| Project/Area Number |
61440069
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
MACHIDA Toyohei Jikei Univ. Sch. of Med. Professor, 医学部泌尿器科学教室, 教授 (50056511)
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| Co-Investigator(Kenkyū-buntansha) |
TADA Shinpei Jikei Univ. Sch. of Med. Assistant Professor, 医学部放射線科学教室, 助教授 (00056722)
TATENO Yukio National Institute of radiological Sciences Head Director, 医学部泌尿器科学教室, 部長 (90163493)
TORII Shinichiro Jikei Univ. Sch. of Med. Assistant, 医学部泌尿器科学教室, 助手 (60164068)
OISHI Yukihiko Jikei Univ. Sch. of Med. Assistant Professor, 医学部泌尿器科学教室, 助教授 (40056784)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1986: ¥6,400,000 (Direct Cost: ¥6,400,000)
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| Keywords | magnetic resonance imaging / Gadolinium-DTPA / functional imaging / renal function / renal disease / computed analysis / 体外衝撃波結石破砕 / 腎疾患 / MRIーレノグラム / 機能画像 / ガドリニウムーDTPA / ESWL / シュミレーション / 3次元表示 / 腎機能画像(RENAL FANCTIONAL IMAGE) / 3次元画像 / 腎臓 |
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| Research Abstract |
The kindney has a complex tissue structure and various functions. Due to diverse diseases, the kidney shows different pathological degenerations and renal component changes. In this study, we diagnosed renal lesions by MRI (Magne-tic Resonance Imaging), formed renal functional images with an MRI contrast medium, and determined chemical pathological characteristics of the kidney by computer analysis.
1. MRI-renogram as renal functional images: In an animal experiment, we made kidneys with renal blood flow disorder and those with urinary flow disorder, obtained the sequential T1 after administration of the MRI contrast medium (Gadolinium-DTPA), and prepared MRI-renogram. We obtained characteristic patterns of various pathological states from this renogram.
2. Computer analysis of MRI-renogram: By mathematical analysis of MRI renogram by a computer, we devised parameters showing the renal blood flow rate, glomerular function, and urinary tubular function. This made it possible to quantitatively determine the pathological state of the kidney.
3. Comparative study on MRI and other tomographic imaging modalities for renal pathological characteristics: For clinical cases of renal damage at the time of extracorporeal shockwave lithotripsy, we comparared the diagnostic character-istics of MRI, X-CT, and renal scintigram. As a result, X-CT proved the best technique in evaluation of total renal images, but MRI was the best in providing functional evaluation images of renal tissues. Quantitative evaluation of renal disorder was also possible by MRI computer analysis.
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