| Project/Area Number |
61480315
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
MATSUNO Takeo (1987-1988) Hokkaido University School of Medicine, 医学部, 助教授 (10165847)
佐々木 鉄人 (1986) 北海道大学, 医学部, 助教授 (70001881)
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| Co-Investigator(Kenkyū-buntansha) |
MINAMI Akio Hokkaido University Medical Hospital, 医学部付属病院, 講師 (20133738)
松野 丈夫 北海道大学, 医学部附属病院, 講師 (10165847)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥5,600,000 (Direct Cost: ¥5,600,000)
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| Keywords | Chemoterapy / Osteosarcoma / フローサイトメトリー / ヌードマウス移植骨軟部腫瘍 / 人工的肺転移 / 薬剤感受性テスト / 自然肺転移 |
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| Research Abstract |
Since 1986. we continued to do research on the effect of chemotherapy on osteosarcoma metastasizing to lung in nude mouse. We devided these metastatic osteosarcoma into 4 groups according to the types of chemotherapy. Among these groups, the group of combined chemotherapy with ADR, MTX, Cis-platinum and ifomide proved to be the most effective for the treatment of metastatic osteosarcoma.
We also performed clinical research using this combined chemotherapy on the patients of malignant bone and soft tissue tumor cases. The cases included 6 cases of osteosarcoma, 2 cases of Ewing's sarcoma, one case each of malignant fibrous histiocytoma and angiosarcoma of osseous origin and 2 cases each of malignant fibrous histiocytoma and liposarcoma of soft tissue origin and rhabdomyosarcoma of soft tissue origin. Among these 15 malignant tumors, only two cases showed poor response to the chemotherapy and remaining 13 cases shwed at least partial response.
Out of these clinical results, it was proved that our research of chemotherapy using nude mouse was effective way of predicting the effectiveness of chemotherapy on certain types of malignant bone or soft tissue tumors. And also it was proved that the combined chemotherapy with ADR, MTX, Cis-platinum and lfomide was effective of these malignant tumors.
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