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Studies on granulopoiesis using monoclonal antibodies against granulopoietin

Research Project

Project/Area Number 61440054
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionKyushu University

Principal Investigator

NIHO Yoshiyuki  Kyushu University, Fac. Med., Professor, 医学部, 教授 (60091287)

Co-Investigator(Kenkyū-buntansha) KUDO Jiro  Kyushu University, Fac. Med., Research Associate, 医学部, 助手 (90148940)
OKAMURA Takashi  Kyushu University, Fac. Med., Research Associate, 医学部, 助手 (30136436)
SHIBUYA Tsunefumi  Kyushu University, Fac. Med., Research Associate, 医学部, 助手 (70133171)
OKAMURA Seiichi  Kyushu University, Fac. Med., Assistant Professor, 医学部, 講師 (20136435)
HARADA Mine  Kyushu University, Fac. Med., Assistant Professor, 医学部, 講師 (00019621)
大塚 輝久  九州大学, 医学部, 助手 (20185317)
森岡 英次  九州大学, 医学部, 医員
大原 紀彦  九州大学, 医学部, 医員
Project Period (FY) 1986 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥18,100,000 (Direct Cost: ¥18,100,000)
Fiscal Year 1989: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1988: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1986: ¥7,000,000 (Direct Cost: ¥7,000,000)
Keywordsgranulopoietin / granulopoiesis / monoclonal antibody / G-CSF / GM-CSF / mass culture / enzyme-linked immunosorbent assay / CSF receptor / G-CSF / GM-CSF / G-CSF受容体 / GM-CSF遺伝子発現 / モノクローナル抗体 / GーCSF受容体 / GMーCSF遺伝子発現 / GーCSF遺伝子発現 / 大量細胞培養 / CSF遺伝子発現 / GMーOSF / 低分子ポリエチレングリコール / ELISA法 / 陰イオン交換クロマトグラフィー / 逆相クロマトグラフィー
Research Abstract

We have purified granulopoietin (colony-stimulating factor; CSF) from the conditioned medium (CM) of a CSF-producing cell line using anion exchange column chromatography, gel filtration column chromatography and reverse phase high pressure liquid chromatography. The final preparation showed a single band on SDS-polyacrylamide electrophoresis and possessed a specific activity of 10^8U/mg protein.
We then succeeded in establishing murine hybridomas secreting IgG reacting to human granulocyte CSF (G-CSF). Using this monoclonal antibody and the polyclonal antibody against G-CSF raised in rabbits, a very sensitive enzyme-linked immunosorbent assay (ELISA) was established. Similarly, the ELISA for granulocyte-macrophage CSF (GM-CSF) was also established after monoclonal and polyclonal antibodies against GM-CSF were made in our laboratory. The production of G-CSF or GM-CSF from fresh human cells and cell lines were studied using these sensitive assays. Serum levels of CSF were also studied using these ELISA and high serum levels were detected among patients suffering from infections, neutropenia, and some cases of acute myelogenous leukemia. We also studied their roles in vivo, CSFs were administered to mice and monkeys resulting in elavation of neutrophilic counts. CSFs were proven to be active in promoting clonogenic leukemic blast cell growth in vitro.
A significant number of the receptor for G-CSF was demonstrated in mature neutrophils, human cell lines of either myeloid or myelomonocytoid origins, leukemia blast cells from patients with acute myelogenous leukemia by radioreceptor assay. The cloning of EDNA encoding the receptor for G-CSF is now under the way.

Report

(5 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (175 results)

All Other

All Publications (175 results)

