| Project/Area Number |
60570629
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | TOHO University |
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Principal Investigator |
YOSHIO Toshifumi TOHO University, School of Medicine,Professor, 医学部, 教授 (80057497)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Katsuhiko TOHO University, School of Medicine, Assistant, 医学部, 助手 (90147546)
TSUJITA Kazunori TOHO University, School of Medicine, Assistant, 医学部, 助手 (60130374)
OHGAI Tadahisa TOHO University, School of Medicine,Lecturer, 医学部, 講師 (40057542)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | colo-rectal cancer / nuclear DNA content / grading of the cancer developping / prognosis of the colo-rectal cancer / 実験大腸癌 |
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| Research Abstract |
The nuclear DNA content was measured by microspectrophotometry in order to objectively evaluate malignancy of individual colo-rectal cancers,with particular concern to prognosis. Although the DNA content did not correlate to the location, diameter,invasion depth, histological type and staging,it was seen to be related to vessel invasion,lymphnode metastasis and liver metastasis. The DNA content in cases with venous invasion or liver metastasis was significantly greater than in those without the above-described findings.
Those cases in which modal value or mean value was presented in the 2C region showed higher five-year survial rates than did those presented in the 3C region or over.
The nuclear DNA content seemed to be correlated to the prognosis as well as various histopathological features.
The correlation between the developping of the experimental colo-rectal cancer in the rat and nuclear DNA content was observing,now.
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