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The Relationship between Diabetic Retinopathy and ThromboxaneA2, and Prostacyclin.

Research Project

Project/Area Number 60570842
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionTokyo Women's Medical College Diabetes Center

Principal Investigator

KAMEYAMA Kazuko  Tokyo Women's Medical College, 医学部, 助教授 (70096577)

Co-Investigator(Kenkyū-buntansha) KIDOGUCHI Hiroshi  Tokyo Women's Medical College, 眼科, 助手 (30204936)
OHI Ikuko  Tokyo Women's Medical College, 眼科, 講師 (90130236)
福田 敏雅  東京女子医大糖尿病センター, 眼科, 講師
FUKUDA Toshimasa  Tokyo Women's Medical College
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsDiabetic retinopathy / ThromboxaneA2 / ThromboxaneB2 / Prostacyclin / 6-Ketoprostagrandin / トロンボキサン【B_2】 / プロスタサイクリン / 6-ケトプロスタグランディン
Research Abstract

It has been accepted that obstruction of retinal capillary causes the proliferative diabetic retinopathy. The microthrombosis is assumed to be partially due to the overproduction of thromboxane A2(TXA2) in platelet and reduction of prostacyclin(PGI2) in endotherial cells of vessel.
We evaluated the plasma level of thromboxane B2(TXB2) which is the stable metabolite of TXA2 and 6-Keto prostagrandin (6-KetoPGF1 <alpha> ) which is the stable metabolite of PGI2 as well as serum HbAl level in 133 diabetic patients with or without diabetic retinopathy.
results
1. There was a marked correlation between TXB2 and 6-Keto PGF1 <alpha> levels in blood.
2. The levels of TXB2 and PGF1 <alpha> were mutually related to HbAl level.
3. The plasma level of TXB2 was significantly higher in the patients with active diabetic retinopathy than with inactive one. The 6-KetoPGF1 <alpha> , increased only before retinopathy progressed to active proliferative stage.
4. The range of obstruction of retinal vessels was correlated with the level of TXB2 but not with 6-KetoPGF1 <alpha> .
These findings suggested that initialy TXA2 and PGI <alpha> levels in plasma increased concomitantly but when TXA2 became predominant over PGI2, the retinopathy developed into active proliferative retinopathy.

Report

(1 results)
  • 1986 Final Research Report Summary

Research Products

(2 results)

All Other

All Publications (2 results)

  • [Publications] 木戸口裕: 眼科臨床医報. 81. 1081-1087 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] HIROSHI KIDOGUCHI: "The Relationship between Diabetic Retinopathy and Thromboxane A2 and Prostacyclin" Japanese Review of Clinical Ophthalmology. 81. 1081-1087 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-30   Modified: 2017-04-05  

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