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Development of subunit-vaccine derived from glycoprotein complex with in the envelope of human cytomegalovirus

Research Project

Project/Area Number 61480216
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionOsaka University

Principal Investigator

YABUUCHI Hyakuji  Professor, Department of Pediatrics, Osaka University, 医学部, 教授 (20028335)

Co-Investigator(Kenkyū-buntansha) SHIRAKI Kimiyasu  Department of Virology, Research Institute for Microbial Diseases, Osaka Univers, 微生物病研究所, 助手 (50135745)
YAMANISHI Koichi  Department of Virology, Research Institute for Microbial Diseases, Osaka Univers, 微生物病研究所, 助教授 (10029811)
BABA Koichi  Department of Pediatrics, Osaka University, 医学部, 講師 (10127235)
田中 和子  大阪大学, 医学部附属病院, 医院
奥野 良信  大阪大学, 微生物病研究所, 助手 (30112064)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1988: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥3,800,000 (Direct Cost: ¥3,800,000)
Keywordscytomegalovirus / subunit-vaccine / humoral antibody / cellular immune response / 細胞性免疫 / 中和抗体 / 皮内テスト / 臓器移植術 / 免疫不全状能 / 免疫不全状態
Research Abstract

A group of envelope protins of human cytomegalovirus, gA protein, and protein mixtures, prepared from WI-38 cells infected with Town strain, induced neutralizing antibodies and a cellular immune response in quinea pigs.
The same preparations of envelope proteins of the virus were in sufficient for development of immune response in children without specific antibody.

Report

(4 results)
  • 1989 Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 馬場宏一,三上泰司,山本よしこ,田中和子,井藤尚之,金崎巧,河敬世,藪内百治,川原央好,岡田正,佐治文隆,谷澤修,石橋道男,高原央郎,小角幸人,園田孝夫: "血液製剤、輸血、臓器移植とレトロウイルス感染症" 小児科. 28. 559-569 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 金崎巧,田中和子,馬場宏一,藪内百治,石橋道男: "DNAハイブリダイゼ-ション法によるサイトメガロウィルス感染症迅速診断の試み" 臨床とウイルス. 15. 553-558 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 山本よしこ,河敬世,石原重彦,原純一,勇村啓子,土居悟,馬場宏一,藪内百治: "ALL寛解中にサイトメガロウイルス(CMV)肺炎を併発した1男児例" 小児科診療. 50. 120-124 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 小角幸人,町田昌己,高原央郎,市川靖三,石橋道男,園田孝夫,馬場宏一,藪内百治: "腎移植患者における成人T細胞白血病関連抗原に対する抗体について" 移植. 23. 349-353 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 山西弘一,白木公康,奥野良信,高橋理明,石橋道男,小角幸人,高原央郎,園田孝夫,馬場宏一,田中和子,金崎巧,藪内百治: "ヒトサイトメガロウイルス・サブユニットワクチンの開発研究(1)-腎移植術後のサイトメガロウイルス感染症の実態調査-" 厚生省予防接種研究班報告書「予防接種副反応の軽減化と後遺症患者の社会復帰に関する研究」. 224-245 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田中和子,馬場宏一,藪内百治,小角幸人,石橋道男,園田孝夫,: "臓器移植患者のウイルス感染症-特に腎移植患者におけるサイトメガロウイルス抗原の動能と免疫応答について-" 臨床とウイルス. 17. 61-70 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kokado Y, Takahara S, Ishibashi M, Tanaka K, Baba K, Yabuuchi H, Sonoda T.: "Cytomegalovirus infection after renal transplantation; Effect of prophylactic hyperimmunoglogulin" Clin Transplantation. 3. 223-227 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takumi Kanesaki, Koichi Baba, Kazuko Tanaka, Michio Ishibashi, Hyakuji Yabuuchi: "Characterization of Cytomegalovirus Isolates Recovered During Repeated Infection in Renal Transplant Recipients" Journal of Medical Virology. 28. 140-143 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okuno T, Higashi K, Shiraki K, Yamanishi K, Takahashi M, Kokado Y, Ishibashi M, Takahara S, Sonoda T, Tanaka K, Baba K, Yabuuchi H, Kurata T.: "Human Herpesvirus 6(HHV-6) Infection in Renal Transplantation" Transplantation. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田中和子,馬場宏一,藪内百治,小角幸人,石橋道男,園田孝夫: 臨床とウイルス. 17. 61-70 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 田中和子,馬場宏一,藪内百治,清水克彦,谷澤修: 臨床とウイルス. 16. 479-484 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Baba;K.Shiraki;T.Kanesaki;at al.: J.Clin.Microbiol.25. 2193-2196 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Kanesaki;K.Baba;K.Tanaka;M.Ishibashi;H.Yabuuchi: J.Medical virology.

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Shiraki;K.Yamanishi;M.Takanashi;et al.: Lancet.

    • Related Report
      1988 Annual Research Report
  • [Publications] 馬場宏一,田中和子,藪内百治,白木公康,山西弘一,高橋理明: 臨床とウイルス.

    • Related Report
      1988 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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