  • [Publications] Otsuka,T.,et al.: "Clonal assay of human B-cell colonies from patients with B-cell-related malignancies and systemic lupus erythematosus." Acta Haematologica Japonica. 49(4). 950-959 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Koga,T.,et al.: "Identification and partial purification of a low-molecular-weight growth inhibitor formed by density-inhibited,tumorigenic V79 Chinese hamster cells." Cancer Research. 46. 4431-4437 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Otsuka,T.,et al.: "Colony assay in patients with multiple myelomaーRelationship between colony growth and clonical stageー." Acta Haematologica Japonica. 49(8). 1792-1799 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ishikawa,M.,et al.: "Marked granulocytosis in C57BL/6 mice bearing a transplanted BMT-11 fibrosarcoma." Journal of National cancer Institute. 78(3). 567-571 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano,Y.,et al.: "Effect of human GM-CSF and G-CSF on clonogenic leukemic blast cells." Cancer Research. 47. 5647-5648 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Aoyagi,K.,et al.: "Aplastic anemia associated with type A viral hepatitis:Possible role of T-lymphocytes." Japanese Journal of Medicine. 26(3). 348-352 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hayashi,S.,et al.: "Human bladder carcinoma cell line HTB9,which secretes a factor to stimulate clonogenic leukemic blast growth,expresses the granulocyte-macrophage colony-stimulating factor" Japanese Journal of Cancer Research(GANN). 78. 1244-1228 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Omori,F.,et al: "Culture of colony-stimulating factor(CSF)-producing human bladder carcinoma cell line(HTB9)on artificial capillaries." Biomedical Research. 8(5). 301-305 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shibuya,T.,et al.: "Analysis of leukemic blast growth factor(LBGF) and autocrine secretion of CSF by leukemic blasts." Acta Haematologica Japonica. 50(8). 1578-1585 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohhara,N.,et al.: "Stimulatory Effect of forphenicinol on normal human bone marrow granulocyte-macrophage progenitor cells mediated by T-lymphocytes." Biomedicine & Pharmacotherapy. 41. 425-428 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano,Y.,et al.: "Synergism of leukemic blast growth factors in medium conditioned by human bladder carcinoma cell line 5637." International Journal of Cell Cloning. 5(6). 504-510 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shibuya,T.,et al.: "Treatment of four patients with myelodysplastic syndrome with a small dose of aclacinomycin-A." Leukemia Research. 11. 851-854 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano,Y.,et al.: "Effect of human G-CSF on clonogenic cells in acute myeloblastic leukemia." European Journal of Cancer & Clinical Oncology. 24(8). 1285-1287 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hirota,Y.,et al.: "Haematopoiesis in the aged as studied by in vitro colony assay." European Journal of Haematology. 40. 83-90 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamaga,S.,et al.: "A human lung cancer cell Line(KONT)secretes a colonystimulating factor for mixed hematopoietic colonies." Biomedical Research. 9(2). 87-93 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kudo,J.,et al.: "Human Ia-Associated invariant chain gene." Biochemical and Biophysical Research Communication. 152(1). 184-189 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Koga,T.,et al.: "Characterization of a low-molecular-weight growth inhibitor formed by density-inhibited,tumorigenic V79 Chinese hamster cells." Cancer Research. 48. 3737-3741 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Otsuka,T.,et al.: "Multipotent hemopoietic progenitor cells in patients with systemic lupus erythematosus." Journal of Rheumatology. 15. 1085-1090 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Otsuka,T.,et al.: "Stimulatory effects of forphenicinol on human B-cell colony formation." International Journal of Immunotherapy. 4(1). 35-39 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Taniguchi,S.,et al.: "Demonstration of three distinct immunological disorders on erythropoiesis in a patient with pure red cell aplasia and autoimmune haemolytic anemia associated with thymona." British Journal of Haematology. 68. 473-477 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamura,S.,et al.: "Expression of the granulocyte/macrophage colony-stimulating factor gene in leukemic blast cells from patients with acute non-lymphocytic leukemia." Biomedicine & Pharmacotherapy. 42. 65-68 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Otsuka,T.,et al.: "Stimulatory effects of bestatin on human B-cell colony farmation." International Journal of Immunopharmacology. 