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Fundamental Study for adoptive immunotherapy to the patients with malignant brain tumors.

Research Project

Project/Area Number 60570663
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

TAKEDA Norio (1986)  Niigata University, Brain Research Institute, Devision of Neurosurgery, 脳研究所, 助教授 (20150302)

吉田 誠一 (1985)  新潟大学, 医学部, 助手

Co-Investigator(Kenkyū-buntansha) TANAKA Ryuichi  Niigata University, Brain Research Institute, Devision of Neurosurgery, 脳研究所, 教授 (30018816)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1985: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsadoptive immunotherapy / Interleukine-2 / 抗腫瘍能 / malignant glioma / 悪性脳腫瘍患者
Research Abstract

We describe here the preliminary results of the local administration of antologous Lymphokine-activated killer (LAK) cells and the recombinant interleukin-2 (rIL-2) to the patients with malignant gliomas.
We treated 12 cases of malignant gliomas. The patients received both 1.8 to 21 x <10^8> LAK cells, and 8 to 16 x <10^4> units of rIL-2. Reduction of tumor size was observed in 4 patients. Improvement of symptoms was obtained in 7 of the 12 patients. No severe side effects occurred.
In the models of brain tumor-bearing rats, the local administration of LAK cells also seemed to be effective. Furthermore, activated killer cells, such as LAK cells, PHA-activated killer cells and their precursor cells were serologically studied for the recognition of their biological characteristics.
Further immunological study is required before its therapeutic value can be established.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (5 results)

All Other

All Publications (5 results)

  • [Publications] 吉田誠一: 脳と神経. 17. 1137-1143 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 吉田誠一: 脳と神経. 17. 1073-1078 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 吉田誠一: 癌と化学療法.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Seiichi Yoshida,et al.: "Analysis of Immunosuppressive Mechanism in the Patients with Malignant Brain Tumors." Brain and Nerve. 17. 1137-1143 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Seiichi Yoshida, et al.: "Clinicoimmunological Values of Measurement of IgG-Fc Receptor Positive T Cells in the Patients with Maligant Brain Tumors." Brain and Nerve. 17. 1073-1078 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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