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Experimental studies on the pathogenesis and modulation of age-related pathologies in Senescence Acelerated Mouse (SAM).

Research Project

Project/Area Number 61440033
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionKyoto University

Principal Investigator

TAKEDA Toshio  Chest Disease Research Institute PROFESSOR, 胸部疾患研究所, 教授 (00027088)

Co-Investigator(Kenkyū-buntansha) HIGUCHI Keiichi  Chest Disease Research Institute LECTURER, 胸部疾患研究所, 講師 (20173156)
HOSOKAWA Masanori  Chest Disease Research Institute ASSOCIATE PROFESSOR, 胸部疾患研究所, 助教授 (00127135)
SUZUKI Yasuhiro  Chest Disease Research Institute PROFESSOR, 胸部疾患研究所, 教授 (90027110)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥26,200,000 (Direct Cost: ¥26,200,000)
Fiscal Year 1988: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1987: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1986: ¥12,000,000 (Direct Cost: ¥12,000,000)
KeywordsSenescence Accelerated Mouse (SAM) / Accelerated Senescence / Senile Amyloidosis / Cataract / Osteoporosis / Deficits in Learning and Memory / 変形性顎関節症 / 老化制御 / 老化 / 骨粗髪症 / 抗体産生能 / 脳内モノアミン
Research Abstract

1. Sever senescece-prone series of mice(SAM-P/1,-P/2,-P/3,-P/4,-P/6,-P/7,-P/8) and 3 senescence-resistant series of mice(SAM-R/1,-R/2,-R/3) have been maintained by comtimuous sister-brother breeding in our laboratory. A steady and irreversible increase in the grading score was confirmed in both the SAM-R and SAM-P series, but more marked increase in grading score was observed in the latter than in the former.
2. During these 3 years, 2 pathologies, cataract and degenerative arthritis, were newly selected or discovered in SAM-R/3 and SAM-P/3, respectively.
3. Characteristic pathologies closely associated with senescence are senile amyloidosis in SAM-P/1 and SAM-P/2, senile cataract in SAM-P/3 and SAM-R/3, senile osteoporosis in SAM-P/6, deficits in learning and memory in SAM-P/8 and degenerative arthritis in SAM-P/3. Using these strain of mice, a number of studies on the pathogenesis of these pathologies has been conducted.
4. The mechanism of the modulatory effect on the advancement of senescence by dietary restriction was studied. It was revealed that the modulatory effect was most likely due to maintenance of immune capability and also suppresive effect on autoimmune abnormalities.
5. The murine model of accelerated senescence SAM will be a valuable tool to clarify the pathogenesis of age-related disorders and also to reveal the basic mechanism of ageing.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (58 results)

All Other

All Publications (58 results)

