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Multi-domain study for the optimal subclassification of schizophrenia

Research Project

Project/Area Number 60570506
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionSaitama Medical School

Principal Investigator

TOYOSHIMA Ryoichi (1986)  Lecturer Department of neuropsychiatry, Saitama Medical School, 医学部, 講師 (00105917)

野口 拓郎 (1985)  埼玉医科大学, 医学部, 教授

Co-Investigator(Kenkyū-buntansha) OTA Toshio  Lecturer Department of Neuropsychiatry, Saitama Medical School, 医学部, 助手 (90160506)
MAESCHIRO Hisashi  Lecturer Department of Neuropsychiatry, Saitama Medical School, 医学部, 講師 (00118647)
MOTOMURA Hiroshi  Lecturer Department of Neuropsychiatry, Saitama Medical School, 医学部, 講師 (00049818)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1985: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsSchizophrenia / Subclassification / Computed Tomography / Ventricular Enlargement / Electroencephalography / Arousal Level / Positive Symptoms / 治療反応性
Research Abstract

The purpose of this study was to view correlations of multi-domain data of schizophrenic patients and to get an optimal concept of subtypes whose pathophysiological processes are supposed to be different from each other. Specifically, variables were limited to those of positive and negative symptoms, CT scans and polygraphic data on the alpha waves and the frequency of rapid eye movements with eyes closed which have been reported to reflect the level of arousal.
There was a negative correlation between the ventricular size and the score of treatment-resistant positive symptoms in twenty-five schizophrenics who have been treated well and were in a stable condition. There was a positive correlation between the ventricular size and the level of arousal in these subjects. Negative symptoms showed a tendency toward positive correlation with atrophic CT changes of cortices. In other twenty schizophrenics who were in an unstable, mostly exacerbated condition, there was a positive correlation between the ventricular size and positive symptom score. There was also a tendency toward positive correlation between the ventricular size and the level of arousal.
These findings suggest that there may be at least two subtypes of schizophrenia, one consists of patients who have relatively smaller ventricles, more treatment-resistant positive symptoms and lower level of arousal and that another type consists of those who have relatively larger ventricles, more treatment-responsive positive symptoms and higher level of arousal.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 大島浩伸,他: 精神薬療基金研究年報. 第17集. 225-229 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ota,Toshio,他: Acta Psychiatrica Scandinavica.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 豊嶋良一,他: "精神分裂病における脳室の大きさと陽性症状,覚醒レベルの関係-急性期と慢性期について-" 厚生省神経疾患研究委託費,精神分裂病の生物学的研究,研究主任 稲永和豊,昭和61年度報告書, (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ota,Toshio,他: "Biological heterogeneity of schizophrenia;Morphological and psychophysiological ertdence." Elsevier, (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ota,Toshio et al.: "Treatment-resistant chronicpsychopathology and CT scans in schizophrenia." Acta psychiatrica scandinavica.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ota, Toshio et al.: Elsevier. Biological heterogeneity of schigophrenia : Morphological and psychophysiological evidence., (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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