| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
The role of renin-angiotensin(RA) system and thromboxane(TX) <A_2> on maintenance of renal circulation during reduced renal perfusion pressure was studied in dogs. The interaction between RA system and <TXA_2> was examined, before and during the renal artery pressure(RAP) was decreased to 60 mmHg. Intrarenal arterial administration of angiotensin II(A-II) reduced RBF, but increased GFR, when mean renal arterial pressure was decreased to 60mmHg. On the contrary, the changes of RBF and GFR following A-II infusion were similar to non-treated dogs at normal RAP, but during reduced RAP A-II infusion decreased GFR in dogs pretreated with <TXA_2> synthetase inhibitor, UK-38485. The <TXB_2> production by renal cortex in hypoperfused kidney increased to 2.7 fold of that at normal RAP. However, <TXB_2> production did not increase during reduced RAP in captopril pretreated kidney. These results suggest that RA system and prostanoids, especially <TXA_2> , are essential factor to maintain GFR at low RAP.
The interaction of leukotriene(LT) and catecholamine(CA) in endotoxin shock was studied in rats. Hyperdynamic state following E.coli lipopolisaccaride(LPS) administration was disappeared by depletion of CA. LTs antagonist(FPL) antagonized the hypotension partially following LPS administration in CA depleted rats. Pretreatment of FPL combined with platelet activating factor(PAF) antagonist(CV-3988) inhibited the change of microvascular permeability following LPS administration, and increased survival rate. These results suggest that the inhibition of LTs and PAF activity is useful for the treatment of shock.
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