The Relationship between Diabetic Retinopathy and ThromboxaneA2, and Prostacyclin.

Research Project

Project/Area Number	60570842
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Ophthalmology
Research Institution	Tokyo Women's Medical College Diabetes Center
Principal Investigator	KAMEYAMA Kazuko Tokyo Women's Medical College, 医学部, 助教授 (70096577)
Co-Investigator(Kenkyū-buntansha)	KIDOGUCHI Hiroshi Tokyo Women's Medical College, 眼科, 助手 (30204936) OHI Ikuko Tokyo Women's Medical College, 眼科, 講師 (90130236) 福田敏雅東京女子医大糖尿病センター, 眼科, 講師 FUKUDA Toshimasa Tokyo Women's Medical College
Project Period (FY)	1985 – 1986
Project Status	Completed (Fiscal Year 1986)
Budget Amount *help	¥1,700,000 (Direct Cost: ¥1,700,000) Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000) Fiscal Year 1985: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords	Diabetic retinopathy / ThromboxaneA2 / ThromboxaneB2 / Prostacyclin / 6-Ketoprostagrandin / トロンボキサン【B_2】 / プロスタサイクリン / 6-ケトプロスタグランディン
Research Abstract	It has been accepted that obstruction of retinal capillary causes the proliferative diabetic retinopathy. The microthrombosis is assumed to be partially due to the overproduction of thromboxane A2(TXA2) in platelet and reduction of prostacyclin(PGI2) in endotherial cells of vessel. We evaluated the plasma level of thromboxane B2(TXB2) which is the stable metabolite of TXA2 and 6-Keto prostagrandin (6-KetoPGF1 <alpha> ) which is the stable metabolite of PGI2 as well as serum HbAl level in 133 diabetic patients with or without diabetic retinopathy. results 1. There was a marked correlation between TXB2 and 6-Keto PGF1 <alpha> levels in blood. 2. The levels of TXB2 and PGF1 <alpha> were mutually related to HbAl level. 3. The plasma level of TXB2 was significantly higher in the patients with active diabetic retinopathy than with inactive one. The 6-KetoPGF1 <alpha> , increased only before retinopathy progressed to active proliferative stage. 4. The range of obstruction of retinal vessels was correlated with the level of TXB2 but not with 6-KetoPGF1 <alpha> . These findings suggested that initialy TXA2 and PGI <alpha> levels in plasma increased concomitantly but when TXA2 became predominant over PGI2, the retinopathy developed into active proliferative retinopathy.