Clinical Immunological Study of Opportunistic Lymphoma
| Project/Area Number |
60570554
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Mie University |
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Principal Investigator |
SHIRAKAWA Shigeru The 2nd Dept. of Internal Medicine, Mie University School of Medicine Professor, 医学部, 教授 (20026850)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Toru The 2nd Dept. of Internal Medicine, Mie University School of Medicine, Lecturer, 医学部附属病院, 講師 (00144246)
KITA Kenkichi The 2nd Dept. of Internal Medicine, Mie University School of Medicine, Assistant, 医学部, 助手 (90169847)
TANAKA Isao The 2nd Dept. of Internal Medicine, Mie University School of Medicine, Lecturer, 医学部附属病院, 講師 (20115710)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | IM syndrome / EB virus / EBV genome / Opportunistic lymphoma / Immunological anomaly / Immunodeficiency |
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| Research Abstract |
Recently EBV-associated opportunistic lymphoma arising in the host with immunodeficiency state has been noticed remarkably although infectious mononucleosis (IM) syndrome related to EBV is usually self-limiting and good in prognosis due to immune defence mechanism of host. From a retrospective study on the antibody titers to EBV in 135 cases of lymphoreticular tumors 7 cases with consistently marked elevation of both anti-VCA and anti-EA titers were found. Evidently there were a few cases (around 5%) with lymphoreticular tumors, suggesting a possible participation of EBV to non-Burkitt's lymphoma. On a prospective study we have experienced with an adult patient with chronic EBV infection progressing to malignant lymphoma. The patient, 62-year-old man, noticed cervical lymphadenopathy with sore throat and leukocytosis (10% atypical lymphocytes), and strongly elevated EBV related antibodies. One and a half year later, he was acutely ill and febrile with abruptly enlarged lymphadenopathy.
… More
The lymph node biopsy was compatible to the diagnosis of malignant diffuse lymphoma, large cell type of B-cell origin. Also, the tumor cells were definitely EBNA positive, and EBV molecular hybridization study clearly indicated that the lymphoma cells had EBV genome. Immunological states of the patient were examined several times. The following characteristics were obtained as differed from the usual cases of IM. 1) An increased cell population of OKT8(+) and OKIa(-) in the peripheral T-cell subset. 2) Normal response in NK cell activity and mitogenic response of lymphocytes. 3) Suppressor T-cells could not be induced in vitro system of PWM-induced antibody response. 4) In the outgrowth inhibition assay used to evaluate EBV-specific cell mediated immunity, no successful inhibition was observed without addition of IL-2. Accordingly, the present study suggests that the patient might develop chronic IM to B-cell lymphoma due to an impairement of immunological surveillance against a consequence of infection. Less
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Research Products
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