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Research on pathogenesis of the endometriosis

Research Project

Project/Area Number 60570772
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

KAWASHIMA Yoshiro  Department of Obstetrics & Gynecology, 医学部, 教授 (90022764)

Co-Investigator(Kenkyū-buntansha) SUMIMOTO Kazuhiro  Department of Obstetrics & Gynecology, 医学部, 助手 (30126817)
HAYATA Takashi  Department of Obstetrics & Gynecology, 医学部, 講師 (60135259)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1985: ¥400,000 (Direct Cost: ¥400,000)
Keywordsendometriosis / adenomyosis electronmicroscope / コラーゲン成分 / CA125 / 保存療法 / 不妊症 / ホルモン療法 / 月経困難症 / 内性子宮内膜症 / 外性子宮内膜症
Research Abstract

Although we encounter endometriosis not infrequently, the exact nature of this entity has not yet been determined. In order to study the morphogenesis of this disease,we chose the adenomyotic glandular epithelium as distinct ectopic glands and examined them in the electronmicroscope, comparing them with the proliferative phase of the endometrium and the uterine body adenocarcinoma.
Five cases were selected from 76 histologically proven cases of adenomyosis at our university. Epon blocks were ultrasectioned with a Porter MT II microtome, stained with uranium acetate and lead, and observed in a JEM 100 C electronmicroscope.
Although there are few similarities to endometrial cancer, these findings would suggest that adenomyosis may be an intermediate between the normal proliferative endometrium and endometrial cancer.
The patients with endometriosis have shown a significant increase in frequency in our country. In the recent years, the incidence of endometriosis in gynecological outpatients … More is probably 3%. In infertile patients, endometriosis has been demonstrated by laparoscopy in 20-30% of cases. The pregnancy rate of women with endometriosis has been noted to be 80-85% in the internal endometriosis and 50-60% in the external endometriosis. The risk of infertility is greater in women with external endometriosis than in women with internal endometriosis.
Conservative treatment of endometriosis is associated with improvement infertility and the post-treatment pregnancy rate has become an acceptable indicator of the effectiveness of therapy. The choice of therapeutic approach depends on several factors including age of the patient, extent of the disease, extent and location of pelvic adhesions and other coexisting infertility factors.
Following conservative treatment of endometriosis, spontaneous conceptions occur in many patients with previously long-standing sterility. In many studies, the corrected pregnancy rates after conservative treatment are 30-60%. Most conceptions are observed within one year after completion of treatment. Less

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 早田隆,川島吉良: 産婦の世界. 39. 25-30 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 水口弘司,高見澤裕吉,川島吉良,杉本修: 産婦の世界. 39. 89-118 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 川島吉良: 産婦の実際. 36. 1679-1683 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 水口弘司,高見澤裕吉,川島吉良,杉本修: 産婦の世界. 39. 85-106 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 早田隆: 日産婦関東連会報. 46. 67-69 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 早田隆,三宅若葉,嵯峨こずえ,金山尚裕,小林浩,川島吉良: 産と婦. 54. 33-38 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 川島吉良: "子宮内膜症の発生病理に関する研究 昭和60年度〜昭和62年度文部省科学研究費補助金(一般研究C)研究成果報告書" 川島吉良, 272 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 川島良吉編: "産婦人科Mook26" 金原出版, 278 (1983)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yoshiro KAYASHIMA: "Conservative surgery of endometriosis, its application and limits" Obstetrical and Gynecological Practice. 36. 1679-1683 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takashi HAYATA, Wakaba MIYAKE, Kozue SAGA, Naohiro KANAYAMA, Hiroshi KOBAYASHI, Yoshiro KAWASHIMA: "Endometriosis and CA125" Obstet Gynecol (Tokyo). 54. 33-38 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hiroshi KOBAYASHI, Naohiro KANAYAMA, Takashi HAYATA, Yoshiro KAWASHIMA: "Usefulness of Measurement of Serum CA125 Levels in Diagnose and Treatment of Endometriosis" Acta Obst Gynaec Jpn. 39. 1054-1060 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takashi HAYATA, Hiroshi KOBAYASHI, Yoshiro KAWASHIMA: "A case of adenocarcinoma arising in ovarian chocolate cyst" Obstet Gynecol (Tokyo). 54. 105-108 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takashi HAYATA, Yoshiro KAWASHIMA: "Hormonal therapy of endometriosis (Danazol, Buserelin etc)" Obstet Gynecol (Tokyo). 54. 139-143 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takashi HAYATA, Yoshiro KAWASHIMA: Clinicopathologic study of eight cases of uterine body cancers associated with endometriosis interna (uterine adenomyosis). Am J Obstet Gynecol, 663-666 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 川島吉良: 臨床婦人科産科. 40. 59-61 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 川島吉良,早田隆,小林浩,嵯峨こずえ,三宅若葉: 産婦人科治療. 53. 245-252 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 川島吉良: 日本産婦人科学会雑誌. 38. 1243-1249 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 早田隆,川島吉良: 産科と婦人科. 54. 609-613 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Takashi,HAYATA.;Yoshiro,KAWASHIMA.: Am J Obstet Gynecol. 156. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 早田隆,三宅若葉,小林浩,川島吉良: 産科と婦人科. 54. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 編集 山村雄一,織田敏次,五島雄一郎,清水喜八郎,川島吉良-月経困難症: "薬物療法の実際 第1編 薬物療法" アサヒメデイカル,東京, (10511155 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 編集 岩田正晴,熊坂高弘,川島吉良: "産婦人科Q&A(子宮内膜症の診断と治療 子宮内膜症のホルモン療法)" 金原出版株式会社,東京, 543 (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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