| Project/Area Number |
61440099
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MATSUSHIMA Yoshiharu Department of Neurosurgery,Tokyo Medical and Dental University, 脳神経外科, 助教授 (20134679)
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| Co-Investigator(Kenkyū-buntansha) |
TONE Osamu Department of Neurosurgery,Tokyo Medical and Dental University, 脳神経外科, 助手 (70188762)
YAMAGUCHI Takekane Department of Neurosurgery,Tokyo Medical and Dental University, 脳神経外科, 助手 (60111605)
KOMATSU Kiyohide Department of Neurosurgery,Tokyo Medical and Dental University, 脳神経外科, 講師 (40014104)
OHNO Kikuo Department of Neurosurgery,Tokyo Medical and Dental University, 脳神経外科, 助手 (50014238)
SUZUKI Ryuta Department of Neurosurgery,Tokyo Medical and Dental University, 脳神経外科, 助手 (50154604)
鬼頭 清裕 東京医科歯科大学, 医学部, 助手 (30177878)
青柳 昌樹 東京医科歯科大学, 医学部, 助手 (60175750)
田畑 均 東京医科歯科大学, 医学部・脳神経外科, 助手 (80138479)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 1988: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1987: ¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1986: ¥8,000,000 (Direct Cost: ¥8,000,000)
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| Keywords | Moyamoya disease / Surgical treatment / EDAS / Angiographical findings / Culture of the vascular smooth muscle cells / Data bases of the paper and the patient / 文献・患者データ・ベース / 手術効果 / モヤモヤ病の手術 / Encephaloーduroーarterioーsynangiosis / (EDAS) / EDASの適応 / EDASの脳血管撮影上効果 / 外国人のモヤモヤ病 / モヤモヤ病のスクリーニング / Xenon-enhanced CT / STAの解剖 / Encephalo-duro-arterio-synangiosis(EDAS) / EDASの効果 / EDASの術中・術後合併症 |
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| Research Abstract |
(1) Data base of the national and international papers on moyamoya disease was prepared. (2) Data base of our 91 moyamoya patients was completed. (3) A new Classification of childhood moyamoya dieseas was proposed. (4) Symptoms and signs of the domestic moyamoya patient were analized and compared with those of patients from abroad. (5) Effect, operative indications and perioperative complications of the EDAS, a new operation which we developed to treat moyamoya disease, were analized. (6) Preoperative and postoperative CBF of the patients who underwent EDAS was analized by means of angiography and Xenon enhanced CT. (7) A simplified method of Xenon enhanced CT for redinal cerebral blood flow measurement was developed making it possible to measure the regional blood flow of small children with less load. (8) Mechanism of indirect anastomosis was experimentally studied. (9) Experimental study on ischemic brain was performed as a part of the serial experiments. (10) Vascular smooth muscle fiber obtained at operation was cultured and it was revealed that the vascular smooth muscle cells of the moyamoya patient have biologically different characteristics from the control in cell doubling time and in the reaction to growth factors deribed from the platelet.
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