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Chemical Classification and Biological Activity of Fish Pituitary Glycoprotein Hormones

Research Project

Project/Area Number 61300014
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionKitasato University

Principal Investigator

KAWAUCHI Hiroshi  Kitasato University, School of Fisheries Sciences, 水産学部, 教授 (70050523)

Co-Investigator(Kenkyū-buntansha) AOKI Takasi  Miyazaki University, Faculty of Agriculture, 農学部, 助教授 (00051805)
NAITO Nobuko  Showa University School of Medicine, 医学部, 講師 (30053903)
NAKAI Yasumitsu  Showa University School of Medicine, 医学部, 教授 (60053807)
HIRANO Tetsuya  University of Tokyo, Ocean Research Institute, 海洋研究所, 教授 (70013571)
NAGAHAMA Yoshitaka  National Institute for Basic Biology, Laboratory of reproductive Biology, 教授 (50113428)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 1988: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1986: ¥7,500,000 (Direct Cost: ¥7,500,000)
Keywordsgonadotropin / steroidogenesis / vitellogenesis / ovulation / spermatogenesis / spermiation / estradiol-17 / 17 ,20 -diOHprog / 11-ketotestosterone / thyroid hormone / thyroxine, metamorphosis / silvering, salmon / subunits / cDNA / cAMP / GTH産生細胞 / GTHの2元性 / サケ科魚類 / 免疫遺織染色 / 脳下垂体 / 細胞 / 配偶子形成期 / 成熟期 / 酵素免疫測予法 / 分泌調節 / ステロイド産生能 / ラジオイムノアッセイ / 卵黄形成 / 卵成熟 / 単離 / 一次構造 / シロサケ / アマゴ / 下垂体 / 抗体 / 糖タンパク
Research Abstract

Duality of teleost gonadotropins (GTHs): Two chemically distinct GTHs homologous to mammalian GTHs were isolated form salmon, carp and bonito pituitary glands, designated GTH I and GTH II and their cDNAs were cloned. They are composed of and subunits. Sequence studies show that two -subunits have approximately 30% homology and suggest that the divergence of the GTH gene took place earlier than the time of divergence of teleosts from the mainline of evolution leading to tetrapods. Salmon GTH I and GTH II were equipotent in stimulating estradiol production, whereas GTH II appears to be more potent in stimulating 17 , 20 -diohprog synthesis. In salmonids, the ratio of plasma levels and pituitary contents of GTHs and the secretory control by a GnRH suggest that GTH I is the predominant GTH during vitellogenesis and early stages of spermatogenesis, whereas GTH II is predominant at the time of spermiation and ovulation. GTH I and GTH II are found in distinctly separate cells. In trout, GTH I … More is expressed first in ontogeny, whereas GTH II cells appear coincident with the onset of spermatogenesis and vitellogenesis, and increase dramatically at the time of final reproductive maturation.
Mechanism of GTH actions: Two steroid hormones, estradiol-17 and 17 , 20 -diOHprog are involved in the regulation of vitellogenesis and ovulation, respectively. During vitellogenesis, GTH stimulates the thecal cells to produce testosterone, which are converted to estradiol-17 in granulosa cells by enhancing aromatase enzyme activity. A distinct steroidogenic shift occurs in follicles just prior to oocyte maturation. GTH stimulate thecal cells to produce 17 -OHprog, which is converted to 17 ,20 -diOHprog in granulosa cells by enhancing 20 -OHsteroid dehydrogenase activity. Two steroid hormones are involved in the regulation of two important processes of male germ cell development: 11-ketotestosterone for spermatogenesis and 17 ,20 -diOHprog for spermiation. Analysis of steroid biosynthetic pathways of the testis showed a shift in testicular steroid metabolic enzyme activity in response to GTH. During spermatogenesis, the testis synthesized 11-ketotestosterone, 17 ,20 -diOHprog production results from a change in the pathway, immediately prior to spermiation. GTH stimulates the production of these steroid hormones in ovary and testis via an adenylate cyclase-cAMP-dependent step.
Thyroid hormones: A bioassay of salmon TSH was established based on the increase in plasma thyroxine levels in juvenile rainbow throut. Thyroid hormones are found in the yolk of unfertilized eggs of all teleost studied. Treatment of juvenile salmonids with thyroid hormones caused an increase in oxygen consumption and body silvering, but no consistent effect was seen in seawater adaptability. The tissue and plasma levels of the hormones of chum salmon fry increased just before downstream migration. A marked increase in the tissue levels of the hormones was also observed during metamorphic climax of the flounder larvae, and injection of thyroxine or ovine TSH into pelagic larvae of the flounder accelerated the metamorphosis to benthic larvae. Less

