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Experimental and clinical studies of hyperthermia on mucosal pathology of upper airway

Research Project

Project/Area Number 61440073
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKagoshima University

Principal Investigator

OHYAMA Masaru  Faculty of Medicine, Kagoshima University, 医学部, 教授 (70024677)

Co-Investigator(Kenkyū-buntansha) FURUTA Shigeru  Medical Hospital, Kagoshima University, 医学部附属病院, 講師 (80128454)
NOBORI Takuo  Faculty of Medicine, Kagoshima University, 医学部, 助教授 (40094164)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥8,800,000 (Direct Cost: ¥8,800,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1986: ¥5,100,000 (Direct Cost: ¥5,100,000)
KeywordsLaserthermia / Aerosol hyperthermia / Arachidonic acid metabolites / Mucociliary function / Nasal allergy / Polyp / Tumor / 鼻アレルギー / 癌 / Nd:YAGレーザー温熱作用 / NdーYAGレーザー温熱作用 / ファイブロネクチン / 内皮細胞 / 鼻粘膜血行動態 / 気道粘膜 / 粘液繊毛機能 / Nd:YAGレーザーサーミア / 局所循環動態 / ヒト甲状腺癌移植ヌードマウス
Research Abstract

1. Laserthermia for treating mucosal pathology in the upper airway We have developed a ceramic probe to insert into the pathological tissues such as nasal polype, masal allergy and tumors and irradiate the Nd:YAG laser omnidirectionally. This new probe can heat a spherical range of 1.5 cm to 43゜C. The main results obtained were as follows: histological findings, biochemical studies of arachidonic acid metabolotes and of hydrooxyprolins measurement on normal rabbit tongue after laserthermia showed very slight effect and relatively short duration of the concomitant inflammation.
The combination of laserthermia and CDDP chemotherapy was found to give a much better cytocidal effect on the tumor tissue in nude mice inplanted with human thyroid cancer cells. In a clical study on 26 cases with head and neck cancers good results were obtained after combined treatment of laserthermia and radiochemotherapy, as well as excellent effectiveness after laserthermic procedure applied to 96 cases with nasal problems.
2. Local aerosal hyperthermia for treating mucosal pathology in the upper airway: An apparatus of the local aerosol hyperthermia for the nasal cavity was developed and was studied on the effectiveness on nasal mucosal pathology. Fundametal studies revealed that the markedly increased volume for the nasal blood flow during this therapy was found, and no any disturbance of the mucociliary activity in vivo was observed by the hyperthermic loat at 43 ゜C. In clinical study, the marked decrease of sensitivity at nasal mucosa by allergen or LT provocation tests after this therapy was found. Additionally, this therapy showed good effectiveness for inprovement of the clinical symptoms in 57 patients with perennial nasal allergy and in 59 ones with coryza.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 昇卓夫: 日本臨床. 45. 202-207 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 大山勝: 耳鼻臨床. 補3. 1-9 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 大山勝: 病態生理. 7. 414-417 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 大山勝: 耳鼻咽喉科展望. 31.補2. 133-146 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M.Ohyama: Acta otolaryngol.(Stockh). Suppl.458. 133-146 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M.Ohyama: ORL(Tokyo). 31. 886-888 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M.Ohyama: "Proceeding of SPIE-The International Society for optical Engineerring Contact Nd:YAG laser thchnique in edonasal surgery" Society of Photo-optical Instrumentation Engineers, 150-156 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M. Ohyama.: "Contact Nd-YAG laser surgery for head and neck tumor" Pract. Otol. (Kyoto). 3. 1-9 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M. Ohyama.: "Localized hyperthermia on pathological mucosa of upper airway" Byotaiseiri. 7. 414-417 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M. Ohyama.: "A randomized double blind trial of treatment of perennial nasal allergy and coryza by aerosol hyperthermia." ORL (Tokyo). 31. 133-146 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M. Ohyama.: "Laserthermia on head and neck malignancies, expermental and clinical studies" Acta otolaryngol. (Stockh). Suppl. 458. 7-12 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M. Ohyama.: "Laser surgery for nasal and paranasal sinus diseases" ORL (Tokyo). 31. 886-888 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M. Ohyama.: Proceeding of SPIE-The International Society for optical Engineering Contact Nd:YAG laser technique in endonasal surgery. Society of Photo-optical Instrumentation Engineers, 150-156 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 昇卓夫,森山一郎,上野員義,宮崎康博,大山勝: 日本臨床. 45(4)別冊. 202-207 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 森本一郎,昇卓夫,上野員義,廣田常治,宮崎康博,大山勝: 日本レーザー医学会誌. 7(3). 31-32 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大山勝,昇卓夫,島哲也,森山一郎: 日本レーザー医学会誌. 6(4). 21-25 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] 矢野博美,吉田茂,大山勝: 日本鼻科学会会誌. 24(1). 82-83 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大山勝,吉田茂,矢野博美,宮崎康博,坂本邦彦: 病態生理. 7(5). 414-417 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大山勝,宮崎康博,吉田茂,矢野博美 他: 耳展. 31補2. 133-146 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大山 勝 他: 現代医療. 19. 3041-3046 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 昇卓夫 他: 日本臨床. 45. 882-887 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 福田勝則 他: 医学のあゆみ. 144. 221-222 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Daikuzono,N. et al.: Med. Instrumentation. 21. 275-277 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 大山 勝: 病態生理.

    • Related Report
      1987 Annual Research Report
  • [Publications] Edit. by Sin. joffe Ohyama, M. et al.: "Advances in Nd:YAG loser Surgery Applications of the Nd:YAG laser in Otorhinolaryngology" Springer- Verlag, New-York, P156-178 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 大山勝 他: 日本レーザー医学誌. 6. 21-25 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 昇卓夫 他: 日本レーザー医学誌. 6. 71-76 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 大山勝 他: 耳鼻臨床. 補3. 1-9 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 矢野博美 他: Therapeutic Research. 4. 1278-1284 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 宮崎康博 他: 日本ハイパーサーミア誌. (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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