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FEVER AS A SYMPTOM IN DEFENSE RESPONSE TO STRESSES.

Research Project

Project/Area Number 61304033
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionYamanashi Medical College

Principal Investigator

IRIKI Masami  Dept. of Physiology, Yamanashi Medical College, 医学部生理学講座, 教授 (90072967)

Co-Investigator(Kenkyū-buntansha) YOSHINAGA Masaru  Dept. of Pathology, Kumamoto University, Medical School, 医学部病理学, 教授 (90040196)
YAMANOUCHI Kazuya  The Institute of Medical Science, The University of Tokyo, 医科学研究所, 教授 (30072888)
MURAKAMI Naotoshi  Dept. of Physiology, Yamaguchi University, School of Mediciene, 医学部生理学, 教授 (90040518)
NAGASAKA Tetsuo  Dept. of Physiology, School of Medicine, Kanaxawa University, 医学部生理学, 教授 (80023646)
NAKAYAMA Teruo  Dept. of Physiology, Oosak University Medical School, 医学部生理学, 教授 (80022763)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 1988: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1987: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1986: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsfever / fever syndrome / defence responses / temperature regulation / interleukin / prostaglandins / tumor necrosis factor / Interferon / 生体防御機構 / 体温調節異常 / Tumor Necrosis Factor / Tumor Necrosis Factor;Opioids
Research Abstract

Fever is not merely the rise of body temperature and relevant abnormality of the body temperature requlation, but is a symptoms of integrated defense responses to the stress, such as infection. Thus, to clarify the fever mechanisms, fever was revaluated with respect to fever syndrome. I. Differences in the body temperature regulation between fever and hyperthermia. II. Differences in the fever prosess according to pyrogens and animal species or strains; 1. different processes of fever induced by endotoxin/LPS and by viruses, 2. characteristics of the fever of PIKA rabbits and rats. III. The role of inflammation/LPS--IL-1/INF/TNF--PGE system in fever; 1. production of IL-1 in inflammatory tissues, 2. The effect of IL-1/INF/TNF on hypothalamic neurons, 3. the role of PGE. IV. Fever syndrome; 1. the response of the endocrine system, 2. acute phase responses, 3. relevance to innunology, 4. the responses of sympathetic efferents. The research project was started by the studies on the factors that affect fever processes, such as the difference of pyrogens, of animal species or strains, and of expreimental conditions, and simultaneously, on the role of endogenous pyrogens such as IL-1, INF, TNF in fevr and in fever syndrome. Last year we focused attention on fever syndrome, such as the responses of endocrine system, of trace metals and protein metabolisms(acute phase responses), of immune systems, and of autonomic nervous systems. The results are summarized in the monograph titled "Fever and Fever Syndrome".

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Iriki,M.: Jpn J Physiol. 38. 233-250 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hori,T;Shibata,M;Nakashima,T;Yamasaki M;Asami,A;Asami,T;Koga,H: Brain Res Bull. 20. 75-82 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Murakami,N;Watanabe,T.: Brain Res. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shido,O;Nagasaka,T;Watanabe,T.: J appl Phsyiol. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Imaoka,K;Yoshikawa,Y;Kanai,Y;Yamanouchi K.: Arch Virol. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ohkawara,S;Goto,F;Yoshinaga,M: Acta Pathol Jpn. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 入来正躬編 研究班員 著: "発熱と発熱症候群" 文光堂, 200 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Iriki,M.: "Fever and fever syndrome - current problems" Jpn J Physiol. 38. 233-250 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sjido O,;Nagasaka T,;Watanage T.: "Blunted febrile response to intravenous endotoxin in starved rats" J appl Physiol. in press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hori T,;Shibata M,;Nakashima T,;Yamasaki M,;Asami A,;Asami T,;Koga H.: "Effects of interleukin-l and arachidonate on the preoptic and anterior hypothalamic neurons" Brain Res Bull. 20. 75-82 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Murakami N,;Watanage T.: "Activation of ACTH release is mediated by the same molecule as the final mediator, PGE_2, of fevrile response in rats" Brain Res. in press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Imaoka K,;Yoshikawa Y,;Kanai Y,;Yamanoushi K.: "Characterization of antinuclear antibodies induced in rabbits by rinderpest virus infection" Arch Virol. in press. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ed. Iriki M: Fever and fever syndrome. Bunkodo, 200 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Iriki,M.;Hashimoto,M.;Saigusa,T.: Canadian J.Physiol.Pharmacol.65. 1304-1311 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hori,T.;Kiyohara,T.;Nakashima,T.;Shibata,M.;Koga,H.: Canadian J.Physiol.Pharmacal.65. 1290-1298 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shido,O.;Nagasaka,T.;Watanabe,T.: J.appl.Physiol.(1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Morimoto,A.;Murakami,N.;Nakamori,T.;Watanabe,T.: J.Physiol.383. 629-637 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tsukiyama,K.;Sugiyama,M.;Yoshikawa,Y.;Yamanouchi,K.: Virology. 160. 48-54 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Goto,F.;Goto,K.;Ohkawara,S.;Kitamura,M.;Mori,S.;Takahashi,H.;Sengoku,Y.;Yoshinaga,M.: J.Immunol.140. (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Iriki,M.: A Satellite Symposium on "thermal physiology of the International Congress of Physiological Sciences.July 21-25,1986 University of Calgary,Canada. (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Iriki,M.;Hashimoto,M.aigusa,T.: Canadian J.of Physiol.and Pharmcol.(1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Wake,A.;Morgan,H.R.: Springer-Verlog,New York,Berlin,Heidelberg,London,Paris,Tokyo. (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Shido,O.;Nagasaka,T.: Jpn.J.Physiol.36. 543-554 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hori,T.;Shibata,M.;Nakashima,T.;Yamasaki,M.;Asami,A.et al.: IUPS Proceedings. 16. 21 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hori,T.;Shibata,M.: Neurosci.Res.Suppl.3. S20 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Nakashima,T.;Hori,T.;Shibata,M.;Kiy hara;T.,Asami,A.,Asami,T.: 日本生理学雑誌. 48. 402 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 中島敏博,栗山和文,掘哲郎,清原寿一: 第10回神経科学学術集会予稿集. 69 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 中島敏博,栗山和文,掘哲郎,清原寿一: 第37回西日本生理学会予稿集. 26 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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