80176362)
YOSHIKAWA Kohki  University of Tokyo, 医学部, 講師 (40114714)
IIO Masahiro  University of Tokyo, 医学部, 教授 (80143486)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥800,000 (Direct Cost: ¥800,000)
KeywordsNMR / P-31-NMR spectroscopy / chemotherapy / Glioma / 【^(31)P】-NMR-スペクトロスコピー / 全身用MR装置
Research Abstract

The effect of chemotherapy against glioma in mouse was evaluated by P-31 NMR spectroscopy and flow cytometry. We found that administration of ACNUor tegafur at a dose less than LD-50 resulted in the partial suppression of the ratio of inorganic phosphate (Pi)/phosphocreatine (PCr) and phosphomonoester (PME)/creatine phosphate (PCr) after 24 or 48 hrs although these ratios are usually increased together with growth of tumors. Flow cytometric analysis of glioma in vivo showed an accumulation in cells containing tetraploid DNA by G-2-M block in 24-48 hrs after treatment However, the change occurred at a period slightly later than that of Pi/pcr ratio. On the other hand, histological change was noted at 8 days after administration. Hence, it is concluded that in vivo P-31-NMR spectroscopy can detect a change of metabolic pathways in tumors as early as 24-48 hr after administration of chemotherapeutic agents.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Masamitsu Itoh: The journal of Society of Magnetic Resonance in Medicine. 486 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masamitsu Itoh: Medical imaging technology. 5. 322-327 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 伊藤正光: 日医放学会雑誌. 48. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masamitsu Itoh: Radiation Medicine.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masamitsu Itoh: "Effectiveness of in vivo P-31-NMR in the diagnosis of chemotherapeutic effect upon glioma in mice." The Japanese Journal of Nuclear Medicine.23. 1299 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masamitsu Itoh: "Measurement of in vivo P-31-NMR in glioma for the evaluation of the effects of chemotherapy." The Journal of Nuclear Medicine.27. 970 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masamitsu Itoh: "Comparison of Kinetics pattern by P-31-NMR and flow cytometory following radiation and/or chemotherapy in a mouse glioma." The Journal of Society of Magnetic Resonance in Medicine.486 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masamitsu Itoh: "Clinical application of whole body MR." Medical image technology. 5. 322-327 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 伊藤正光,吉川宏起,西川潤一,飯尾正宏 ほか: 核医学. 23. 1299 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] M.Itoh;K.Yoshikawa;M.Iio,etal.: The Journal of Nuclear Medicine.27. 970 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2017-04-05  

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