10. 587-591 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano,Y.,et al.: "Growth of clonogenic myeloblastic leukemic cells in the presence of human recombinant erythropoietin in addition to various human recombinant hematopoietic growth factors." Blood. 72(5). 1682-1686 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Harada,M.,et al.: "Role of T lymphocytes in the suppression of hematopoiesis:Hematopoietic suppressive factors and their mRNA expression in activated T lymphocytes." Acta Haematologica Japonica. 51(8). 1531-1539 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohhara,N.,et al.: "Granulocyte-macrophage colony formation in vitro using human non-phagocytic bone marrow cells." Research in Experimental Medicine. 188. 404-409 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Omori,F.,et al.: "Measurement of human G-CSF by enzyme-linked immunosorbent assay using monoclonal antibody." Research in Experimental Medicine. 189. 163-171 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamura,S.,et al.: "Expression of the cytokine genes in hematological malignancies." Acta Hematologica Japonica.52. 1423-1432 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamaga,S.,et al.: "Effect of granulocyte-macrophage colony-stimulating factor on chemiluminescence of human neutrophils." International Jounal of Cell Cloning. 7. 50-58 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano,Y.,et al.: "Effect in liquid suspension culture of human native granulocyte colony-stimulating factor on proliferation and dirrerentiation of blast cells from patients with acute non-lymphocytic leukemia." Cancer Journal. 2(8). 263-266 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Omori,F.,et al.: "Measurement of human granulocyte-macrophage colony-stimulating factor(GM-CSF)by enzyme-linked immunosorbent assay." Biotherapy. 1. 161-167 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tanaka,T.,et al.: "Protective effect of recombinant murine granulocyte-macrophage colony-stimulating factor against Pseudomonas aeruginosa infection in leukocytopenic mice." Infection & Immunity. 57. 1792-1799 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano,Y.,et al.: "Develompent of drug resistance in cultured clonogenic leukemic blast cells during clinical course of myeloblastic leukemia." Oncology. 46. 339-342 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Taniguchi,S.,et al.: "Prostaglandin-mediated suppression of in vitro growth of erythoid progenitor cells." Kidney International. 36. 712-718 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Matsuguchi,T.,et al.: "Molecular cloning of the cDNA coding for proline-rich protein(PRP):Identity of PRP as C4b-binding protein." Biochemical and Biophysical Research Communications.165(1). 138-144 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Aso,T.,et al.: "A case of hybrid phenotypic chronic myelomonocytic leukemia transformed from aplastic anemia." Japanese Journal of Medicine. 28(3). 385-390 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tanaka T.,et al.: "Effects of human recombinant interleukin 2 on murine myeloid colony formation(CFU-C)." International Journal of Immunotherapy. 5(2). 57-63 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Dohmen,K.,et al.: "Mitochondrial URF2 gene is highly expressed in human acute myelogenous leukemia." Blood(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamura,S.,et al.: "Ubenimex stimulates production of colony-stimulating factor from human peripheral mononuclear cells in vitro." Acta Oncologica(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gondo,H.,et al.: "Acute leukemia during pregnancy:Association with immunemediated thrombocytopenia in mother and infant." Acta Haematologica(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hara,T.,et al.: "Human αδ cell receptor-positive cell-mediated inhibition of erythropoiesis in vitro in a patient with type I autoimmune polyglandular syndrome and pure red cell aplasia." Blood(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kondo,S.,et al.: "Direct action of human granulocyte colony-stimulating factor on mature human neutrophils:Flow-cytometric analysis." Research Communications in Chemical Pathology and Pharmacology, in press.(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano,y.,et al.: "Drug sensitivity test for acute myeloblastic leukemia by an effecient leukemic blast colony assay using 5637-conditioned medium as a stimulator." Journal of Medicine(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岡村精一,他: "顆粒球・単球系造血の調節因子ーヒトCSFの分析ー" 臨床血液. 27(7). 1204-1211 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 仁保喜之: "顆粒球と単球系の幹細胞" 医学の歩み. 139(5). 