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Japanese definition of bronchial asthma and studies of factors to become severe.

Research Project

Project/Area Number 61304073
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionUniversity of Tokyo

Principal Investigator

MIYAMOTO Terumasa  University of Tokyo, School of Medicine, 医学部(病), 教授 (80010239)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Terumi  Showa Medical College, 内科, 教授 (30053771)
MAKINO Soohei  Dokkyo Medical College, アレルギー内科, 教授 (10049140)
KOBAYASHI Setsuo  University of Gunma, School of Medicine, 医学部, 教授 (40008222)
TAKISHIMA Tamotsu  University of Toohoku, School of Medicine, 医学部, 教授 (20004765)
TAMURA Masashi  Iwata Medical College, 内科, 教授 (60095817)
西本 幸男  広島大学, 医学部・内科, 教授 (30033955)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsAsthma / Definition of Asthma / Aggravation factor of Asthma / 難治性喘息 / ステロイド
Research Abstract

Japanese defintion of bronchial asthma has been made being based upon the recent studies and ideas in bronchial asthma. International definition of asthema of Chiba Foundation Guast Symposium in 1958 and American Thoracic Society Diagnostic Standards Committee in 1962 was also referred. Our definition is "Asthma is a disease characterized by an increased responsiveness of the airway to a variety of stimuli and manifested by repeated dyspnea due to widespread narrowing of the airway, which changes in severity over short periods of time either spontaneously or as a result of therapy, and is not due to pulmonary - cardiovascular diseases with similar symptoms" It may take sometime before this definition is widely accepted in Japan.
Asthma become quite severe in some cases. Such cases were characterized by 1)strong hereditary predisposition, 2)onset of asthma is below age of one, 3)onset of asthma is over age 45, 4)strong atopic predisposition, 5)non-atopic infections type, 6)negative skin test, 7)sensitive to aspirin, 8)increased hyperreactivity of airway to various stimuli, 9)complicated with chronic veonchitis, empyema and chronic ainusitis,etc. Serum total IgE, IgE antibody, IgG1 antibodyand IgG4 antibody did not have close relation to the severity of asthma. Importance of virus infection and immune complexes is under the study.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report

Research Products

(8 results)

All Other

All Publications (8 results)

  • [Publications] 宮本昭正 外: 治療. 68. 6-8 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Miyamoto,T.et al.: Chest. 90. 71-73 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Miyamoto,T.: J.Resp.Disease. 8. 41-42 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 田村昌士 外: 心身医学. 26. 72-? (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 高橋昭三 外: 治療. 60. 1271-1275 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 高橋昭三 外: 治療学. 5. 36-40 (1980)

    • Related Report
      1986 Annual Research Report
  • [Publications] 牧野荘平: "喘息クリニック" 新興医学出版社.東京, 230 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 宮本昭正 外: "気管支喘息の病態と定義について" メヂカルビュー社, 250 (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-30   Modified: 2016-04-21  

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