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Potentiality of periodontal tissue regeneration on periodontal defect.

Research Project

Project/Area Number 60570895
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionKAGOSHIMA University

Principal Investigator

YOKOTA Makoto  KAGOSHIMA University of Dental School, 歯学部, 助教授 (40107298)

Co-Investigator(Kenkyū-buntansha) HAMADA Atsuko  KAGOSHIMA University of Dental School, 歯学部, 助手 (20180937)
KUROKI Kiyoshi  KAGOSHIMA University of Dental School, 歯学部, 助手 (80170108)
NAKAYAMA Kiyotaka  KAGOSHIMA University of Dental School, 歯学部, 助手 (20164361)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1986: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1985: ¥800,000 (Direct Cost: ¥800,000)
Keywordsperiodontal ligament / root resorption / new cementum / クエン酸
Research Abstract

In order to find how width of the periodontal defects occuring from ankylosis and root resorption, the two type of surgical defect on root surfaces were produced. 6 beagle dogs (1-2 years old) were used for study.
First type of defect was around the middle of the root facially. : U-shaped incision was made at the mucogingival line and the flap was raised on the coronal site. The periodontal tissue were completely removed in a squared area 2 2mm, 4 4mm, 6 6mm from the root surfaces. Second type of defect was at cirvical site : Incision was made at the gingival sulcus, and all of the periodontal tissue were completely removed in a square 6 6mm from the cirvical root surface, and citric acid was applicated.
The flap on the both type of defects were closed at original level. The dogs were sacrificed 2 and 3 months and it was examined a histologically. The first type of the 2 2mm squared defects were completely regenerated by the periodontal tissue. Periodontal regeneration of 4 4mm and 6 6mm squared defects were shown incompletely. Alveolar bone didn't regenerate throughout the defects. New cementum wasn't seen only at the part of a defect border. The connective tissue fibers lying parallel to the root surfaces at the no cementum site. But ankylosis and active root resorption wasn't seen at any size of defect. On the other hand, in the both type of cirvical defects (citric acid and just planed part) remoted from the influence of periodontal ligament and junctional epithelium didn't enhance new fibrous attachment and new cementum formation. And active root resorption was the predominant features of healing root surfaces facing gingival tissue. Our proposal were as follows. 1) Ankylosis and active root resorption wasn't occured in the defects removed the periodontal tissue. 2) Active resorption on the cirvical defect showed a high incidense as compared with the middle of the root surface defect.

Report

(1 results)
  • 1986 Final Research Report Summary

URL: 

Published: 1987-03-31   Modified: 2016-04-21  

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