300-302 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 仁保喜之: "In vitro コロニ-法による造血能検査." 診断と治療. 75(3). 649-652 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 山家滋,他: "悪性腫瘍とCSF." 医学の歩み. 143. 509-511 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 浅野嘉延,他: "白血病細胞増殖因子 ーヒト白血病細胞の増殖と分化ー." 医学の歩み. 143(6). 512-514 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 仁保喜之: "幹細胞." 日本内科学会雑誌. 76(5). 14-16 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岡村精一,他: "血液細胞の培養ー臨床医学への還元ー." 組織培養研究. 7(1). 32-34 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 仁保喜之: "CSF(グラヌロポエチン)." 日本内科学会雑誌. 77. 42-48 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 牧野茂義,他: "骨髄および抹消血幹細胞の簡便凍結保存法." 医学のあゆみ. 151(1). 65-66 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 仁保喜之: "急性骨髄性白血病とコロニ-刺激因子." 医学のあゆみ. 150(10). 637-640 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 浅野嘉延,他: "白血病と造血因子." 内科. 64(5). 819-824 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Niho,Y.,et al.: "In New Horizon of Tumor Immunotherapy Colony-stimulating factor-in vitro and in vivo effect." Excerpta Medica,Amsterdam,New York,Oxford., 21(pp.501-521) (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 浅野嘉延,他: "ヒト白血病細胞の増殖と分化.白血病細胞の生物医学的特性とその制御." 癌と化学療法社., 7(PP.263-269) (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 仁保喜之: "骨髄細胞の単離と培養.三井洋司,高木良三郎,市原明,関口守正,松村外志張編" 丸善東京, 8(pp.131-138) (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岡村精一,他: "白血病と造血幹細胞Annual Review血液1987" 中外医学社, 12(pp.93-104) (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 仁保喜之: "白血球の分化.日本生化学会編(続)生化学実験講座8「血液(上)」" 東京化学同人,東京, 57(pp.81-137) (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大塚毅,他: "リンフォカインAnual Review血液1988." 中外医学社, 11(pp.95-105) (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Otsuka, T., et al.: "Clonal assay of human B-cell colonies from patients with B-cell-related malignancies and systemic lupus erythematosus." Acta Haematologica Japonica. 49. 950-959 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Koga, T., et al.: "Identification and partial purification of a low-molecular-weight growth inhibitor formed by density-inhibited, tumorigenic V79 Chinese hamster cells." Cancer Research 46, 4431-4437, 1986.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Otsuka, T., et al.: "Colony assay in patients with multiple myeloma; Relationship between colony growth and clinical stage." Acta Haematologica Japonica 49, 1792-1799, 1986.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamura, S., et al.: "Regulatory factors for granulopoiesis and monocytopoiesis: Analyses of human colony- stimulating factors. In Japanese with English abstract." Japanese Journal of Clinical Hematology, 27: 1204-1211, 1986.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ishikawa, M., et al.: "Marked granulocytosis in C57BL/6 mice bearing a transplanted BMT-11 fibrosarcoma." Journal of National Cancer Institute 78, 567-571, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano, Y., et al.: "Effect of human GM-CSF and G-CSF on clonogenic leukemic blast cells." Cancer Research 47, 5647-5648, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Aoyagi, K., et al.: "Aplastic anemia associated with type A viral hepatitis: Possible role of T-lymphocytes." Japanese Journal of Medicine 26, 348-352, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hayashi, S., et al.: "Human bladder carcinoma cell line HTB9, which secretes a factor to stimulate clonogenic leukemic blast growth, expresses the granulocyte-macrophage colony-stimulating factor gene." Japanese Journal of Cancer Research (GANN) 78, 1224-1228, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Omori, F., et al.: "Culture of colony-stimulating factor (CSF)-producing human bladder carcinoma cell line (HTB9) on artificial capillaries." Biomedical Research 8, 301-305, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shibuya, T., et al.: "Analysis of leukemic blast growth factor (LBGF) and autocrine secretion of CSF by leukemic blasts." Acta Haematologica Japonica 50, 1578-1585, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohhara, N., et al.: "Stimulatory effect of forphenicinol on normal human bone marrow granulocyte-macrophage progenitor cells mediated by T-lymphocytes." Biomedicine & Pharmacotherapy 41, 425-428, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano, Y., et al.: "Synergism of leukemic blast growth factors in medium conditioned by human bladder carcinoma cell line 5637." International Journal of Cell Cloning 5, 504-510, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano, Y., et al.: "Effect of human G-CSF on clonogenic cells in acute myeloblastic leukemia." European Journal of Cancer & Clinical Oncology 24, 