The Study on Materno-Infantile Vertical Transmission of ATLV in Human and Monkey

Research Project

Project/Area Number	60570768
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	Faculty of Medicine, University of Chiba
Principal Investigator	INABA Noriyuki Department of Obstetrics and Gynecology, Faculty of Medicine, University of Chiba, 医学部, 講師 (70114238)
Co-Investigator(Kenkyū-buntansha)	時田尚志千葉県癌センター, 動物部門, 部長 FUKAZAWA Ichio Faculty of Medicine, University of Chiba, 医学部産婦人科, 文部教官助手 (00189911) TOKITA Hisashi Chiba Cancer Center
Project Period (FY)	1985 – 1986
Project Status	Completed (Fiscal Year 1986)
Budget Amount *help	¥1,900,000 (Direct Cost: ¥1,900,000) Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000) Fiscal Year 1985: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords	ATLV / HTLV-I / Pregnant Carrier / Vertical Transmission / Sexual Transmission / STD / Vaccination
Research Abstract	This study was done to evaluate the possible frequency of vertical trnasmission of ATLV from ATLV carrier women to their offspring and develop possible means for preventing the vertical transmission. The preliminary results are as follows: 1. The ATLV carrier rates of pregnant women reached 6.9 and 5.9 % respectively in Okinawa and Iwate Prefectures, while the rate was only 0.8% in Chiba Prefecture. And four hundred women ranging 6 - 90 years old in Iwate Prefecture were screened for ATLA-Ab and 29 (7.3%) revealed ATLA-Ab positive. These findings indicate ATLV is epidemic not only in Okinawa but also in Iwate Prefecture. In addition, the percentages showed a certain trend to increase with increased ages, reaching 33.3% in 12 women beyond 80 years old. 2. The 49 individuals with a pregnant woman as a familial member were tested for ATLV-Ab to investigate the possible familial clustering of ATLV. In total, the positive rate was 59.2 %. In particular, the groups of mother, grandmother and siblings revealed high positive rates (80.0, 66.7 and 68.4%), suggesting a certain possibility of vertical transmission. Furthermore, the high percentages were observed even in the groups of grandfather and husband (40.0 and 42.9 %), indicating the possible sexual transmission of ATLV. 3. Of 9 infants born to carrier mothers, seven developed ATLA-Ab positive in their umbilical cord sera. The titers of ATLA-Ab decreased gradually, but remained positive during the first 6 months in these 7 infants. 4. There were no ATLV carriers in the 45 patients with uterine cervical cancer and 30 cases with ovarian cancers, which indicates no intimate correlation between ATLV carrier-state and development of malignant neoplasms.