| Project/Area Number |
61440066
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | Mie University |
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Principal Investigator |
MUNEYUKI Mannosuke School of Medicine , Mie University, Professor, 医学部, 教授 (50077583)
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| Co-Investigator(Kenkyū-buntansha) |
KURIOKA Takaaki Hospital, Mie Univ., Lecturer, 医学部・附属病院, 講師 (20178099)
KONISHI Kunihiko School of Medicine, Mie Univ., Associate Professor, 医学部, 助教授 (10077802)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥21,000,000 (Direct Cost: ¥21,000,000)
Fiscal Year 1987: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1986: ¥18,000,000 (Direct Cost: ¥18,000,000)
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| Keywords | Alternating Lung Ventilation / Ventilation-Perfusion Ratio / Inert Gases / Gaschromatograph-Massspectrometry / Excretion-Curve / ダブルルーメンチューブ / レテンション / エクスクリーション / コンピュータプログラム |
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| Research Abstract |
Ventilation-perfusion relationships assessed by the Wagner's technique were studied during synchronous and alternating lung ventilations. All dogs displayed unaltered V/Q distributions with changing ventilation modes, however, mean Q showed anincreasing tendency towards the high V/Q area during synchronous to alternating ventilation.
The V/Q distributions were analyzed also from excretion curves, i.e., the solution for ventilation was first obtained from the excretion curve for the purpose of analyzing V/Q in each lung separately. The recovered V/Q distribution in low V/Q area was less reproducible and reliable than that from a retention curve.
A study of developing a gaschromatography-massspectrometer system(GC-MS) to obtain the ratio of inert gas partial pressures required by the V/Q theory has been performed. A quadrupole MS combined with GC was tested for measurements of trace amounts of foreign gases in air. We found that the GC-MS was able to respond to ethane, cyclopropane, and halothane different form the conclusions by Mastenbrook(1978). We conclude that a GC-MS does provide the capability to implement the multiple inert gases measurement.
A double-lumen tube(MKP-divider) was hand fabricated to separate each lung from the other more reliably. And a comparative study with other available double-lumen tubes (i.e. Robertshaw tube, Kottmeier tube) has been performed suggesting that the MKP-divider was inserted with little risk of lobar obstruction.
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