1285-1287, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shibuya, T., et al.: "Treatment of four patients with myelodysplastic syndrome with a small dose of aclacinomycin-A." Leukemia Research 11, 851-854, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hirota, Y., et al.: "Haematopoiesis in the aged as studied by in vitro colony assay." European Journal of Haematology 40, 83-90, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamaga, S., et al.: "A human lung cancer cell Line (KONT) secretes a colony-stimulating factor for mixed hematopoietic colonies." Biomedical Research, 9, 87-93, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kudo, J., et al.: "Human Ia-Associated invariant chain gene." Biochemical and Biophysical Research Communication 152, 184-189, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Koga, T., et al.: "Characterization of a low-molecular-weight growth inhibitor formed by density-inhibited, tumorigenic V79 Chinese hamster cells." Cancer Research 48, 3737-3741, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Otsuka, T., et al.: "Multipotent hemopoietic progenitor cells in patients with systemic lupus erythematosus." Journal of Rheumatology 15, 1085-1090, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Otsuka, T., et al.: "Stimulatory effects of forphenicinol on human B-cell colony formation." International Journal of Immunotherapy 4, 35-39, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Taniguchi, S., et al.: "Demonstration of three distinct immunological disorders on erythropoiesis in a patient with pure red cell aplasia and autoimmune haemolytic anemia associated with thymoma." British Journal of Haematology 68, 473-477, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamura, S., et al.: "Expression of the granulocyte/macrophage colony-stimulating factor gene in leukemic blast cells from patients with acute non-lymphocytic leukemia." Biomedicine & Pharmacotherapy 42, 65-68, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Otsuka, T., et al.: "Stimulatory effects of bestatin on human B-cell colony formation." International Journal of Immunopharmacology 10, 587-591, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano, Y., et al.: "Growth of clonogenic myeloblastic leukemic cells in the presence of human recombinant erythropoietin in addition to various human recombinant hematopoietic growth factors." Blood 72, 1682-1686, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Harada, M., et al.: "Role of T lymphocytes in the suppression of hematopoiesis: Hematopoietic suppressive factors and their mRNA expression in activated T lymphocytes." Acta Haematologica Japonica 51, 1531-1539, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohhara, N., et al.: "Granulocyte-macrophage colony formation in vitro using human non-phagocytic bone marrow cells." Research in Experimental Medicine 188, 404-409, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Omori, F., et al.: "Measurement of human G-CSF by enzyme-linked immunosorbent assay using monoclonal antibody." Research in Experimental Medicine 189, 163-171, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Niho, Y., et al.: "Colony-stimulating factor - in vitro and in vivo effect." In New Horizon of Tumor Immunotherapy, M. Torisu & T. Yoshida eds. pp 501-521, Excerpta Medica, Amsterdam, New York, Oxford, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamura, S., et al.: "Expression of the cytokine genes in hematological malignancies." Acta Hematologica Japonica. 52, 1423-1432, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamaga, S., et al.: "Effect of granulocyte-macrophage colony-stimulating factor on chemiluminescence of human neutrophils." International Journal of Cell Cloning 7, 50-58, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano, Y., et al.: "Effect in liquid suspension culture of human native granulocyte colony-stimulating factor on proliferation and differentiation of blast cells from patients with acute non-lymphocytic leukemia." Cancer Journal 2, 263-266, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Omori, F., et al.: "Measurement of human granulocyte-macrophage colony-stimulating factor (GM-CSF) by enzyme-linked immunosorbent assay." Biotherapy 1, 161-167, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tanaka, T., et al.: "Protective effect of recombinant murine granulocyte-macrophage colony-stimulating factor against Pseudomonas aeruginosa infection in leukocytopenic mice." Infection & Immunity 57, 1792-1799, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano, Y., et al.: "Development of drug resistance in cultured clonogenic leukemic blast cells during clinical course of myeloblastic leukemia." Oncology 46, 339-342, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Taniguchi, S., et al.: "Prostaglandin-mediated suppression of in vitro growth of erythroid progenitor cells." Kidney International 36, 712-718, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Matsuguchi, T., et al.: "Molecular cloning of the cDNA coding for proline-rich protein (PRP): Identity of PRP as C4b-binding protein." Biochemical and Biophysical Research Communications. 