| Project/Area Number |
60570611
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
MORIGUCHI Takahiko Associate Professor, Department of Plast. and Reconstr. Surg., 医学部, 助教授 (10111816)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Susumu Senior Resident, Department of Plast. Reconstr. Surg., 医学部形成外科, 助手 (00161365)
TANI Tasaburo Professor, Department of Plast. Reconstr. Surg., 医学部形成外科, 教授 (90098616)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Wound healing / Hypertrophic scar / 肥満細胞 / 瘢痕拘縮 |
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| Research Abstract |
The wound-healing process and change of mast cell population were studied in the skin of three Japanese monkeys.
In the split-thickness abraded wound of the skin in the monkey thigh, the scar developed quickly and there was a period when it took on features that can be described both clinically and histopathologically as characteristic of hypertrophic scars. The inflammation and features of hypertrophic scar disappeared rapidly, although this may be due to the difference in life span between humans and monkeys.
On the other hand, it has been reported that small experimental animals, such as mice, rats and rabbits, do not develop any hypertrophic scars. Therefore, it can be said that the monkey stands between humans and these small experimental animals insofar as the healing process of wound is concerned.
In skin biopsy specimens at the early stage of the wound healing, the number of mast cells was found to have decreased, but it increased gradually in the area close to the inflammatory changes and showed a marked increase at the final stage of inflammation in particular.
These findings suggest that there is some relationship between the increase in the volume of the connective tissue in scars and the number of mast cells.
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