| Project/Area Number |
60570483
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kitasato University |
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Principal Investigator |
MATSUNO Takashi School of Medicine, Kitasato University, 医学部, 講師 (80104537)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Kiyoko School of Medicine, Kitasato University, 医学部, 講師 (60050506)
KOISHI Masumi Faculty of Pharmaceutical Scienses, Science University of Tokyo, 薬学部, 教授 (70084423)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Bone Phantom / Artificial Bone / Bone Mineral / Microcapsule / CT-value / CT-scanner / Inorganic Wall Microcapsule / 骨塩定量 |
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| Research Abstract |
Computed tomography is a method for noninvasive assessment of bone mineral content. This method needs calibration phantoms. In this study, the calibration bone phantoms were made by the compression molding(20 t/ <cm^2> ) of multicore microcapsules or inorganic wall microcapsules( <I> and <II> -types) prepared. The multicore microcapsules were gelatin spheres of 0.5-2.0 mm diameters containing many titanium dioxide particles(rutile type, diameter: 0.3 <micro> m). <I> -type inorganic wall microcapsules were prepared by blending the titanium dioxide particles and nylon 12 microspheres(diameter: 5.0 <micro> m) at room temperature for 60 min with an automatic ceramic mortar and stirrer. <II> -type inorganic wall microcapsules were prepared by an impact type hybridization machine. The impacting pressure drives the titanium dioxide particles into nylon 12 microsphere surfaces and the resulting microcapsules are made up of inorganic compound(wall material) and organic compound(core material). The ratio of the inorganic compound to the organic compound can be arbitrarily controlled by changing the mixing ratio of both compounds. The materials developed in this study make possible to prepare the bone phantoms having arbitrary CT-values. The bone phantoms obtained were extremely homogeneous in regard to X-ray absorption and seemed very useful for evaluation the bone mineral content.
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