165, 138-144, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Aso, T., et al.: "A case of hybrid phenotypic chronic myelomonocytic leukemia transformed from aplastic anemia." Japanese Journal of Medicine 28, 385-390, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tanaka, T., et al.: "Effects of human recombinant interleukin 2 on murine myeloid colony formation (CFU-C)." International Journal of Immunotherapy 5(2), 57-63, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Dohmen, K., et al.: "Mitochondrial URF2 gene is highly expressed in human acute myelogenous leukemia." Blood.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamura, S., et al.: "Ubenimex stimulates production of colony-stimulating factor from human peripheral mononuclear cells in vitro." Acta Oncologica.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gondo, H., et al: "Acute leukemia during pregnancy: Association with immune-mediated thrombocytopenia in mother and infant." Acta Haematologica.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hara, T., et al.: "Human gamma delta cell receptor-positive cell-mediated inhibition of erythropoiesis in vitro in a patient with type I autoimmune polyglandular syndrome and pure red cell aplasia." Blood.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kondo, S., et al.: "Direct action of human granulocyte colony-stimulating factor on mature human neutrophils: Flow-cytometric analysis." Research Communications in Chemical Pathology and Pharmacology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano, Y., et al.: "Drug sensitivity test for acute myeloblastic leukemia by an efficient leukemic blast colony assay using 5637-conditioned medium as a stimulator." Journal of Medicine.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Omori,F.,et al.: "Measurement of human G-CSF by enzyme-linked immunosorbent assay using monoclonal antibody." Research in Experimental Medicine. 189. 163-171 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Okamura,S.,et al.: "Expression of the cytokine genes in hematological malignancies." Acta Hematologica Japonica.52. 1423-1432 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yamaga,S.,et al.: "Effect of granulocyte-macrophage colony-stimulating factor on chemiluminescence of human neutrophils." International Journal of Cell Cloning. 7. 50-58 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Asano,Y.,et al.: "Effect in liquid suspension culture of human native granulocyte colony-stimulating factor on proliferation and differentiation of blast cells from patients with acute non-lymphocytic leukemia." Cancer Journal. 2(8). 263-266 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Omori,F.,et al.: "Measurement of human granulocyte-macrophage colony-stimulating factor(GM-CSF)by enzyme-linked immunosorbent assay." Biotherapy. 1. 161-167 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tanaka,T.,et al.: "Protective effect of recombinant murine granulocyte-macrophage colony-stimulating factor against Pseudomonas aeruginosa infection in leukocytopenic mice." Infection & Immunity. 57. 1792-1799 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Asano,Y.,et al.: "Development of drug resistance in cultured clonogenic leukemic blast cells during clinical course of myeloblastic leukemia." Oncology. 46. 339-342 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Taniguchi,S.,et al.: "Prostaglandin-mediated suppression of in vitro growth of erythroid progenitor cells." Kidney International. 36. 712-718 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Matsuguchi,T.,et al.: "Molecular cloning of the cDNA coding for proline-rich protein(PRP):Identity of PRP as C4b-binding protein." Biochemical and Biophysical Research Communications.165(1). 138-144 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Aso,T.,et al.: "A case of hybrid phenotypic chronic myelomonocytic leukemia transformed from aplastic anemia." Japanese Journal of Medicine. 28(3). 385-390 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tanaka,T.,et al.: "Effects of human recombinant interleukin 2 on murine myeloid colony formation(CFU-C)." International Journal of lmmunotherapy. 5(2). 57-63 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Dohmen,K.,et al.: "Mitochondrial URF2 gene is highly expressed in human acute myelogenous leukemia." Blood.

