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Correlation between concommitant immunity and postoperative recurrence in primary resected lung cancers

Research Project

Project/Area Number 61480293
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionChiba University School of Medicine

Principal Investigator

FUJISAWA Takehiko  Department of Surgery, Institute of Pulmonary Cancer Resarch, 医学部, 助教授 (80110328)

Co-Investigator(Kenkyū-buntansha) FUKASAWA Toshio  Department of Surgery, Institute of Pulmonary Cancer Resarch, 医学部, 医員
YUSA Toshikazu  Department of Surgery, Institute of Pulmonary Cancer Resarch, 医学部, 助手 (10182669)
SHIBA Mitsutoshi  Department of Surgery, Institute of Pulmonary Cancer Resarch, 医学部, 助手 (20162620)
KIMURA Hideki  Department of Surgery, Institute of Pulmonary Cancer Resarch, 医学部, 講師 (10161572)
YAMAGUCHI Yutaka  Department of Surgery, Institute of Pulmonary Cancer Resarch, 医学部, 教授 (80009448)
斉藤 博明  千葉大学, 医学部, 助手 (40186953)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1986: ¥4,000,000 (Direct Cost: ¥4,000,000)
KeywordsPrimary lung cancer / Surgery / Chemothrapy / Immunotherapy / Cytotoxic activity / tumor concommitant immunity / Biological response modifiers / recurrence / 転移 / 原発生肺癌
Research Abstract

The objective of this study is to demonstrate the correlation between cytotoxic activity against autologous tumor cells and postoperative recurrence in primary resected lung cancers. Autologus tumor cells were cultured by the specimens oftained from primary sites and peripheral blood lymphocytes were separated by Ficoll-Hypaqye discontunuous gradient and utilized as effectors to measure postoperative cytotoxic activity. The rusults obtained herein are as follows:
1) Overall cytotoxic activities against autologous tumor cells ranged from -3.9-39.6% with an average of 16.1%, and the average cytotoxic activities against established lung adenocarcinoma cell line PC-3 and leukemia cell line K562 were 29.6% and 46.5%, respectiyely. No statistically significant changes of cytotoxic activities against these 3 targets to stages or resectabilities were demonstrated, but there existed some differences between histologic types, that is, the cytotoxic activity against autologous tumor cells in adeno … More carcinoma tend to be higher than that of squamous cell carcinoma (P<0.1 by Student t test)
2) When the cytotoxic activity against autologous tumor cells in adenocarcinoma was evaluated by stages, the value of stage I was significantly higher than that of stage IV(P<0.05 by Student t test), however, there were no significant changes between any stages in squamous cell carcinoma. Furthermore, no statistically significant differences between any stages in the cytotoxic activities against PC-3 or K562 targets of adenocarcinoma were demonstrated.
3) In patients given a complete resection, the cytotoxic activity against the autologous tumor cells during the postoperative 1-2 weeks was significantly higher than during the postoperative 4-5 weeks (P<0.05, Student t test). In patients given an incomplete resection, however, no significant difference was demonstrated between the postoperative 1-2 weeks and during the postoperative 4-5 weeks.
4) In contrast, the cytotoxic activity against the PC-3 cells or K562 cells during the postoperative 4-5 weeks tended to rise in comparison to those at the postoperative 1-2 weeks all patients in any cancer stage and whatever the amount of their lung resection.
From these rusults, we conclude that there may exist a concommitant immunity in primary lung cancers, and that ATCA appears to be a good prognostic parameter in lung cancers, particularly adenocarcinomas. Less

