| Project/Area Number |
61480283
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tottori University |
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Principal Investigator |
KOGA Shigemasa 1st Department of Surgery, Tottori University School of Medicine, 医学部, 教授 (90093591)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Akihiko 1st Department of Surgery, Tottori University School of Medicine, 医学部附属病院, 助手 (80186311)
IITSUKA Yasuo 1st Department of Surgery, Tottori University School of Medicine, 医学部, 助手 (80127430)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | Intraperitoneal free cancer cells / Peritoneal metastasis / Gastric cancer / 持続温熱腹膜灌流 / 腹膜漿膜細胞傷害因子 |
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| Research Abstract |
A major problem after surgery for gastric cancer that invades the gastric serosa is peritoneal metastasis. Free cancer cells which exfoliate from the serosal surface of the primary lesion presumably embed on the remote peritoneal surface and proliferate, giving rise to peritoneal metastasis. Examination of the relationship between the spatial extent of invasion of the gastric serosa in patients with gastric cancer and their post operative survival rate revealed that not only the presence of serosal invasion but also the spatial extent of the invasion were significant factors that influenced the prognosis of patients with gastric cancer.
As there is a renewed interest in the effectiveness of hyperthermia, we have clinically introduced continuous hyperthermic peritoneal perfusion (CHPP) as a prophylactic treatment for peritoneal recurrence after surgery for gastric cancer. Effects of CHPP on changes in cell kinetics were investigated using experimental animal tumors. Cancer cells were accumulated in the G_2-M phase after hyperthermia, and morphological changes of cells such as vacuolation of cytoplasm, multinucleation were noted. Clinically, the cummulative 5-year survival rate in patients receiving CHPP was higher than that of the controls. Based on above, we suggest that in gastric cancer with serosal invasion, prophylactic treatment for peritoneal metastasis by CHPP promises better outcome.
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