    • Related Report
      1989 Annual Research Report
  • [Publications] Okamura,S.,et al.: "Ubenimex stimulates production of colony-stimulating factor from human peripheral mononuclear cells in vitro." Acta Oncologica.

    • Related Report
      1989 Annual Research Report
  • [Publications] Gondo,H.,et al.: "Acute leukemia during pregnancy:Association with immunemediated thrombocytopenia in mother and infant." Acta Haematologica.

    • Related Report
      1989 Annual Research Report
  • [Publications] Hara,T.,et al.: "Human gamma delta cell receptor-positive cell-mediated inhibition of erythropoiesis in vitro in a patient with type I autoimmune polyglandular syndrome and pure red cell aplasia." Blood.

    • Related Report
      1989 Annual Research Report
  • [Publications] Kondo,S.,et al.: "Direct action of human granulocyte colony-stimulating factor on mature human neutrophils:Flow-cytometric analysis." Research Communications in Chemical Pathology and Pharmacology,in press.

    • Related Report
      1989 Annual Research Report
  • [Publications] Asano,Y.,et al.: "Drug sensitivity test for acute myeloblastic leukemia by an efficient leukemic blast colony assay using 5637-conditioned medium as a stimulator." Journal of Medicine.

    • Related Report
      1989 Annual Research Report
  • [Publications] 牧野茂義,他.: "骨髄および末梢血幹細胞の簡便凍結保存法." 医学のあゆみ. 151(1). 65-66 (1989)

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      1989 Annual Research Report
  • [Publications] 仁保喜之.: "急性骨髄性白血病とコロニ-刺激因子." 医学のあゆみ. 150(10). 637-640 (1989)

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      1989 Annual Research Report
  • [Publications] 浅野嘉延,他.: "白血病と造血因子." 内科. 64(5). 819-824 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Niho,Y,et al.: "In New Horizon of Tumor Immunotherapy Colony-stimulating factor-in vitro and in vivo effect." Excerpta Medica,Amsterdam,New York,Oxford., 501-521 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Asano,Yoshinobu: Blood. 72(5). 1682-1686 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Okamura,Seiichi: Biomedicine&Pharmacotherapy. 42(1). 65-68 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Taniguchi,Syuichi: British Journal of Haematolgy.68. 473-477 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hirota,Yuiichi: European Journal of Haematology.40(1). 83-90 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Asano,Yoshinobu: European Journal of Cancer and Clinical Oncology.24(8). 1285-1287 (1988)

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      1988 Annual Research Report
  • [Publications] Otsuka,Teruhisa: International Journal of Immunotherapy. 4(1). 35-39 (1988)

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      1988 Annual Research Report
  • [Publications] Yamaga,Shigeru: Biomedical Research. 9(2). 87-93 (1988)

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      1988 Annual Research Report
  • [Publications] Otsuka,Teruhisa: Journal of Rheumatology. 15. 1085-1090 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Nose,Yoshiyuki: Japan Hospital. 7. 21-28 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Otsuka,Teruhisa: International Journal of Immunopharmacology. 10(5). 587-591 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Harada,Mine: Acta Haematogica Japonica. 51. 1531-1539 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ohhara,Norihiko: Research in Experimental Medicine. 188. 404-409 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kudou,Jirou: Biochemical and Biophysical Research Communications. 152(1). 184-189 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kurokawa,Satoshi: Journal of Clinical Laboratory Immunology. 25. 131-137 (1988)

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      1988 Annual Research Report
  • [Publications] Koga,Tatuhiko: Cancer Research. 48. 3737-3741 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yamaga,Shigeru: International Journal of Cell Cloning. 7. 50-58 (1989)

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      1988 Annual Research Report
  • [Publications] Nakano,Syuji 他: Mutation Research. 217. 45-51 (1989)

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      1988 Annual Research Report
  • [Publications] Asano,Yoshinobu: Oncology.

    • Related Report
      1988 Annual Research Report
  • [Publications] Omori,Fusayuki: Research in Experimental Medicine.

    • Related Report
      1988 Annual Research Report
  • [Publications] Tanaka,Takeshi: International Journal of Immunotherapy.

    • Related Report
      1988 Annual Research Report
  • [Publications] Asano Y.;Shibuya T.;Okamura S.; Yamaga S.;Otsuka T.;Niho Y.: Cancer Research.47. 5647-5648 (1987)

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      1987 Annual Research Report
  • [Publications] Omori F.;Okamura S.;Hayashi S.; Yamaga S.;Shibuya T.;Niho Y.: Biomedical Research.8. 301-305 (1987)

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      1987 Annual Research Report
  • [Publications] Hayashi S.;Okamura S.;Asano y.; Ohhara n.;Otsuka T.;Shibuya T.;Niho Y.: Japanese Journal of Cancer Research (Gann).78. 1224-1228 (1987)

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      1987 Annual Research Report
  • [Publications] Hirota Y.;Okamura S.;Kimura N.; Shibuya T.;Niho Y.: European Journal of Haematology.40. 83-90 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Asano Y.;Shibuya T.;Okamura S.; Morioka e.;Taniguchi S.;Niho Y.: Interational Journal of Cell Cloning. 5. 504-510 (1987)

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      1987 Annual Research Report
  • [Publications] Shibuya T.;Okamura S.;Niho Y.: Acta Haematologica Japonica.50. 1578-1585 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Aoyagi K.;Ohhara n.;Okamura S.;Otsuka T.;Shibuya T.;Yamano Y.; Tsuda Y.;Niho Y.: Japanese Journal of Medicine.26. 348-352 (1987)

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      1987 Annual Research Report
  • [Publications] Shibuya T.;Morioka E.;Taniguchi S.; Ohhara N.;Okamura S.;Niho Y.: Leukaemia Research.11. 851-854 (1987)

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      1987 Annual Research Report
  • [Publications] Gondo H.;Kudo J.;White JW.;Barr C.; Selvanayagam P.;Saunders GF.: Journal of Immunology. 139. 3840-3848 (1987)

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      1987 Annual Research Report
  • [Publications] 仁保喜之: 日本内科学会雑誌. 76. 640-642 (1987)

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  • [Publications] 浅野嘉延,仁保喜之: 医学の歩み. 143. 512-514 (1987)

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  • [Publications] 山家滋,岡村精一: 医学の歩み. 143. 509-511 (1987)

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  • [Publications] Yamaga S.;Okamura S.;Hayashi S.; Otsuka T.;Shibuya T.;Niho Y.: Biomedical Research.

