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Subrenal capsule assay for testing the effectiveness of anticancer drugs

Research Project

Project/Area Number 60570740
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionUniversity of Tsukuba

Principal Investigator

NEMOTO Ryosuke  University of Tsukuba , Institute of Clin. Med.,Assistant Proffesor., 臨床医学系, 講師 (10006801)

Co-Investigator(Kenkyū-buntansha) ISHIKAWA Satoru  University of Tsukuba, Institute of Clin. Med., Assistant Proffesor., 臨床医学系, 講師 (70168194)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1986: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1985: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordssubrenal capsule assay / sensitivity test / anticancer drug / マウス / 尿路悪性腫瘍
Research Abstract

1. The histological changes induced by human bladder tumor xenografts following their implantatipn in the subrenal capsule of immunocompetent mouse wew compared. (1) infiltration of the tumor with mononuclear cells and neutrophils began on day 4,(2) pretreatment with cyclophosphamide before implantation reduced cell infiltration into the xenografts, (3) complete rejection of the tumor on day 8.
2. The sensitivity to commonly used chemotherapeutic agents were tested against genitourinary tract cancers. Groups of tumor-bearing mice were treated daily for 3 days. Sensitivity for assays were assesed on day 4 by histological score. Of the 19 cases evaluated, 20 % demonstrated significant oncolytic activity.
These results suggested that a clinically relevant chemosensitivity assay might enhance the selection of appropriate therapy.

Report

(1 results)
  • 1986 Final Research Report Summary

Research Products

(9 results)

All Other

All Publications (9 results)

  • [Publications] 根本良介: 癌と化学療法. 13. 1235-1240 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 根本良介: 日本癌治療学会誌. 11. 2243-2248 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Nemoto,R.: Procceding of the 14th international Congress of Chemotherapy. 369-370 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 根本良介: 日本泌尿器科学会誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ryosuke Nemoto: "Subrenal capsule assay for testing the effectivness of anticancer drugs," Jpn. J. Cancer Chemother.13. 1235-1240 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ryosuke Nemoto: "Histopathological changes induced by human bladder cancer xenografts implanted under the kidney capsule of immunocompetent mice." J. Japan Soc. Cancer Ther.,. 21. 75-80 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ryosuke Nemoto: "Histopathological changes of human bladder tumor xenograft in subrenal capsule assay." Procceding of the 14th international Congress of Chemotherapy. 369-370 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ryosuke Nemoto: "Subrenal capsule assay- histology and size of xenografts" J. Japan Soc. Cancer Ther.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ryosuke Nemoto: "Subrenal capsule assay in human urological cancer" Japan J. Urology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-30   Modified: 2016-04-21  

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