| Project/Area Number |
61480169
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
公衆衛生学
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| Research Institution | University of Tokyo (1988)
山梨医科大学 (1986-1987) |
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Principal Investigator |
HIGURASHI Makoto Professor, Dept. of MCH, Univ. of Tokyo, 医学部, 教授 (00010223)
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| Co-Investigator(Kenkyū-buntansha) |
ODA Masaaki Instructor, Dept. of MCH, Univ. of Tokyo, 医学部, 助手 (20160872)
IIJIMA Sumio Associate Professor, Dept. of Health Sciences, Yamanashi Medical College, 医学部, 助教授 (70114361)
竹下 達也 山梨医科大学, 医学部, 助手 (20150310)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥4,400,000 (Direct Cost: ¥4,400,000)
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| Keywords | Heredity / Malignancy / Neurofiblomatosis / Tuberous sclerosis / Sister chromatid exchange / Chromosome aberration / 遺伝性疾患の包括医療 / 健康管理 / 包括医療 / 遺伝性高発がん疾患群 / ネコナキ症候群 / マイトマイシン / 放射線 / ファンコニー貧血 |
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| Research Abstract |
In order to investigate the biological effects of environmental factors on genetic diseases associated with the high incidence of cancer, this study was done. Lymphocytes from the patients with neurofibromatosis, tuberous sclerosis (TS), Down syndrome and normal controls were studied for sister chromatid exchanges and the cell cycle kinetics in the Mitomycin-C treated cultures and in gamma-ray irradiated cultures. There was no significant differences in SCE frequencies, cell cycle kinetics between abnormal cases and normal controls. However, chromosome aberrations in TS lymphocytes were significantly higher than those in the normal controls at higher dose (4Gy). The dose-related increases in the SCE frequencies were observed in murine bone-marrow cells treated by vinyl acetate in vivo. No differences were found in the augments of the SCEs between the hepatectomyzed and non-hepatectomyzed groups. No cell cycle delyas were indicated in the treated groups.
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