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MOLECULAR ANTHROPOLOGICAL STUDY OF EVOLUTION OF IMMUNOLOGICAL MULTIGENE FAMILY

Research Project

Project/Area Number 61440007
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Anthropology
Research InstitutionGRANT-IN-AD FOR SCIENTIFIC RESEARCH (A)

Principal Investigator

OMOTO Keiichi  THE UNIVERSITY OF TOKYO, FACULTY OF SCIENCE PROFESSOR, 理学部, 教授 (10011503)

Co-Investigator(Kenkyū-buntansha) SAITOU Naruya  THE UNIVERSITY OF TOKYO, FACULTY OF SCIENCE ASSISTANT, 理学部, 助手 (30192587)
TOKUNAGA Katsushi  THE UNIVERSITY OF TOKYO, FACULTY OF SCIENCE ASSISTANT, 理学部, 助手 (40163977)
UEDA Shintaroh  THE UNIVERSITY OF TOKYO, FACULTY OF SCIENCE ASSISTANT, 理学部, 助手 (20143357)
HIRAI Momoki  THE UNIVERSITY OF TOKYO, FACULTY OF SCIENCE ASSOC. PROFESSOR, 理学部, 助教授 (60156635)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥21,100,000 (Direct Cost: ¥21,100,000)
Fiscal Year 1988: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1987: ¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 1986: ¥12,900,000 (Direct Cost: ¥12,900,000)
KeywordsMolecular evolution / Multigene Family / Immunoglobulin gene / Major histocompatibility complex / Phylogenetic tree / 主要組織適合性複合体 / 主要組織適合性複合 / 多重遺伝子 / 霊長類 / 分子系統 / 分子遺伝学 / 分子人類学 / 補体 / 遺伝子地図
Research Abstract

(1) THE CLONED IMMUNOGLOBULIN C-H GENES WERE COMPARED AMONG HUMAN AND VARIOUS ANTHROPOID APES AND MONKEYS. IT WAS FOUND THAT IN ADDITION TO POINT MUTATION MORE DYNAMIC CHANGES SUCH AS GENE DUPLICATION AND DELETION OCCURRED FREQUENTLY DURING THE EVOLUTION OF THESE LINES (UEDA). (2) USING PULSED-FIELD ELECTRO- PHORESIS, MOLECULAR MAPS OF MEGA BASE LEVEL OF VARIOUS MHC HAPLOTYPES WERE MADE. IT WAS SHOWN THAT THE LARGE SCALE GENETIC CONSTITUTION IS SPECIFIC TO EACH HAPLOTYPE, AND THERE WAS DIFFERENCE IN SIZE UP TO 200 KB AMONG THESE HAPLOTYPES (TOKUNAGA). (3) A CLOSE LINKAGE OF GENES OF HUMAN COMPLEMENT C6 AND C7 WAS CONFIRMED. ALSO, GENETIC POLYMORPHISMS OF C6 AND C7 WERE EXAMINED IN 5 EAST ASIAN POPULATIONS (TOKUNAGA AND OMOTO). (4) A METHOD FOR CONSTRUCTING MOLECULAR PHYLOGENETIC TREE WAS DEVELOPED (NEIGHBOR-JOINING METHOD), AND APPLIED TO THE DATA OF HLA GENE FREQUENCY (SAITOU). (5) A SOMATIC CELL GENETICAL STUDY OF MHC GENES OF CYNOMOLGUS MONKEY SHOWED THAT THE GENES ARE LOCATED ON CHROMOSOME NO. 6 WHICH IS SIMILAR IN FORM AND BANDING PATTERN TO HUMAN CHROMOSOME NO. 6. (HIRAI).

