| Project/Area Number |
60870072
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
外科・放射線系歯学
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| Research Institution | Hospital attached to the Osaka University Faculty of Dentistry |
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Principal Investigator |
TAKESHI ISHIDA Hospiral, Osaka univ. Faculty of Dent. Associate Professor, 歯学部附属病院, 助教授 (50028768)
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| Co-Investigator(Kenkyū-buntansha) |
HAJIME FUc@hIHATA 大阪大学, 歯学部, 教授 (70028728)
大西 徹郎 大阪大学, 歯学部附属病院, 医員
藤本 雅彦 大阪大学, 歯学部附属病院, 医員
福田 康夫 大阪大学, 歯学部附属病院, 医員
TESURO ONHSHi Hospital, Osaka Univ. Faculty of Dent., Resident
YASUO FUKUDA Hospital, Osaka Unive. Faculty of Dent., Resident
MASAHIKO FUJImOTOO Hospital, Osaka Univ. Faculty of Dent., Resident
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| Project Period (FY) |
1985 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1985: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | Oral cancer / Vital examination / Angiogenic activity / 毛細血管増生能(Angiogenic activity) / コルポスコピー / 毛細血管増生能 / Angiogenic activity |
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| Research Abstract |
Colposcoipic examination contributes to taise teliability of diagnosis of cervial carcinoma and carcinoma in situ. This developemtnal scientific resarch was proposed to apply th colposcopy fdor diagnosis of oral cancer and precancerous lesion This application id based on similatiry of tissue between the cervix and oral mucosa. At first, model changes of the colposcope suitable for oral examination, i.e., change of magnifactfion rate, improvement of control apparatus of scopr anglt, were performed. From the trial use of this reformed colposcope, there were difficulties in foxued depth and image sharpness on the occation of connecting optimal camera to the scope. These problems were improved by connecting TV camera instead of optimal camera. Teh TV camera-scopr system cought mormal pattern of capillaries on the vatrious parts of oral mucos( labial, buccal, lingual and gingival mucosa) in nromal 18 persons. In oral mucosal lesions of 35 cases, xapillary pattern of lichen planus indecated almost same pattern as the control. cases of squeamous cell carcinoma indicated abnormal parretn of siarrangement of capillary loop and dialatation of capillary vessel. It was dffficult to observe capillary pettern in the cases of hyperkeratortic and acanthotic lesions of leukoplakia, carcinoma in siitu, early invasive carcinoma and advances S. C.C.. Espercially in linguql esions, is was more difficult to obsarve if becasue of lingual movement and saliva.
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