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BRAIN CHOLECYSTOKININ LEVEL IN HEPATIC ENCEPHALOPATHY

Research Project

Project/Area Number 61480191
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionIwate Medical University

Principal Investigator

SATO Shunichi  Iwate Medical University School of Medicine, Professor, 医学部, 教授 (10048275)

Co-Investigator(Kenkyū-buntansha) KATO Akinobu  Iwate Medical University School of Medicine, Instructor, 医学部, 助手 (50177424)
SUZUKI Kazuyuki  Iwate Medical University School of Medicine, Assistant, 医学部, 講師 (00137499)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1986: ¥2,700,000 (Direct Cost: ¥2,700,000)
KeywordsHepatic encephalopathy / EcK fistula dogs / DMN acute hepatic failure / 脳CCK-SIR / 脳遊離アミノ酸 / 血液・髄液アンモニア / 脳CCK-8IR
Research Abstract

Cholecystokinin-like immunoreactivity(CCK-LI) was measured in the brain of EcK fistula dogs and dogs with dimethylnitrosamine-induced (DMN) acute hepatic failure which were prepared as experimental models of hepatic encephalopathy (HE). The results showed a significant reduction of CCK-LI in all cortical regions of Eck fistula dogs, especially in parietal and occipital cortex in which the levels were approximatily 40% of control values. In dogs with acute hepatic failure, CCK-Li reduction was observed in the temporal and parietal cortex (65% and 47% of control values, respectively). These data were compared with the concentrations of typrosine and phenylalanine, precursors of false neurotransmitters suggested as causing HE. Phenylalanine was significantly increased in all areas of cortex of EcK fistula dogs and in occipital cortex of dogs with acute hepatic failure. Tyrosine was also significantly increased in frontal, parietal and occipital cortex of the EcK fistula dogs, and in temporal and occipital cortex of dogs with acute hepatic failure. However, amounts of reduction of CCK-LI level did not cbrrelate with those of increment of the aromatic amino acids in cortex of these HE models. Hte results imply that reduced levels of the excitatory neuropeptide CCK may be elicited by the mechanism distinct from that inducing increase of false neurotransmitters.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 佐藤俊一, 加藤章信, 三浦義明, 鈴木一幸: 病態生理. 6. 637-639 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 三浦義明, 加藤章信, 盛合理, 井上義博, 柏原紀文, 鈴木一幸, 佐藤俊一, 堀内三郎, 立石カヨ子, 浜岡利之: 肝臓. 28. 1263-1264 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] S. Sato;K. Tateishi;A. Kato;K. Suzuki;Y. Miura;Y. Matsuoka;T. Hamaoka: Hepatology.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 三浦義明, 鈴木一幸, 盛合理, 滝川康裕, 井上義博, 加藤章信, 吉田俊巳, 柏原紀文, 佐藤俊一: 日本消化器学会雑誌. 83. 1843 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 三浦義明, 加藤章信, 盛合理, 植田修, 滝川康裕, 井上義博, 吉田俊巳, 柏原紀文, 鈴木一幸, 佐藤俊一: 肝臓. 28. 659 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] S. Sato;A. Kato;Y. Miura;K. Suzuki;K. Tateishi;T. Hamaoka: Gastroenterology. 92. 1770 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Shunichi Sato, Akinobu Kato, Yoshiaki Miura and Kazuyuki Suzuki: "Brain cholecystokinin in hepatic encephalopathy" Medicina philosophica. 6. 637-639 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Yoshiaki Miura, Akinobu Kato, Osamu Moriai, Yoshihiro Inoue, Toshifumi Kashiwabara, Kazuyuki Suzuki, Shunichi Sato, Saburo Horiuchi, Kayoko Tateishi and Toshiyuki Hamaoka: "Cholecystokinin-8 like immunoreactivity (CCK-8 IR) in the brain of ECK's fistula dogs-Correlation to the ammonia levels of blood and cerebrospinal fluid" Acta Hepatologica Japonica. 28. 1263-1264 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Shunichi Sato, Kayoko Tateishi, Akinobu Kato, Kazuyuki Suzuki, Yoshiaki Miura, Yuji Matsuoka and Toshiyuki Hamaoka: "Marked depression of brain cholecystokinin and vasoactive intestinal polypeptide levels in experimental hepatic encephalopathy"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Shunichi Sato, Akinobu Kato, Yoshiaki Miura, Kazuyuki Suzuki, Kayoko Tateishi and Toshiyuki Hamaoka: "Remarkable depression os cholecystokinin level in the brain of dogs with hepatic encephalopathy (abstract)" Gastoenterology. 92. 1770 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 三浦義明,鈴木一幸,ほか: 日消会誌. 83. 1843 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 三浦義明,加藤章信,ほか: 第21回日本肝臓学会東部会抄録集. 114 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] S.Sato,A.Kato,et al.: American Gastroenterological Association Chicago,May 10-13,1987.

    • Related Report
      1986 Annual Research Report
  • [Publications] 佐藤俊一: 病態生理. 5. (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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