| Project/Area Number |
61440075
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
HONDA Yoshihito Kyoto Univ.Fac.Med.Professor, 医学部, 教授 (90026930)
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| Co-Investigator(Kenkyū-buntansha) |
OGURA Yuichiro Kyoto Univ.Fac.Med.Institution, 医学部, 助手 (70191963)
YOSHIMURA Nagahisa Kyoto Univ.Fac.Med.Institution, 医学部, 講師 (70211662)
ISHIGOOKA Hitoshi Kyoto Univ.Fac.Med.Institution, 医学部, 講師 (80135590)
NEGI Akira Kyoto Univ.Fac.Med.Institution, 医学部, 講師 (00189359)
UENO Satoki Kyoto Univ.Fac.Med.Institution, 医学部, 講師 (20109010)
山川 良治 京都大学, 医学部, 講師 (40166591)
河野 眞一郎 京都大学, 医学部, 講師 (30201445)
平田 昭 京都大学, 医学部, 助手 (10181158)
松村 美代 京都大学, 医学部, 助手 (30144380)
荻野 誠周 京都大学, 医学部, 講師 (50115812)
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| Project Period (FY) |
1986 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥25,800,000 (Direct Cost: ¥25,800,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1988: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1986: ¥18,100,000 (Direct Cost: ¥18,100,000)
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| Keywords | Proliferative vitreoretinopathy / Retinal pigment epithelium / Retinal glial cell / Hyperthermia therapy / Radiation therapy / Drug delivery system / Intercellular matrix / Basement lamina / 網膜色素上皮 / コラ-ゲン線維 / ラジオフリクエンシイ / 細胞内カルシウムイオン / アストログリア / コラーゲン線維 / グリア細胞 / 細胞骨格 / 細胞遊走 / 網膜剥離 / ミューラー細胞 / アストロ細胞 |
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| Research Abstract |
Proliferative vitreoretinopathy (PVR) which occurs in the process of would healing, impairs recovery of visual function. On the other hand, it can be regarded as a neoplasmic reaction, because abnormal cellular proliferation always preexists the onset of PVR. In this investigation, several trials for preventing and treating PVR were made.
1. Preventing cell-release from the subretinal space was discussed. Avoiding the use of cryopexy and preadministration of steroid hormone were suggested to be effective. 2. Continuation of the retinal basement membrane was found to be important in preventing the development of PVR. 3. A surface detergent was used to prevent cell-attachment to the basement membrane, but was toxic at the effective dose. 4. Attempts to immobilize proliferating cells were not successful. 5. Biodegradable microsheres of polyvinyl alcohol (PVA) were prepared for the slow release of anti-proliferative agents. This system markedly suppressed PVR in rabbits. Hyperthermia of the vitreous space also prevented the appearance and development of PVR in rabbits. 6. Substitution of the vitreous space by a biological inactive material like silicone oil before proliferation was effective in some cases. 7. Inhibition of contraction of proliferated tissue was difficult. 8. Photocoagulation increased the adhesion of the retina to the choroid against traction of the vitreous.
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