• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of la antigen on thyroid epithelial cells in pathogenesis of autoimmune thyroiditis in BB/W rat.

Research Project

Project/Area Number 61480253
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionSAITAMA MEDICAL SCHOOL

Principal Investigator

ISHI Jun  PROFESSOR, THE 4TH DEPARTMENT OF INTERNAL MEDICINE, SAITAMA MEDICAL SCHOOL, 医学部, 教授 (40049763)

Co-Investigator(Kenkyū-buntansha) TANIKAWA Toshinori  RESEARCH FELLOW, THE 4TH DEP. INT. MED., SAITAMA MEDICAL SCHOOL, 医学部, 助手 (90167502)
KATAYAMA Shigehiro  ASSISTANT PROF., THE 4TH DEP. INT. MED., SAITAMA MEDICAL SCHOOL, 医学部, 講師 (90167338)
KAWAZU Shoji  ASSISTANT PROF., THE 4TH DEP. INT. MED., SAITAMA MEDICAL SCHOOL, 医学部, 助教授 (30134547)
HARA Yoshihito  ASSISTANT PROF., THE 4TH DEP. INT. MED., SAITAMA MEDICAL SCHOOL, 医学部, 講師 (00112649)
坂詰 良樹  埼玉医科大学, 医学部, 助手 (40167424)
佐藤 健太郎  埼玉医科大学, 医学部, 助手 (40150619)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsPATHOGENESIS OF AUTOIMMUNE THYROIDITIS / EXPERIMENTAL AUTOIMMUNE THYROIDITIS / BB RAT / IODINE METABOLIS / TSH RECEPTOR ANTIBODY / 甲状腺機能低下症 / BB / Wラット / NK細胞活性 / 抗サイログロブリン抗体 / 酵素免疫測定法 / マイトーゲン / la抗原 / ヘルパーT細胞 / 実験的甲状腺炎 / 自己免疫性甲状腺炎
Research Abstract

We have investigated on the pathogenesis of autoimmune thyroiditis (AIT) in BB/W rat with special interest in Ia antigen on thyroid epithelial cells. AIT began to develop from the age of 10 weeks and the incidence was about 60% at the age of 20 weeks. Focal and peri-vascular infiltration of lymphocytes and destruction of epithelial cells were the main histologic characteristics. The majority of the infiltrating lymphocytes had a helper/inducer phenotype and Ia antigen. However, thyroid epithelial cells did not show any Ia antigen at any age, which suggested that Ia antigen on thyroid cells did not have any pathogenic role in this animal model. Thyroid hormone levels in BB/W rat decreased with age and was more decreased in the rats with AIT than those without AIT. TSH levels were already high at the age of 8 weeks when AIT were not seen, suggesting the presence of an abnormality in thyroid hormone production from the period before AIT developed. Furhtermore, antithyroglobulin and anti -thyroid hormome antibodies were detected in the mojority of BB/W rat and began to appear before AIT developed. Therafore, it was speculated that abnormalities in thyroid gland itself resulted in early break down of immunological tolerance. We, then, sutdied on iodine metabolism in BB/W rat. Thyroidal radio-active iodine uptake and iodine content in thyroglobulin fraction were decreased in BB/W rat comparing to normal Wistar rat. TSH receptor antibodies were positive in one third of 16-weeks-old BB/W rat. However, the titers were low and there was no blocking activity against TSH action. Further studies on the abnormalities in thyroidal iodine metabolism are needed. From these studies, it is concluded that the abnormalities in the organ itself may be a factor for the pathogenesis in the organ specific autoimmune phenomena.