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (115 results)

All Other

All Publications (115 results)

  • [Publications] Young,G.;Adachi,S.;Nagahama,Y.: Dev.Biol.118. 1-8 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagahama,Y.;Goetz,F.W.;Tan,J.D.: Develop,Growth and Differ.28. 555-561 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tan,J.D.;Adachi,S.;Nagahama,Y.: Gen.Comp.Endocrinol.63. 110-116 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 川内浩司・鈴木邦昌: 実験医学. 5. 764-766 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kawauchi,H.: Gunma Symposium onEndocrinology. 24. 183-196 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sakai,N.;Iwamatsu,T.;Yamauchi,K.;Nagahama,Y.: Gen.Comp.Endocrinol.66. 333-342 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagahama,Y.: Develop.Growth and Differ.29. 1-12 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagahama.Y.: Zool.Sci.4. 209-222 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kanamori,A.;Kagawa,H.;Nagahama,Y.: Gen.Comp.Endocrinol.66. 210-217 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tagawa,M.;Hirano,T.: Gen.Comp.Endocrinol.68. 129-135 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Iwata,M.;Komatsu,S.;Hasagawa,S.;Ogasawara,;Hirano,T.: Nippon Suisan Gakkaishi. 53. 1969-1973 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Miwa,S.;Tagawa,T.;Inui,Y;Hitano,T.: Gen.Comp.Endocrinol.70. 158-163 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Suzuki,K.;Kawauchi,H.;Nagahama,Y.: Gen.Comp.Endocrinol.71. 292-301 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Suzuki,K.;Kawauchi,H.;Nagahama,Y.: Gen.Comp.Endocrinol.71. 302-306 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itoh,H;Suzuki,K.;Kawauchi,H.: Gen.Comp.Endocrinol.71. 438-451 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Suzuki,K.;Nagahama,Y.;Kawauchi,H.: Gen.Comp.Endocrinol.71. 452-458 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Suzuki,K.;Kanamori,A.;Nagahama,Y.;Kawauchi,H.: Gen.Comp.Endocrinol.71. 459-467 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kanamori,A.;Adachi,S.;Nagahama,Y.: Gen.Comp.Endocrinol.72. 13-24 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kanamori,A.;Nagahama,Y.: Gen.Comp.Endocrinol.72. 25n-38 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kanamori,A.;Nagahama,Y.: Gen.Comp.Endocrinol.721. 39-53 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kawauchi,H.;Suzuki,K.;Itoh,H;Swanson,P.;Naito,N.;Nagahama,Y.;Nozaki,M.;Nakai,Y.;Itoh,S;: Fish Physiol.Biochem.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nozaki,M.;Naito,N.;Swanson,P.;Miyata,K.;Nakai,Y.;Oota,Y.;Suzuki,K.;Kawauchi,H.: Gen.Comp.Endocrinol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nozaki,M.;Naito,N.;Swanson,P.;Dickhoff.W.;Nakai,Y.;Suzuki,K.;Kawauchi,H.: Gen.Comp.Endocrinol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Swanson,P.;Suzuki,K.;Kawauchi,H.: Gen.Comp.Endocrinol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sakai,N.;Ueda,H.;Suzuki,N.;Nagahama,Y.: Gen.Comp.Endocrinol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itoh,H;Suzuki,K.;Kawauchi,H.: Gen.Comp.Endocrinol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Iwata,M.;Yamamoto,T.;: Effects of thyroid hormone on phototaxis of chum salmon and coho salmon juveniles.Aquacuiture.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tagawa,M.;Hirano,T.: Gen.Comp.Endocrinol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Inui,Y.;Tagawa,M.;Miwa,S.;Hirano,T.: Gen.Comp.Endocrinol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kawauchi,H.;Suzuki,K.;Nagahama,Y.;Adachi,S.;Naito,N.;Nakai,Y.: "Occurrence of two dlstinct gonadotropins in chum salmon pituitary.In "Pars Distalis of the Pituitary Gland--Structure,Function and Regulation"" F.Yoshimura and A.Gorbman,Eds.,Excerpta Medica., 383-390 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagahama,Y.: "Endocrine control of oocyte maturation.In"Hormones and Reproduction in Fishes,Amphibians,and Reptiles"" D.O.Norris and R.E.Jones,eds.,Plenum Press,New York, 171-202 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kawauchi,H.;Suzuki,K.;Itoh,H;Swanson,P.: "Dual gonadotropin system in fish.In"Progress in en-docrinology 1988"" H.Imura,K.Shizume,and S.Yoshida eds.Elsevier Science Publishers B.V.,Amsterdam, 227-232 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagahama, Y.: "17 ,20 -Dihydroxy-4-pregnen-3-one: A teleost maturation- inducing hormone." Development Growth and Differentiation. 