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Experimental, Clinical Research of The Ventricular Assist Device in Combined Use with IABP and in Its Weaning Method.

Research Project

Project/Area Number 61480294
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionTOKYO MEDICAL AND DENTAL UNIVERSITY

Principal Investigator

SAKAMOTO Tohru  Tokyo Medical and Dental University, School of Medicine, Department of Thoracic Surgery., 医学部胸部外科, 講師 (10101875)

Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsVentricular Assist Device / Renal Blood Flow / Intraaortic Balloon Pumping / Low Output Syndrome / Bisected Diastolic Driving Method / 左室機能曲線 / 開心術後低心拍出量症候群 / 拡張期2分法(Bisected Diastolic Drive) / 左心機能曲線
Research Abstract

Simultaneous drive of left ventricular assist device (LVAD) and intraaortic balloon pumping (IABP) is needed frequently but infration of intraaortic balloon affects as a resistance against counterpulsed LVAD flow and reduces renal blood flow (BF), resulted in renal dysfunction. To resolve this disadvantage, a new sequential method, Bisected Diastolic Driving (BDD) is devised. After bisecting the aortic diastole, LVAD ejects on early half of the diastole and subsequently intraaortic balloon is inflated on the remained late one, On BDD, two devices act ad counterpulsation (CP) to failing heart (FH) generating high aortic pressure (AP) with non-disturbed distribution of systemic BF, and deflation of balloon produces systolic unloading to FH. Exparimentally, decrease of renal BF and fraction on BDD was smaller then on usual combination which widely used. Two surgical cases with FH revealed impaired renal function under conventional LVAD- IABP drive up to 48 hours, but progressive improvement of renal function was observed 12 hours after BDD use. Case 1 showed s-cr 4.5 - 1.4mg/dl,BUN 60 - 38mg/dl and case 2, s-cr 3.4 - 1.4mg/dl, BUN 57 - 38mg/dl and they weaned fron LVAD within 5 days after surgery maintaining normal renal function. Determination of left ventricular function curve is very easy and accuarte method to dicise the timing of the weaning from LVAD, and inlet-outlet canula with pressure senser was devised to obtain accurate left atrial and aortic pressures from the chamber of LVAD.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 坂本徹: 胸部外科. 39. 213-219 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 坂本徹: 臨床強度外科. 6. 240-242 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 坂本徹: 人工臓器. 16. 3-6 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 坂本徹: 人工臓器. 16. 114-117 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 坂本徹: 臨床胸部外科. 7. 227-229 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tohru Sakamoto: Trans. Amer. Soc. Artif. Intern. Organs.10. 708-713 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tohru,Sakamoto: "Clinical Application of left Ventricular Assist Device." Japanese Journal of Thoracic Surgery. 39. 213-219 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tohru,Sakamoto: "Report of a Case Successfully Weaned from a Left Ventricular Assist Device (LVAD) Following LV Aneurysmectomy, and the Comparative Analysis Between the Case and Other Two Cases who Underwent Cardiac Surgery Under the Prophylactic Stand-by of LVAD." Japanese Annuls of Thoracic Surgery. 6. 240-242 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tohru,Sakamoto: "Clinical Application of Left Ventricular Assist Device in Patients with Profound Heart Failure Following Cardiac Surgery." Japanese Journal of Artificial Organs. 16. 3-6 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tohru,Sakamoto: "Clinical Effecitiveness of Bisected Diastolic Driving to Control Concomitant Use of Left Ventricular Assist Device and IABP." Japanese Journal of Artificial Organs. 16. 114-117 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tohru,Sakamoto: "Clinical Effectiveness of Combined Use of LVAD and IABP as an Bisected Diastolic Driving Method." Japanese Annuls of Thoracic Surgery. 7. 227-229 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tohru,Sakamoto: "Bisected Diastolic Driving to Control Combined Clonical Use of Left Ventricular Assist Device and Intraaortic Balloon Pumping and Its Effect on Renal Function." Transactions of American Society of Artificial Internal Organs. 10. 708-713 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 坂本徹: 人工臓器. 16. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 坂本徹: 人工臓器. 16. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Tohru Sakamoto: Trans.Am.Soc.Artif.Intern.Organs. 33. (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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