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Sakoyama Y.;Hong K-J.;Byun S.M.;Hisajima H.;Ueda S.,et al.: Proc.Natl.Acad.Sci.USA. 84. 1080-1084 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ueda S.;Matsuda F.;Honjo T.: J.Mol.Evol.27. 77-83 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tokunaga K.;Saueracker G.;Kay P.,et al.: J.Exp.Med.168. 933-940 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Park K.S.;Yanagisawa M.;Tokunaga K.;Omoto K.: Jpn.J.Hum Genet.33. 325-331 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Saitou N.: J.Mol.Evol.27. 261-273 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hirai M.;Terao K.;Cho F.;Honjo S.: Am.J.Primatol.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tokunaga K.;Matsuki K.;Juji T.;Honda Y.: "HLA in Narcolepsy" Springer-Verlag, 208 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Saitou N.: "Molecular Evolution:Computer Analysis of Protein and Nucleic Acid Sequences,a volume of Methods in Enzymology." Academic Press, (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] UEDA S.; MATSUDA F.; HONJO T.: "MULTIPLE RECOMBINATIONAL EVENTS IN PRIMATE IMMUNOGLOBULIN EPSILON AND ALPHA GENES SUGGEST CLOSER RELATIONSHIP OF HUMANS TO CHIMPANZEES THAN TO GORILLAS." JOURNAL OF MOLECULAR EVOLUTION. 27. 77-83 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] TOKUNAGA K.; SAUERACKER G.; KAY P.; ET AL.: "EXTENSIVE DELETIONS AND INSERTIONS IN DIFFERENT MHC SUPRATYPES DETECTED BY PULSED FIELD GEL ELECTROPHORESIS." JOURNAL OF EXPERIMENTAL MEDICINE. 168. 933-940 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] PARK K.S.; YANAGISAWA,M.; TOKUNAGA,K.; OMOTO,K.: "GENETIC POLYMORPHISMS OF COMPLEMENT COMPONENTS C6 AND C7 IN KOREAN." THE JAPANESE JOURNAL OF HUMAN GENETICS. 33. 325-331 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] SAITOU,N.: "PROPERTY AND EFFICIENCY OF THE MAXIMUM LIKELIHOOD METHOD FOR MOLECULAR PHYLOGENY." JOURNAL OF MOLECULAR EVOLUTION. 27. 261-273 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] HIRAI,M.; TERAO,K.; CHO,F.; HONJO,S.: "AN XY/XYY MOSAIC CYNOMOLGUS MONKEY (MACACA FASCICULARIS)." AMERICAN JOURNAL OF PRIMATOLOGY.(1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] TOKUNAGA,K.; MATSUKI,K.; JUJI,T.; HONDA,Y.: HLA IN NARCOLEPSY.SPRINGER-VERLAG, HEIDELBERG, 208 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sakayama Y.;Hong K-J.;Byun S.M.;Hisajima H.;Ueda S.;et al.: Proc.Natl.Acad.Sci.USA. 84. 1080-1084 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ueda S.;Matsuda F.;Honjo T.: J.Mol.Evol.27. 77-83 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tokunaga K.;Saueracker G.;Kay P.;et al.: J.Exp.Med.168. 933-940 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Park K.S.;Yanagisawa M.;Tokunaga K.;Omoto K.: Jpn.J.Hum.Genet.33. 325-331 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Saitou N.: J.Mol.Evol.27. 261-273 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hirai M.;Terao K.;Cho F.;Honjo S.: Am.J.Primatol. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tkunaga K.;Matsuki K.;Juji T.;Honda Y.: "HLA in Narcolepsy" Springer-Verlag,Heidelberg, 208 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Saitou N.: "Molecular Evolution:Computer Analysis of Protein and Mucleic Acid Sequences,a volume of Methods in Enzymology.(in press)." Academic Press, New York, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ueda, S. et al.: Journal of Molecular Evolution. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Sakoyama, Y. et al.: Proc.Natl.Acad.Sci. USA. 84. 1080-1084 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 植田信太郎: 科学. 56. 236-239 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] Saitou Naruya; Omoto Keiichi: Nature. 327. 288 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Saitou Naruya; Nei Masatoshi: Molecular Biology and Evolution. 4. 406-425 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Saitou Naruya: Journal of Molecular Evolution. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Ueda, S et al.: "Cold Spring Harbor Symposium on Quantitative Biology , Vol.51." Cold Spring Harbor Laboratory, 4 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] Tokunaga,K.: Am.J.Human Genet.39. 414-419 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Ueda,S.: Cold Spring Harbor Symposium Quant. Biol.51. (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Hirai,M.: Primates. (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Luo,Z.: Jpn. J. Human Genet.31. 259-262 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Zen,Z.: Jpn. J. Human Genet.31. 263-271 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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