| Project/Area Number |
61480108
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Osaka University |
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Principal Investigator |
TSUMOTO Tadaharu Osaka University Medical School Professor, 医学部, 教授 (50028619)
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| Co-Investigator(Kenkyū-buntansha) |
SHIROKAWA Tetsuya Osaka University Medical School Research Assistant, 医学部, 助手 (40187547)
SATO Hiromichi Osaka University Medical School Research Assistant, 医学部, 助手 (50154092)
SOBUE Kenji Osaka University Medical School Professor, 医学部, 教授 (20112047)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1987: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1986: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | Synaptic plasticity / Visual Cortex / Calspectin / Fodrin / Protein 4.1 / Development / Cytoskeletal proteins / 免疫組織化学 / 4.1蛋白質 |
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| Research Abstract |
In this project we attempted to see whether or not an expression of membrene-associated, Ca^<2+>/calmobulin-binding proteins, calspectin and 4.1-like protein, is related to developmental changes in the degree of synaptic plasticity in the rat visual cortex. Immunohistochemical stainings of these proteins demonstrated that their expressions in visual cortical neurons were most marked during 10-34 postnatal days and became very weak thereafter to the adult. Since synaptic plasticity in the visual cortex is known to be at the highest level during 10-34 days and very low in the matured cortex, the present results suggest that these membrane-associated proteins may play a role in synaptic plasticity in the developing visual cortex.
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