29. 1-12 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagahama, Y.: "Gonadotropin action on gametogenesis and steroidogenesis in teleost gonads." Zoological Science. 4. 209-222 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kanamori, A,;Kagawa, H,;Nagahama, Y.: "Gonadotropin receptors in the postovulatory ovary of amago salmon (Oncorhynchus rhodurus)." General and Comparative Endocrinology. 66. 210-217 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tagawa, M,;Hirano, T.: "Presence of tyroxine in eggs and changes in its content during early development of chum salmon, Oncorhynchus keta." General and Comparative Endocrinology. 68. 129-135 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Suzuki, K,;Nagahama, Y,;Kawauchi, H.: "Steroidogenic activities of two distinct salmon gonadotropins." General and Comparative Endocrinology. 71. 452-458 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Iwata, M,;Komatsu, S,;Hasegawa, S,;Ogasawara, T,;Hirano, T.: "Inconsistent effect of thyroid hormone alteration on seawater adaptability of fry of the chum salmon, Oncorhynchus keta." Nippon Suisan Gakkaishi. 53. 1969-1973 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Miwa, S,;Tagawa, T,;Inui, Y,;Hitano, T.: "Thyroxyne surge in metamorphosing flounder larvae." General and Comparative Endocrinology. 70. 158-163 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Suzuki, K,;Kawauchi, H,;NAgahama, Y.: "Isolation and characterization of two distinct gonadotropins from chum salmon pituitary glands." General and Comparative Endocrinology. 71. 292-301 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Suzuki, K,;Kawauchi, H,;Nagahama, Y.: "Isolation and characterization of subunits of two distinct salmon gonadotropins." General and Comparative Endocrinology. 71. 302-306 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itoh, H,;Suzuki, K,;Kawauchi, H.: "The complete amino acid sequence of subunits of two distinct chum salmon gonadotropins." General and Comparative Endocrinology. 71. 438-451 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Young,G,;Adachi,S,;Nagahama,Y.: "Role of ovarian thecal and granulosa layers in gonadotropin-induced synthesis of a salmonid maturation-induced synthesis of a salmonid maturation-inducing substance (17 ,20 -dihydroxy-4-pregnen-3-one)." Developmental Biology. 118. 1-8 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagahama, Y,;Goetz, F.W,;Tan, J.D.: "Shift in steroidogenesis in the ovarian follicles of the goldfish (Carassius auratus) during gonadotropin-induced oocyte maturation." Development Growth and Differentiation. 28. 551-561 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tan, J.D,;Adachi, S,;Nagahama, Y.: "The in vitro effects of cyclic nucleotides, cyanoketone, and cycloheximide on the production of estradiol-17 by vitellogenic ovarian follicles of goldfish (Carassius auratus)." General and Comparative Endocrinology. 63. 110-116 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sakai, N,;Iwamatsu, T,;Yamauchi, K,;Nagahama, Y.: "Development of the steroidogenic capacity of medaka (Oryzias latipes) ovarian follicles during vitellogenesis and oocyte maturation." General and Comparative Endocrinology. 66. 