| Project/Area Number |
60870095
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
応用薬理学・医療系薬学
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| Research Institution | School of Medicine, Keio University |
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Principal Investigator |
KATO Ryuichi Professor, School of Medicine, Keio University, 医学部, 教授 (40112685)
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| Co-Investigator(Kenkyū-buntansha) |
YASUMORI Toshio Assistant prof., School of Medicine, Keio University, 医学部, 助手 (70182350)
YAMAZOE Yasushi Associate prof., School of Medicine, Keio University, 医学部, 講師 (00112699)
KAMATAKI Tetsuya Professor, Faculty of Pharmaceutical Sciences, Hokkaido University
OKAWA Hideo Chief researcher, Sumitomo Chemical Co.Ltd.
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 1986: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1985: ¥6,400,000 (Direct Cost: ¥6,400,000)
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| Keywords | cytochrome P-450 / cloning / drug metabolism / クローニング / 遺伝子クローニング |
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| Research Abstract |
Cytochrome P-450 plays an important role in detoxification of drug and other xenobiotics. To develop the medical use of the enzyme, we have investigated the structures of human liver cytochrome P-450 which provide the basis for the production by a genetic engineering methodology informationf of a major human liver cytochrome P-450 was obtained from <lambda> gtll pharge cDNA livrary by the use of the specific antibodies.
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