Report

(4 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 山口豊、藤沢武彦、木村秀樹: がん治療のあゆみ. 7. 137-144 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 藤沢武彦、深沢敏男、斉藤幸雄、卜部憲和、野本靖史、山川久美、馬場雅行、木村秀樹、山口豊: Oncologia. 21. 99-105 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 藤沢武彦、深沢敏男、斉藤幸雄、卜部憲和、野本靖史、山川久美、馬場雅行、木村秀樹、山口豊: 癌の臨床. 34. 1922-1926 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Fujisawa;Y.Yamaguchi;H.Kimura;M.Shiba;T.Yusa;H.Yamakawa: Cancer. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takehiko Fujisawa;Yutaka Yamaguchi;Hiroaki Saitoh: "Leucocyte dialysate and transfer factor" Institute of Vorology Slovak Academy of Science, (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takehiko Fujisawa;Yutaka Yamaguchi;Hideki Kimura;Mitsutoshi Shiba;Hisami Yamakawa;Sadao Obata: "Proceedings of 6th International Workshop on Transfer Factor" Chinese Transfer Factor Committee, (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yutaka Yamaguchi; Takehiko Fujisawa; Hideki Kimura: "Postoperative multi-modality treatment in primary resected lung cancers, in special referrence to the inhibition of postoperative recurrence by immunochemotherapy" Gan Tiryo no Ayumi. 137-144 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takehiko Fujisawa; Toshio Fukasawa; Yukio Satoh; Norikazu Urabe; Yasushi Nomoto; Hisami Yamakawa; Masayuki Baba; Hideki Kimura; Yutaka Yamaguchi: "Cytotoxic activity in primary resected lung cancer patients" Oncologia. 99-105 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takehiko Fujisawa; Toshio Fukasawa; Yukio Saitoh; Norikazu Urabe; Nomoto Yasushi; Hisami Yamakawa; Masayuki Baba; Hideki Kimura; Yutaka Yamaguchi: "Postoperative sequential testing of cytotoxic activity against the autologous and allogeneic tumor cells in primary lung resected cancer patients" Gan no. Rinsho. 1922-1926 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takehiko Fujisawa; Yutaka Yamaguchi; Hideki Kimura; Mitsutoshi Shiba; Toshikazu Yusa; Hisami Yamakawa: "Correlation between cytotoxic activity against autologous tumor cells and postoperative recurrence in primary resected lung cancers" Cancer. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Leucocyte dialysate; transfer factor Takehiko Fujisawa,Yutaka Yamaguchi,Hiroaki Saitoh: Randomized control study of adjuvant immunotherapy with transfer factor on primary non-small cell carcinoma of the lung-the results of 3 to 8 years follow-up. Institute of Virology Slovak Academy of Science, 436-450 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 山口豊、藤沢武彦、木村秀樹: がん治療のあゆみ. 7. 137-144 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 藤沢武彦、深沢敏男、斉藤幸雄、ト部憲和、野本靖史、山川久美、馬場雅行、木村秀樹、山口豊: Onclogia. 21. 99-105 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 藤沢武彦、深沢敏男、斉藤幸雄、ト部憲和、野本靖史、山川久美、馬場雅行、木村秀樹、山口豊: 癌の臨床. 34. 1922-1926 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Fujisawa.T;Yamaguchi.Y;Kimura.H;Shiba.M;Yusa.T;Yamakawa.H: Concer. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Fujisawa.T;Yamaguchi.Y;Kimura.H;Shiba.M;Yamakawa.H;Obata.S: "Proceedings of the 6th International Workshop on Transfer Factor" Chinese Transfer factor Committee, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 山口豊;藤沢武彦;斉藤博明: MedicalPractice. 3. 2002-2006 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] 馬場雅行;山口豊;藤沢武彦;木村秀樹: 癌と化学療法.

    • Related Report
      1987 Annual Research Report
  • [Publications] 藤沢武彦;深沢敏男;斉藤幸雄;卜部憲和;野本靖史;山川久美;馬場雅行;木村秀樹;山口豊: Oncologia.

    • Related Report
      1987 Annual Research Report
  • [Publications] 藤沢武彦;深沢敏雄;斉藤幸雄;卜部憲和, 野本靖史, 山川久美, 馬場雅行;木村秀樹;山口豊: 癌の臨床.

    • Related Report
      1987 Annual Research Report
  • [Publications] T.Fujisawa;Y.Yamaguchi;H.Saitoh: "Leukocyte dialysates and Transfer Factor" Instituteof Viorogy,Slovak Academy of Science, 612 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 山口豊;藤沢武彦;木村秀樹: "がん集学的治療研究報告書" がん集学的治療研究財団, (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 山口豊,藤沢武彦,斉藤博明: Medical Practice. 3. 2002-2006 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] T.Fujisawa;Y.Yamaguchi;H.Saitoh: "Proceedings of fifth International Workshop on Transfer Factor" Slovok Academy of Science, (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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