Blood-Ocular Barrier;its mophological and functional characteristics.
| Project/Area Number |
61440074
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Gunma University |
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Principal Investigator |
SHIMIZU Koichi Gunma University School of Medicine, 医学部, 教授 (10009946)
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| Co-Investigator(Kenkyū-buntansha) |
NUMAGA Tetsuro Gunma University School of Medicine, 医学部, 助手 (80175520)
KISHI Shoji Gunma University School of Medicine, 医学部, 助手 (30125843)
YONEYA Shin Gunma University School of Medicine, 医学部, 助手 (40143234)
HORIUCHI Tomomitsu Gunma University School of Medicine, 医学部, 講師 (30008320)
OKANO Tadashi Gunma University School of Medicine, 医学部, 講師 (00008351)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥16,500,000 (Direct Cost: ¥16,500,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥15,000,000 (Direct Cost: ¥15,000,000)
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| Keywords | vitreous fluorophotometry / 網膜色素上皮細胞 / 硝子体蛍光測定法 / 高感度ビデオカメラ / 乳酸 / プロスタグランディン |
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| Research Abstract |
The blood-retinal barrier in the ocular fundus protects the intraocular components from hazards. Once this barrier system is disrupted, serious clinical damages may ensue. There are two types of blood-retinal barrier: outer blood-retinla barrier located in the retinal pigment epithelium and inner blood-retinal barrier located in the wall of retinal vessels.
We evaluated the state of disrupted blood-retinal barrier clinically and experimentally with use of vitreous fluorophotometry. As further experimental works, we conducted histopathological, histochemical and fluorescein angiographic studies.
Histopathological and histochemical studies were well in accord with vitreous fluorophotometric findings in experimental models.
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Report
(4 results)
Research Products
(22 results)