  • [Publications] Higuchi,K. et al.: Journal of Biological Chemistry. 261. 12834-12840 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Miyamoto,M. et al.: Physiology and Behavior. 38. 399-406 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Matsushita,M. et al.: American Journal of Pathology. 125. 276-283 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Akiyama,H. et al.: Acta Neuropathologica. 72. 124-129 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yonezu,T. et al.: Laboratory Investigation. 57. 65-70 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hosokawa,T. et al.: Immunology. 62. 425-429 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Naiki,H. et al.: American Journal of Pathology. 130. 579-587 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hosokawa,M. et al.: Experimental Eye Research. 47. 629-640 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yagi,H. et al.: Brain Research. 474. 86-93 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Naiki,H. et al.: Analytical Biochemistry. 177. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yagi,H. et al.: Journal of Neuropathology and Experimental Neurology. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yoshioka,H. ethal.: Clinical and Experimental Immunology. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Higuchi,K;Takeda,T: "Amyloidosis" Martinus Nijhoff Publishers,Kluwer Academic Publishers group,Dordrecht/Boston/Lancaster, 283-291 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 竹田俊男,樋口京一: "アミロイドーシス" 名古屋大学出版会, 21-30 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeda,T. et al.(editors): "Proceedings of the First SAM Kyoto Symposium" Fuji Printing Business Company,Kyoto, 104 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 秋口一郎,竹田俊男: "老人性痴呆症と脳機能改善薬" シーエムシー東京, 188-193 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Higuchi,K.;et al.: "Purification and characterization of a senile amyloid-related antigenic substance(SAS/SAM) from mouse serum." Journal of Biological Chemistry. 261. 12834-12846 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Miyamoto,M.;et al.: "Age-related changes in learning and memory in the senescence-accelerated mouse(SAM)." Physiology and Behavior. 38. 399-406 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Matsushita,M.;et al.: "Age-related changes in bone mass in the Senescence Accelerated Mouse(SAM): SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis." American Journal of Pathology. 125. 276-283 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Akiyama,H.;et al.: "Periodic acid-Schiff(PAS)-positive, granular structures increase in the brain of senescence accelerated mouse(SAM)." Acta Neuropathologica. 72. 124-129 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yonezu,T.;et al.: "A molecular-pathologic approach to murine senile amyloidosis. Serum precursor apo A-II variant(pro-glu) presents only in amyloidosis prone SAM-P/1 and -P/2 mice." Laboratory Investigation. 57. 65-70 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hosokawa,T.;et al.: "Immune responses in newly developed short-lived SAM mice. II. Selectively impaired T helper cell activity in in vitro antibody response." Immunology. 62. 425-429 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Naiki,H.;et al.: "Metabolism of senile amyloid precursor and amyloidogenesis: Age related acceleration of apolipoprotein A-II clearance in Senescence Accelerated Mouse." American Journal of Pathology. 130. 579-587 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hosokawa,M.;et al.: "Cataract in Senescence Accelerated Mouse(SAM) (II). Development of a new strain of mouse with late-appearing cataract." Experimental Eye Research. 47. 629-640 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yagi,H.;et al.: "Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbance in recent memory." Brain Research. 474. 86-93 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Naiki,H.;et al.: "Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, Thioflavin T." Analytical Biochemistry. 177. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yagi,H.;et al.: "Spontaneous spongiform degeneration of the brain stem in SAM-P/8 mice, a newly developed memory-deficient strain." Journal of Neuropathology and Experimental Neurology. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yoshioka,H.;et al.: "Autoimmune abnormalities in a murine model of accelerated senescence." Clinical and Experimental Immunology. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Higuchi,K.;Takeda,T.: Amyloidosis. Martinus Nijhoff Publishers, Kluwer Academic Publishers Group, Dordrecht/Boston/Lancaster, 283-291 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeda,T. et al. (editors): Proceedings of the first SAM Kyoto symposium. Fuji Printing Business Company, Kyoto, 104 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Naiki,H.;et al.: American Journal of Pathology. 130. 579-587 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hosokawa,M.;et al.: Experimental Eye Research. 47. 629-640 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yagi,H.;et al.: Brain research. 474. 86-93 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Naiki,H.;et al.: Analytical Biochemistry. 177. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yagi,H.;et al.: Journal of Neuropathology and Experimental Neurology. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yoshioka,H.;et al.: Clinical and Experimental Immunology. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takeda,T.;et al.: "Proceedings of the First SAM Kyoto Symposium" Fuji Printing Business Company,Kyoto, 104 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 秋口一郎 他: "老人性痴呆症と脳機能改善薬" シーエムシー東京, 188-193 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yonezu,T. et al.: Laboratory Investigation. 57. 65-70 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Hosokawa,T. et al.: Immunology. 62. 419-423 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Hosokawa,T. et al.: Immunology. 62. 425-429 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Naiki,H. et al.: American Journal of Pathology. 130(3). (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 杉山博 他: 臨床神経. 27. 841-845 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 内木宏延 他: 臨床科学. 24. 221-226 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 樋口京一 他: "アミロイドーシス(内科MOOK No.35)" 金原出版株式会社, 9 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Takeda,T. et al. editors: "Proceedings of the First SAM Kyoto Symposium" Fuji Printing Business Company, 104 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Yonezu,Y.et al.: FEBS Letters. 203. 149-152 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Kunisada,T.et al.: Nucleic Acid Res.14. 5729-5740 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Higuchi,K.et al.: Purification and characterization of a senile amyloid-related antigenic substance(apoSAS/SAM)from mouse serum.J.Biol.Chem.261. 12834-12840 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Miyamoto,M.et al.: Phisiology and Behavior. 38. 399-406 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Matsushita,M.et al.: Am.J.Pathology. 125. 276-283 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Higuchi,K.et al.: FEBS Letters. 207. 23-27 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Akiyama,H.et al.: Acta Neuropathol.72. 124-129 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Higuchi,K.et al.eds.Glenner,G.G.et al.: "A new senile amyloid fibril protein and its putative precursor in Senescence Accelerated Mouse.in Amyloidosis" Plenum Publishing Corporation,New York, 857 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Shimizu,K.et al.eds Glenner,G.G.et al.: "Amyloid deposition in the articular structures of senescence accelerated mouse(SAM).in Amyloidosis" Plenum Publishing Corporation,New York, 857 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Higuchi,K.et al.eds Marrink,J.et al.: "Animal models.in Amyloidosis" Martinus Nijhoff Publishers,Kluwer Academic Publishers Group,Dordrecht/Boston/Lancaster, 378 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Higuchi,K.et al.eds Marrink,J.et al.: "Amyloidogenic protein in mice.in Amyloidosis" Martinus Nijhoff Publishers,Kluwer Academic Publishers Group,Dordrecht/Boston/Lancaster, 378 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 竹田俊男 ほか,大橋勝 編: "アミロイドーシス-皮膚と全身-老化とアミロイド" 名古屋大学出版会, 277 (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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