Biological activity of bacterial components in the pathogenesis of periodontal disease
Grant-in-Aid for General Scientific Research (A)
|Allocation Type||Single-year Grants |
|Research Institution||Kyushu University |
AONO Masao Kyushu University, Faculty of Dentistry, Professor, 歯学部, 教授 (70037498)
MIYATAKE Sachiko Kyushu University, Faculty of Dentistry, Assistant, 歯学部, 助手 (40190798)
HAMACHI Takafumi Kyushu University, Faculty of Dentistry, Assistant, 歯学部, 助手 (80198811)
HARA Yoshitaka Kyushu University, Faculty of Dentistry Hospital, Lecture, 歯学部附属病院, 講師 (60159100)
MAEDA Katsumasa Kyushu University, Faculty of Dentistry, Associate Professor, 歯学部, 助教授 (00117243)
鎮守 信弘 九州大学, 歯学部, 助手 (90163758)
広藤 卓雄 九州大学, 歯学部, 助手 (10189897)
相田 宜利 九州大学, 歯学部, 助手 (10127954)
|Project Period (FY)
1986 – 1987
Completed (Fiscal Year 1987)
|Budget Amount *help
¥21,800,000 (Direct Cost: ¥21,800,000)
Fiscal Year 1987: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1986: ¥17,000,000 (Direct Cost: ¥17,000,000)
|Keywords||Chronic Inflammatory Periodontal Disease / Bacteroides gingivalis / IgG antibody / T Cell B Cell / Macrophage / マクロファージ / ランゲルハンス細胞 / 血中抗体量 / Cell wall成分 / Outer membrane|
Chronic inflammmatory periodontal disease is initiated by bacterial infection. The role of specific gram-negative bacteria in the etiology and pathogenesis of human periodontal disease has been increasingly appreciated in recent years. Furthermore, the host reoponses to these bacteria has been recently focused on. We obtained the following results by analyzing the biological activity of the periodontopathic bacteria (Bacteroides gingivalis).
(1)Cell wall peptidonglycan components of Bacteroides gingivalis induced a strong inflammatory reaction in the skin of Rats.
(2)A positive IgG antibody to Bacteroides gingivalis was observed in the periodontal diseased patient's serum.
(3)The titer of this IgG antibody was correlate with the severity of hte periodontal diseases.
(4)Serum IgG antibody of Chediak-Higashi Syndrome to Bacteroides gingivalis augmented superoxide anion generation by polymorphonuclear leukocytes.
(5)In the human periodontal diseased gingiva, it was observed that the ratio of B cells, macrophage and Langerhans cell were increased in the severe inflammatory sites.
These results indicated that hte immune reaction to Bacteroides gingivalis was Present in the gingiva of hte periodontal diseased patients.
Report (2 results)
Research Products (4 results)