333-342 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nozaki, M,;Naito, N,;Swanson, P,;Miyata, K,;Nakai, Y,;Oota, Y,;Suzuki, K,;Kawauchi, H.: "Salmonid pituitary gonadotroph cells I. Distinct cellular distributions of two gonadotropins, GTH I and GTH II." General and Comparative Endocrinology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nozaki, M,;Naito, N,;Swanson, P,;Dickhoff, W.W,;Nakai, Y,;Suzuki, K,;Kawauchi, H.: "Salmonid pituitary gonadotroph cells II. Ontogeny of GTH I and GTH II cells in the rainbow trout (Salmo gairdneri irideus)." General and Comparative Endocrinology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Swanson, P,;Suzuki, K,;Kawauchi, H.: "Effects of des-Gly^<10>[D-Ala^6]Gonadotropin-Releasing hormone ethlamide GnRHa) on secretion of two distinct gonadotropins by rainbow trout pituitaries In vitro." General and Comparative Endocrinology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sakai, N,;Ueda, H,;Suzuki, N,;Nagahama, Y.: "Steroid production by amago salmon (Oncorhynchus rhodurus) testes at different development stages." General and Comparative Endocrinology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Iwata, M,;Yamamoto, T,;Tagawa, M,;Ida, H,;Hirano, T.: "Effects of thyroid hormone on phototaxis of chum salmon and coho salmon juveniles." Aquaculture.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Suzuki, K,;Kanamori, A,;Nagahama, Y,;Kawauchi, H.: "Development of salmon GTH I and GTH II radioimmunoassays." General and Comparative Endocrinology. 71. 459-467 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kanamori, A,;Adachi, S,;Nagahama, Y.: "Developmental changes in steroidogenic responses of ovarian follicles of amago salmon (Oncorhynchus rhodurus) to chum salmon gonadotropin during oogenesis." General and Comparative Endocrinology. 72. 13-24 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kanamori, A,;Nagahama, Y.: "Developmental changes in the properties of gonadotropin receptors in the ovarian follicles of amago salmon (Oncorhynchus rhodurus) during oogenesis." General and Comparative Endocrinology. 72. 25-38 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kanamori, A,;Nagahama, Y.: "Involvement of 3',5'-cyclic adenosine monophosphate in the control of follicular steroidogenesis of amago salmon (Oncorhynchus rhodurus)." General and Comparative Endocrinology. 72. 39-53 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kawauchi, H,;Suzuki, K,;Itoh, H,;Swanson, P,;Naito, N,;Nagahama, Y,;Nozaki, M,;Nakai, Y,;Itoh, S.: "The duality of teleost gonadotropins." Fish Physiology and Biochemistry.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tagawa, M,;Hirano, T.: "Changes in tissue and blood concentrations of tyroid hormone in developing chum salmon." General and Comparative Endocrinology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Inui, Y,;Tagawa, M,;Miwa, S,;Hirano, T.: "Effects of bovine TSH injection in prometamorphic flounder larvae on the tissue thyroxine level and metamorphosis." General and Comparative Endocrinology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itoh, H,;Suzuki, K,;Kawauchi, H.: "The complete amino acid sequences of two distinct -subunits of salmon gonadotropins." General and Comparative Endocrinology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Naito, N,;Nozaki, M,;Suzuki, K,;Nagahama, Y,;Kawauchi, H.: "Two distinct gonadotrophs in the salmon pituitary: Subcellular localization of GTH I and GTH II immunoreacivity." General and Comparative Endocrinology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagahama, Y.: Endocrine control of oocyte maturation. Hormones and Reproduction in Fishes, Amphibians, and Repriles. Plenum Press, 171-172 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kawauchi, H,;Suzuki, K,;Itoh, H,;Swanson. P.: Dual gonadotropin system in fish. In"Progress in ecdocrinology 1988". Elsevier Science Publishers B.V., 227-232 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kawauchi, H,;Suzuki, K,;Nagahama, Y,;Adachi, S,;Naito, N,;Nakai, Y.: Occurrence of two distinct gonadotropins in chum salmon pituitary. Pars Distalis of the Pituitary Gland-Structure, Function and Regulation. Excerpta Medica., 383-390 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kawauchi, H.: Structure fish pituitary hormone: Evolutionary aspects.Gunma Symposium on Ecdocrinology, 183-196 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Miwa,S.;Tagawa,T.;Inui,Y.;Hitano,T.: Gen.Comp.Endocrinol. 70. 158-163 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Suzuki,K.;Kawauchi,H.;Nawahama,Y.: Gen.Comp.Endocrinol.71. 292-301 (1988)

