|Budget Amount *help
¥26,200,000 (Direct Cost: ¥26,200,000)
Fiscal Year 1988: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1987: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1986: ¥12,000,000 (Direct Cost: ¥12,000,000)
1. Sever senescece-prone series of mice(SAM-P/1,-P/2,-P/3,-P/4,-P/6,-P/7,-P/8) and 3 senescence-resistant series of mice(SAM-R/1,-R/2,-R/3) have been maintained by comtimuous sister-brother breeding in our laboratory. A steady and irreversible increase in the grading score was confirmed in both the SAM-R and SAM-P series, but more marked increase in grading score was observed in the latter than in the former.
2. During these 3 years, 2 pathologies, cataract and degenerative arthritis, were newly selected or discovered in SAM-R/3 and SAM-P/3, respectively.
3. Characteristic pathologies closely associated with senescence are senile amyloidosis in SAM-P/1 and SAM-P/2, senile cataract in SAM-P/3 and SAM-R/3, senile osteoporosis in SAM-P/6, deficits in learning and memory in SAM-P/8 and degenerative arthritis in SAM-P/3. Using these strain of mice, a number of studies on the pathogenesis of these pathologies has been conducted.
4. The mechanism of the modulatory effect on the advancement of senescence by dietary restriction was studied. It was revealed that the modulatory effect was most likely due to maintenance of immune capability and also suppresive effect on autoimmune abnormalities.
5. The murine model of accelerated senescence SAM will be a valuable tool to clarify the pathogenesis of age-related disorders and also to reveal the basic mechanism of ageing.