| Project/Area Number |
61480148
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
細菌学
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| Research Institution | Research Institute for Microbial Diseases, Osaka University |
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Principal Investigator |
MIWATOMI Toshio Research Institute for microbial Diseases, Osaka University, 微生物病研究所, 教授 (60029759)
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| Co-Investigator(Kenkyū-buntansha) |
ARITA Michiko as above, 微生物病研究所, 助手 (10127178)
YOH Myonsuu as above, 微生物病研究所, 助手 (70093482)
TSUJI Takao as above, 微生物病研究所, 助手 (60171998)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1987: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1986: ¥4,800,000 (Direct Cost: ¥4,800,000)
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| Keywords | Shiga toxiu / Futerotoxin produced by llostridium alihiuile Heusalyiu / V / hollisae / 溶血毒 / 腸炎ビブリオ / 志賀毒素 / 耐熱性溶血毒 / 赤痢菌 / 大腸菌 |
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| Research Abstract |
We purified Shiga foxin produced by Shigalla dysenteriae and enterotoxin produced by clostridium difficile It was found that Shiga toxin first a Herts the neuroglia cells by analyse with electron microscope and hystopathology. More over, we found that NAG vibrio, Vibrio naiaicus, and V holisae produced hemolysins auhgenically similar to TDH (Vp-TDH) produced by V parahaemdy was and parified the us. TDH produced by V hollisae (Vh- TDH was further invebjatrel The amino arid reguence of Vh-TDH was defermiued and compared with that of Vp-TDH We found that 22 amino arid substitutions among 165 amino arid residues occurred in Vh-TDH
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