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The study on the effects of the immune response to the destruction of periodontal tissue

Research Project

Project/Area Number 61304055
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionDepartment of Periodontology,Meikai University School of Dentistry

Principal Investigator

IKEDA Katsumi  Meikai University School of Dentistry, 歯学部, 教授 (50049350)

Co-Investigator(Kenkyū-buntansha) OKADA Hiroshi  Osaka University School of Dentistry, 歯学部, 教授 (40038865)
UTSUMI Nobuo  Meikai University School of Dentistry, 歯学部, 教授 (20049357)
HARA Koji  Niigata University School of Dentistry, 歯学部, 教授 (20018419)
ISHIKI Tetsuo  Niigata University School of Dentistry, 歯学部, 教授 (70018406)
AONO Masao  Kyushu University School of Dentistry, 歯学部, 教授 (70037498)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥16,500,000 (Direct Cost: ¥16,500,000)
Fiscal Year 1988: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1987: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1986: ¥7,500,000 (Direct Cost: ¥7,500,000)
KeywordsBone destruction / Microbial plaque / Immune response / Bone resorption / Neutrophil / Lymphocyte / Monocyte-macrophage / 結合組織破壊
Research Abstract

Local inflammatory processes induced by dental plaque bacteria are believed to play an important role in destruction of tissue during periodontal disease, although the immunological or microbiological mechanisms are not exactly understood. We have been investigated to make clear to evaluate with immunological or microbiological approach for local periodontitum destruction.
In addition, we purpose to make clear the periodontal disease process (occurance-its destruction) by study plan and method to catch immunological mechanism (neutrophilic leukocyte, monocyte, macrophage, and lymphocyte, etc.) in dental plaque, bacteria, and peripheral blood, or in experimental gingivitis and periodontitis of animal gingive and alveolar bone, or bone resorption assay in vitro.
These investigation have given us the results and suggesting data to make clear immunological mechanism for destruction of periodontal tissue.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] K.IKEDA 他: Advances in Dental Research. 2. 368-371 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.IKEDA 他: 歯科基礎医学会雑誌. 30. 848-850 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.OKADA 他: Advances in Dental Research. 2. 364-367 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.YAJIMA: Advances in Dental Research. 2. 228-233 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.YAJIMA: Histochemistry. 90. 245-253 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.TAKIGUCHI 他: Biochemica et Biophysica Acta. 971. 121-126 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.TAKIGUCHI 他: Life Sciences. 43. 889-896 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.TAKIGUCHI 他: International journal of biochemistry. 19. 489-493 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.OKADA 他: "Recent advances in clinical periosontology" J.Ishikawa et al., 355-358 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] yoshiko MARUMOTO.: "Effects of culture supernatants of leukocytes from periodontal patients on monocyte-mediated hydroxyapatite resorption" Advances in Dental Research. 2. 368-371 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hiroshi OKADA.: "The function of gingival lymphocytes on the establishment of human periodontitis" Advances in dental Research. 2. 364-367 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Toshihiko YAJIMA.: "collagen remodeling in wound healing by gingival fibroblasts in vitro" Advances in dental Research. 2. 228-233 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hisashi,TAKIGUCHI.: "Phospholipase A_2 in macrophage plasma membrane releases arachidonic acid from phosphatidylinositol" Biochimica et Biophysica Acta. 971. 121-126 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yasuko SHIBATA.: "Recognition of acidic phospholipase A_2 activity in plasma membranes of resident peritoneal macrophages" Life Sciences. 43. 889-896 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hiroshi OKADA.: Recent advances in clinical periodontology. J.Ishikawa, et al, 355-358 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.IKEDA 他: Advances in Dental Research. 2. 368-371 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.IKEDA 他: 歯科基礎医学会雑誌. 30. 848-850 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.OKADA 他: Advances in Dental Research. 2. 364-367 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.YAJIMA.: Advances in Dental Research. 2. 228-233 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.YAJIMA.: Histochemistry. 90. 245-253 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.TAKIGUCHI 他: Biochenica et Biophysica Acta. 971. 121-126 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.TAKIGUCHI 他: Life.Sciences. 43. 889-896 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.TAKIGUCHI 他: International journal of biochemistry. 19. 489-493 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.OKADA 他: "Recent advances in clinical periodontology" J.Ishikawa,et al., 355-358 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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