Crystal growth study on the formation and suppression of Gallstones by in-situ observation
| Project/Area Number |
61460237
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
結晶学
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
KOMATSU Hiroshi Institute for Materials Research (IMR), Tohoku Univ., Prof., 金属材料研究所, 教授 (00108565)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Noriyoshi College of Medical Science, Tohoku Univ., Prof., 医療技術短期大学部, 教授 (20004806)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1987: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1986: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | cholesterol gallstones / cholesterol monohydrate / human bile / model bile / ケノデオキシコール酸 / 渦巻成長 / 球晶 / コレステロール / 胆石 / バイオクリスタル / 結晶成長 / 胆汁 |
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| Research Abstract |
In order to investigate the formation processes of cholesterol gallstones, in-situ observations on various kind of biles were made by using a polarized light microscope or a phase-contrast microscope. We found growth spirals on cholesterol monohydrate single crystals grown in both human and model biles, which were carefully prepared at pH 7.5 using T-CDCA-Na salt and lecithin. Cholesterol was saturated at 37゜c and the driving force for crystallization (supersaturation) eas given by cooling the biles to 25゜c. Further, we succeeded in taking photomicrographs on the initiation of a spherulite which was formed by aggregation of many fine platy cholesterol crystals.
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Report
(2 results)
Research Products
(11 results)