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      1987 Annual Research Report
  • [Publications] Ohhara N.;Okamura S.;Otsuka T.; Shibuya T.;Niho Y.: Biomedicine & Pharmacotherapy.

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      1987 Annual Research Report
  • [Publications] Taniguchi S.;Shibuya T.;Morioka E.; Okamura T.;Okamurs S.;Inaba S.; Niho Y.: British Journal of Haematology.

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      1987 Annual Research Report
  • [Publications] Otsuka T.;Okamura S.;Ohhara N.; Shibuya T.;Niho Y.: International Journal of Immunotherapy.

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  • [Publications] Otsuka T.;Okamura S.;Ohhara N.; Shibuya T.;Niho Y.: International Journal of Immunopharmacology.

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  • [Publications] Okamura S.;Hayashi S.;Asano Y.; Shibuya T.;Otsuka T.;Niho Y.: Biomedicine & Pharmacotherapy.

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  • [Publications] 三井洋司,高木良三郎,市原明,関口守正,松村外志張 編 仁保喜之: "骨髄細胞" 丸善(東京), 8(131-138) (1987)

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  • [Publications] 仁保喜之: "顆粒球とマクロファージの産生とその調節 日本生化学会編『続生化学実験講座8 血液(上)』" 東京化学同人(東京), 7(81-87) (1987)

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  • [Publications] 高久史麿,青木延雄,仁保喜之,長尾大 編集 岡村精一,仁保喜之,大塚輝久: "『Annual Review 血液 1987年』 白血病と造血幹細胞" 中外医学社(東京), 12(93-104) (1987)

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  • [Publications] 宮崎保監修 浅野嘉延,渋谷恒文,岡村精一,森岡英次,谷口修一,大塚輝久,大原紀彦,林真,山家滋,大森房之,仁保喜之: "『白血病の生物学的特性とその制御』 ヒト白血病細胞の増殖と分化" 癌と化学療法社(東京), 7(263-269) (1987)

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  • [Publications] 高久史麿,青木延雄,仁保喜之,長尾大 編集 大塚毅,仁保喜之: "『Annual Review 血液 1988年』リンフォカイン" 中外医学社(東京), 13(93-105) (1988)

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  • [Publications] 仁保喜之,浅野嘉延,岡村精一,渋谷恒文: "『白血病幹細胞』 第22回日本医学会総会会誌(1)" 日本医学会, 1(219) (1987)

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  • [Publications] 岡村精一,渋谷恒文,仁保喜之: 臨床血液. 27. 1204-1211 (1986)

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  • [Publications] Koga T;Nakano S;Nakayama M;Kounoue E;Nagafuchi S;Niho Y;Yamada H: Cancer Research. 46. 4431-4437 (1986)

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  • [Publications] Otsuka T;Okamura S;Niho Y: Acta Haematologica Japonica. 49. 1792-1799 (1986)

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  • [Publications] Kikuchi M;Takeshita M;Tashiro K;Mitsui T;Eimoto T;Okamura S: Virchows Archiv(Pathol Anat). 409. 299-311 (1986)

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  • [Publications] Nakayama M;Nakano S;Koga T;Iwakiri R;Niho Y: Cancer Research. (1987)

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      1986 Annual Research Report
  • [Publications] Niho Y;Asano Y;Shibuya T;Okamura S: Japanese Journal of Cancer Research(GANN). (1987)

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  • [Publications] 岡村精一,仁保喜之,大塚輝久,高久史磨,青木延雄,仁保喜之,長尾大 編: "白血病と造血幹細胞「Annual Review 血液¨" 中外医学社, 93-104 (1987)

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Published: 1987-03-31   Modified: 2016-04-21  

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