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  • [Publications] Suzuki,K.;Kawauchi,H.;Nagahama,Y.: Gen.Comp.Endocrinol.71. 302-306 (1988)

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  • [Publications] Itoh,H.;Suzuki,K.;Kawauchi,H.: Gen.Comp.Endocrinol.71. 438-451 (1988)

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  • [Publications] Suzuki,K.;Nagahama,Y.;Kawauchi,H.: Gen.Comp.Endocrinol.71. 452-458 (1988)

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  • [Publications] Suzuki,K.;Kanamori,A.;Nagahama,Y.;Kawauchi,H.: Gen.Comp.Endocrinol.71. 459-467 (1988)

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  • [Publications] Suzuki,K.;Kanamori,A,;Nagahama,Y.;Kawauchi,H.: Gen.Comp.Endocrinol.71. 459-467 (1988)

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  • [Publications] Kanamori,A.;Adachi,S.;Nagahama,Y.: Gen.Comp.Endocrinol.72. 13-24 (1988)

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  • [Publications] Kanamori,A.;Nagahama,Y.: Gen.Comp.Endocrinol.72. 25-38 (1988)

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  • [Publications] Kanamori,A.;Nagahama,Y.: Gen.Comp.Endocrinol.72. 39-53 (1988)

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  • [Publications] Kawauchi,H.;Suzuki,K.;Itoh,H.;Swanson,P.;Naito,N.;Nagahama,Y.;Nozaki,M.;Nakai,Y.;Itoh,S.: Fish Physiol.Biochem.

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  • [Publications] Nazaki,M.;Naito,N.;Swanson,P.;Miyata,K.;Nakai,Y.;Oota,Y.;Suzuki,K.;Kawauchi,H.: Gen.Copm.Endocrinol.

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  • [Publications] Swanson,P.;Suzuki,K.;Kawauchi,H.: Gen.Comp.Endocrinol.

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  • [Publications] Sakai,N.;Ueda,H.;Suzuki,N.;Nagahama,Y.: Gen.Comp.Endocrinol.

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  • [Publications] Itoh,H.,Suzuki,K.,Kawauchi,H.: Gen.Comp.Endocrinol.

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  • [Publications] Iwata,M.;Yamamto,T.;Tagawa,M.;Ida,H.;Hirano,T.: Aquaculture.

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  • [Publications] Tagawa,M.;Hirano,T.: Gen.Comp.Endocrinol.

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  • [Publications] Inui,Y.;Tagawa,M.;Miwa,S.;Hirano,T.: Gen.Copm.Endocrinol.

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  • [Publications] Kawauchi,H.;Suzuki,K.;Itoh,H.;Swanson,P.: "Dual gonadotropin system in fish.In "Progress in endocrinology 1988"" Elsevier Science Publishers B.V., 227-232 (1988)

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  • [Publications] Kanamori,A.;Kagawa,H.;Nagahama,Y.: Gen.Comp.Endocrinol.66. 210-217 (1987)

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  • [Publications] Sakai,N.;Iwamatsu,T.;Yamauchi,K.;Nagahama,Y.: Gen.Comp.Endocrinol.66. 333-342 (1987)

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  • [Publications] Togawa,T.;Hirano,T.: Gen.Comp.Endocrinol.68. 129-135 (1987)

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  • [Publications] Iwata,M.;Komatsu,S.;Hasegawa,S.;Orasawara,T.;Hirano,T.: Bull Jap.Soc.Sci.Fish.53. 1969-1973 (1987)

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  • [Publications] Nagahama,Y.: Develop.Growth Differ.29. 1-12 (1987)

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  • [Publications] Swanson,P.;Suzuki,K.;Kawauchi,H.: submitted to Gen.Comp.Endocrinol.

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  • [Publications] Ito,H.;Suzuki,K.;Kawauchi,H.: submitted to Gen.Comp.Endocrinol.

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  • [Publications] Kanamori,A.;Adachi,S.;Nagahama,Y.: submitted to Gen.Comp.Endocrinol.

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  • [Publications] Kanamori,A.;Nagahama,Y.: submitted to Gen.Comp.Endocrinol.

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  • [Publications] Kanamori,A.;Nagahama,Y.: submitted to Gen.Comp.Endocrinol.

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  • [Publications] Naito,N.;Suzuki,K.;Nakai,Y.;Kawauchi,H.: in preparation.

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  • [Publications] 川内浩司;鈴木邦昌: 実験医学. 5. 88-90 (1985)

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  • [Publications] Suzuki,K.;Kawauchi,H.;Nagahama,Y.: Gen.Comp.Endocrinol.

