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Crystal growth study on the formation and suppression of Gallstones by in-situ observation

Research Project

Project/Area Number 61460237
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 結晶学
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

KOMATSU Hiroshi  Institute for Materials Research (IMR), Tohoku Univ., Prof., 金属材料研究所, 教授 (00108565)

Co-Investigator(Kenkyū-buntansha) SUZUKI Noriyoshi  College of Medical Science, Tohoku Univ., Prof., 医療技術短期大学部, 教授 (20004806)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1987: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1986: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordscholesterol gallstones / cholesterol monohydrate / human bile / model bile / ケノデオキシコール酸 / 渦巻成長 / 球晶 / コレステロール / 胆石 / バイオクリスタル / 結晶成長 / 胆汁
Research Abstract

In order to investigate the formation processes of cholesterol gallstones, in-situ observations on various kind of biles were made by using a polarized light microscope or a phase-contrast microscope. We found growth spirals on cholesterol monohydrate single crystals grown in both human and model biles, which were carefully prepared at pH 7.5 using T-CDCA-Na salt and lecithin. Cholesterol was saturated at 37゜c and the driving force for crystallization (supersaturation) eas given by cooling the biles to 25゜c. Further, we succeeded in taking photomicrographs on the initiation of a spherulite which was formed by aggregation of many fine platy cholesterol crystals.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 小松啓: 日本金属学会会報. 26. 508-510 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 小松啓: 鉱物学雑誌. 18. 163-172 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Komatsu;J. Tanaka;N. Suzuki;T. Sato: J. Crystal Growth. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Komatsu;by I. Sunagawa: "Morphology and Growth unit of Crystals,Coincidence site conjugation of cholesterol monohydrate crystals" Terra Pub-Reidel, (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Komatsu: "Spherulite and Coincidence Site Lattice -speculation on the formation processes of gallstones-" Bull. Japan Institute of Metals (in Japanese). 26. 508-510 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Komatsu: "Formation Processes of Gallstones-with special reference to cholesterol gallstones-" Jour. Mineralogical Soc. Japan (in Japanese). 18. 167-172 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Komatsu: "Coincidence site conjugation of cholesterol monohydrate crystals" Morphology and Growth unit of Crystals, Ed. by I. Sunagawa, Terra-Reidel. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Komatsu et. al.: "Surface microtopography of cholesterol monohydrate crystals grown in the solution and biles" Jour. Crystal Growth. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 田中純一,伊勢秀雄,鈴木範美,佐藤寿雄,小松啓: 日本消化器病学会雑誌. 83. 1816 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 田中純一,伊勢秀雄,鈴木範美,佐藤寿雄,小松啓: 日本消化器病学会雑誌. 84. 542 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 田中純一,豊島隆,新谷史明,伊勢秀雄,鈴木範美,佐藤寿雄,小松啓: 第9回東北胆汁酸研究会(発表会予稿集). 3 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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