Establishment of Quality Evaluation Method for Crude Drugs by GC-MS
| Project/Area Number |
60870077
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHIKAWA Masayuki Associate Professor, Faculty of Pharmaceutical Sciences, Osaka University, 薬学部, 助教授 (90116129)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBUYA Hirotaka Research Associate, Faculty of Pharmaceutical Sciences, Osaka University, 薬学部, 助手 (50116042)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1986: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1985: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | GC-MS / Crude Drug / Quality Evaluation / Processing / Ginseng; Capillaris / Zedoary / 莪じゅつ / 生姜 / 菌ちん蒿 |
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| Research Abstract |
It is the purpose of this research project to establish a quality evaluation method for crude drugs (e.g. ginseng, capillaris, zedoary, ginger), which are important ingredients of Chinese traditional herb formulae, by means of gas liquid chromatography-mass spectrometry.
1) Ginseng: The difference of lipophilic constituents between "white ginseng" and "red ginseng", which were prepared by processing of the same Panax ginseng root, has been clarified by GC-MS analysis.
2) Capillaris: The method for qualitative and quantitative analysis of choleretic principles in capillaris has been established by GC-MS.
3) Zedoary: The essential oil constituents in zedoaries originated in China, Taiwan, and Yakushima (Japan) were analized by GC-MS. It has been found that each essential oil gives a characteristic reconstructed ion current (RIC) chromatogram.
4) Ginger: Many useful findings have been obtained in comparison of GC-MS data for bitter principles of gingers originated in Kohchi Pref., Shizuoka Pref., China, and Vietnam.
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Report
(2 results)
Research Products
(7 results)