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  • [Publications] Suzuki,K.;Kawauchi,H.;Nagahama,Y.: Gen.Comp.Endocrinol.

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  • [Publications] Miwa,S.;Tagawa,M.;Inui,Y.;Hirano,T.: Gen.Comp.Endocrinol.

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  • [Publications] Suzuki,K.;Nagahama,Y.;Kawauchi,H.: submitted to Gen.Comp.Endocrinol.

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  • [Publications] Suzuki,K.;Kanamori,A.;Nagahama,Y.;Kawauchi,H.: submitted to Gen.Comp.Endocrinol.

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  • [Publications] Nagahama,Y.: "Endocrine control of oocyte maturation.In"Hormones and reproduction in fishes,amphibians,and reptiles."" D.O.Norris and R.E.Jones,eds.Plenum Press,New York, 613 (1987)

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  • [Publications] Kraak,G.V.D.;Peter,R.E.;Kawauchi,H.;Suzuki,K.: "Immunological characteristics of two glycoproteins from the carp pituitary. In"Proceedings of the third international symposium on reproductive physiology of fish."" Marine Sciences Research Laboratory Memorial University of Newfoundland, 178 (1987)

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  • [Publications] Swanson,P.;Suzuki,K.;Kawauchi,H.: "Effects of des-Gly^<10>〔D-Ala^6〕gonadotropin-releasing hormone ethlamide(GnRH)on secretion of two distinct gonadotropins by salmonid pituitaries in vitro. In"Proc.of the 1st congress of the Asia Oceania Soc. for Comparative Endocrinol.(AOSCE)" E.Ohnishi,Y.Nagahama,H.Ishizaki,eds.Nagoya University Corporation,Printing Section,Nagoya., 368 (1987)

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  • [Publications] Suzuki,K.;Kawauchi,H.;Nagahama,Y.: "Biological characterization of two distinct gonadotropins from chum salmon pituitaries. In"Proceedings of the first congress of the Asia Oceania society for comparative endocrinology(AOSCE)" E.Ohnishi,Y.Nagahama,H.Ishizaki,eds.Nagoya University Corporation,Printing Section,Nagoya., 368 (1987)

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  • [Publications] Kawauchi,H.;Suzuki,K.;Ito,H.;Swanson,P.;Nagahama,Y.: "Duality of salmon pituitary gonadotropins. In"Proceedings of the first congress of the Asia and Oceania society for comparative endocrinolgy(AOSCE)" E.Ohnishi,Y.Nagahama,H.Ishizaki,eds.Nagoya University Corporation,Printing Section,Nagoya., 368 (1987)

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  • [Publications] Ito,H.;Suzuki,K.;Kawauchi,H.: "Primary structure of chum salmon gonadotropin β subunits. In"Proceeding of the first congress of the Asia and Oceania society for comparative endocrinolgy(AOSCE)" E.Ohnishi,Y.Nagahama,H.Ishizaki,eds.Nagoya University Corporation,Printing Section,Nagoya., 368 (1987)

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  • [Publications] Naito,N.;Suzuki,K.;Nakai,Y.;Kawauchi,H.: "Two distinct gonadotrops in the salmon pituitary. In"Proceeding of the 8th international congress of endocrinolgy."" 8th International Congress of Endocrinolgy,

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  • [Publications] Young,G.;Adachi,S.;Nagahama,Y.: Dav.Biol.118. 1-8 (1986)

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  • [Publications] Nagahama,Y.;Goetz,F.w.;Tan,J.D.,: Develop.Growth and Differ.28. 555-561 (1986)

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  • [Publications] Kanamori,A.;Kagawa,H.;Nagahama,Y.: Gen.Comp.Endocrinol.

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  • [Publications] Nagahama,Y.: Develop.Growth and Differ.

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  • [Publications] Sakai,N.;Iwamatsu,T.;Yamauchi,K.;Nagahama,Y.: Gen.Comp.Endocrinol.

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  • [Publications] Kawauchi,H.;Suzuki,K.;Nagahama,Y.;Adachi,S.;Naito,N.;Nakai,Y.: "Occurrence of two distinct gonadotropins in chum salmon pituitary.In "Pars distalis of the pituitary glands-structure,function&regulation"" F.Yoshimura,and A.Gorbman,eds.Elsevier Science Publisher,New.York., 549 (1986)

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Published: 1987-03-31   Modified: 2016-04-21  

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