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] M.Yanagisawa;Y.Hara;J.Ishii;et al.: Endocrinol.Japon.33. 851-861 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 原義人,柳沢守文,石井淳 他: ホルモンと臨床. 35. 19-27 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 原義人,柳沢守文,石井淳 他: 糖尿病動物. 1. 67-71 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y.Hara;T.Tanikawa;J.Ishii;et al.: "Studies on the tissue T cell subsets in spontaneous lymphocytic thyroiditis in BB/W rats.In Recent progress in thyroidology.Proceedings of the 3rd Asia and Oceania Thyroid Associa" Cristal House Press, 556 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y.Hara;Y.Kawakami;J.Ishii;et al.: "Anti-thyroid hormone and anti-thyroglobulin antibodies in BB/W rat susceptible to spontaneous autoimmune thyroiditis.In The Thyroid 1988.Proceedings of International Thyroid Sympo" ELSEVIER SCIENCE PUBLISHERS B.V., 696 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M. Yanagisawa; Y. Hara; J. Ishii, et al.: "Spontaneous autoimmune thyroiditis in Bio Breeding / Worcester (BB/W) rat." Endocrinol. Japon.33. 851-861 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y. Hara; M. Yanagisawa; J. Ishii, et al.: "Chronic thyroiditis in BB/W rat." Horumon To Rinshou. 35. 19-27 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S. Miura; Y. Hara; J. Ishii, et al.: "Low iodine uptake in lymhpocytic thiroiditis in BB/W rat." Submitted for publication.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y. Hara; S. Miura; J. Ishii, et al.: "TSH receptor antibodies in lymphocytic thyroiditis in BB/W rat." Submitted for publication.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y. Hara; M. Yanagisawa; J. Ishii, et al.: Insulitis and thyroiditis in BB/W rat. In Diabetic Animal.IYAKU JOURNAL K.K., 67-71 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y. Hara; T. Tanikawa; J. Ishii, et al.: Studies on the tissue T cell subsets in spontaneous lymphocytic thyroiditis in BB/W rats. In Recent progress in thyroidology. Proceedings of the 3rd Asia and Oceania Thyroid Association Meeting.CRISTAL HOUSE PRESS, 239-243 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y. Hara; Y. Kawakami; J. Ishii, et al.: Anti-thyroid hormone and anti-thyroglobulin antibodies in BB/W rat susceptible to spontaneous autoimmune thyroiditis. In The Thyroid 1988. Proceedings of International Thyroid Symposium.ELSEVIER SCIENCE PUBLISHERS B.V., 149-152 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M.Yanagisawa,;Y.Hara,;J.Ishii,;et al.: Endocrinol.Japon.33. 851-861 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] 原義人,石井淳 他: 糖尿病動物. 1. 67-71 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.Hara,;J.Ishii,;et al.: In Recent progress in thyroidology. Proceedings of the 3rd Asia and Oceania Thyroid Association Meeting. 239-243 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.Hara,;Y.Kawakami,;J.Ishii,;et al.: In The Thyroid 1988. Proceedings of International Thyreid Symposium.149-152 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 原義人,柳沢守文,石井淳 他: ホルモンと臨床. 35(秋季増刊号). 19-27 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] S.Miura,;Y.hara,;J.Ishii,;et al.: BB/W rat.

    • Related Report
      1988 Annual Research Report
  • [Publications] 原義人;石井淳他: 日本内分泌学会雑誌. 62. 382 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] 谷川俊則;石井淳他: 日本内分泌学会雑誌. 62. 383 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] 原義人;石井淳他: 日本内分泌学会雑誌. 63. 1079 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 河津捷二,石井淳他: 糖尿病. 29. 286 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] 原義人;石井淳他: ホルモンと臨床秋季増刊号『甲状腺学の進歩'87』石井淳編集(総ページ数312). 35. 19-27 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] J.Ishii;M.Yanagisawa;Y.Hara;etal: Frontiers in Thyroidology(eds.Medeirous-Neto G.& GaitanE)Plenum Publishing Corp.New York. 2. 1329-1334 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] Y.Hara;J.Ishii: "Recent Progress in Thyroidology(PP239-244)" Crystal House Press, 556 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 原義人;石井淳: "糖尿病動物(PP67-71)" 医薬ジャーナル社, 305 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 原義人,石井淳,桜井紳一,川上淑人,谷川俊則,その他: 日本内分泌学会雑誌. 62. 382 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Y.Hara;J.Ishii;Y.Kawakami;K.Sato;M.Yanagisawa;et al.: Abstracts of the Third Asia and Oceania Thyroid Association Meeting. 27 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 原義人,石井淳,鈴木将夫,柳沢守文,谷川俊則,その他: 第1回糖尿病動物研究会. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 原義人,石井淳,柳沢守文,谷川俊則,佐藤健太郎,その他: ホルモンと臨床. (1987)

    • Related Report
      1986 Annual Research Report

URL: 

Published: 1987-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi