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The requirement and function of magnesium.

Research Project

Project/Area Number 61300008
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionKyoto University

Principal Investigator

ITOKAWA Yoshinori  Faculty of Medicine, Kyoto University, Professor, 医学部, 教授 (80025593)

Co-Investigator(Kenkyū-buntansha) 田沼 悟  福島県立医科大学, 助教授 (90117672)
KOBAYASHI Akio  Showa Medical University, Professor, 医学部, 教授 (30153589)
MORII Hirotoshi  Osaka City University School of Medicine, Professor, 医学部, 教授 (40046983)
YANO Hideo  Faculty of Agriculture, Kyoto University, Associate Professor, 農学部, 助教授 (20026587)
五島 孜郎  東京農業大学, 農学部, 教授 (60078079)
KIMURA Mieko  Faculty of Medicine, Kyoto University, Associate Professor
YOSHIDA Masahiko  Juntendo Medical University, Assistant Professor
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 1987: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1986: ¥5,700,000 (Direct Cost: ¥5,700,000)
Keywordsrequirement of magnesium / function of magnesium / survey studies / animal experiments / 大動物実験 / 臨床実験 / カルシウム / マグネシウム比 / 結石 / 糖尿病 / 高血圧 / ビタミンD / 未熟児
Research Abstract

The cooperative research was carried out to clarify the requirement and function of magnesium through survey studies, animal experiments and clinical studies. By the survey study, it has been clarified that the average daily intake of magnesium for Japanese is 155-300 mg/day and this value was lower than the unauthorized dietary allowance calculated by the balance studies. In animal experiments, the following results were obtained. Increased dietary phosphorus resulted in significantly decrease in serum magnesium and addition of magnesium recovered this condition. On the other hand, phosphorus dificiency caused increase in urinary excretion of magnesium. The ability of basic common tubular transport system on magnesium is unchanged in the setting of renal insufficiency. Magnesium load to stroke-prone SHR stimulated to excrete urinary magnesium and calcium. The effect of magnesium deficiency was remarkable for lactating mother rats. An experiment using sheeps revealed that parathyroid hormone and calcitonin regulate magnesium concentration in body fluids. By clinical studies, the following results were obtained. Magnesium levels in lymphocyte were low in very low birth weight infant and infusion therapy containing magnesium recovered this condition. Moderate magnesium deficiency was observed in the fifty to sixty aged group. Serum magnesium level in patients with idiopathic nephrotic syndrome werelow and this value gradually elevated by corticosteroid theraphy. Hypermagnesemia was observed in patients with chronic renal failure. Intracellular magnesium ion and their clinical significance were investigated.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 糸川 嘉則: 循環器科. 21. 534-541 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 五島 孜郎: マグネシウム. 5. 1-8 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 吉田 政彦: マグネシウム. 6. 1-7 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 田沼 悟: マグネシウム. 6. 51-62 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 吉丸 清道: マグネシウム. 6. 139-145 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y. Itokawa: Magnesium. 6. 48-54 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 糸川 嘉則: "Mgと循環器症患" メディカル・トリビューン, 119 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] ITOKAWA, Yoshinori: "Nutritional problems on magnesium." Junkankika. 21. 534-541 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] GOTO, Shiro: "Magnesium intake and its balance in Japanese." Magnesium. 5. 1-8 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] YOSHIDA, Masahiko: "Magnesium metabolism in chronic renal failure." Magnesium. 6. 1-7 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] TANUMA, Satoru: "Magnesium metabolism in extremely immature baby." Magnesium. 6. 51-62 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] YOSHIMARU, Kiyomichi: "Clinical significance of intraerythrocytic ionized magnesium." Magnesium. 6. 139-145 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] ITOKAWA, Yoshinori: Mg and cardiovascular diseases.Medical tribune, 119 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 糸川嘉則: 労働の科学. 40. 13-17 (1985)

    • Related Report
      1986 Annual Research Report
  • [Publications] 五島孜郎: マグネシウム. 5. 1-8 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 佐孝晶子: マグネシウム. 5. 61-66 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 吉田政彦: マグネシウム. 5. 67-74 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 斉藤昇: マグネシウム. 5. 75-82 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 石井伴房: マグネシウム. 5. 89-93 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 糸川嘉則: "Mgと循環器疾患" メディカルトリビューン, 119 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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